Protein: LDHB
L-lactate dehydrogenase B chain (LDH-B) (EC 1.1.1.27) (LDH heart subunit) (LDH-H) (Renal carcinoma antigen NY-REN-46)

Gene: LDHB
Organism: Homo sapiens
Interactions: 237
UniProt ID: P07195

Gene Ontology (top 5):
GO:0004459 - L-lactate dehydrogenase (NAD+) activity
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

358578

LDHA
L-lactate dehydrogenase A chain

20

14

High-throughput

0.989

High

450903

LDHB
L-lactate dehydrogenase B chain

6

14

Small-scale

0.939

High

450905

LDHC
L-lactate dehydrogenase C chain

4

14

High-throughput

0.896

High

450958

PEX5
Peroxisomal targeting signal 1 receptor

1

3

High-throughput

0.740

High

240504

PRKN
E3 ubiquitin-protein ligase parkin

4

14

High-throughput

0.686

High

451017

HUWE1
E3 ubiquitin-protein ligase HUWE1

3

4

High-throughput

0.640

High

451063

ACE2
Angiotensin-converting enzyme 2

3

2

Small-scale

0.640

High

451071

UN45A
Protein unc-45 homolog A

1

6

High-throughput

0.618

High

450981

CUL3
Cullin-3

2

3

High-throughput

0.611

High

140112

SDCB1
Syntenin-1

2

3

High-throughput

0.606

High

450917

CFTR
Cystic fibrosis transmembrane conductance regulator

2

5

High-throughput

0.601

High

450926

VCAM1
Vascular cell adhesion protein 1

2

2

High-throughput

0.601

High

450965

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

2

1

Small-scale

0.595

High

413022

P53
Cellular tumor antigen p53

2

3

High-throughput

0.584

High

450933

CTNB1
Catenin beta-1

2

0

Small-scale

0.576

High

450961

TERF1
Telomeric repeat-binding factor 1

1

2

High-throughput

0.573

High

450963

TERA
Transitional endoplasmic reticulum ATPase

2

4

High-throughput

0.571

High

451032

DOCK8
Dedicator of cytokinesis protein 8

2

3

High-throughput

0.571

High

287848

MYCB2
E3 ubiquitin-protein ligase MYCBP2

1

1

High-throughput

0.541

High

135455

DNM1L
Dynamin-1-like protein

1

2

High-throughput

0.536

High

361058

SODC
Superoxide dismutase [Cu-Zn]

1

5

High-throughput

0.536

High

388905

FINC
Fibronectin

1

4

High-throughput

0.536

High

450904

CATD
Cathepsin D

1

1

High-throughput

0.536

High

450907

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

5

High-throughput

0.536

High

450911

TAU
Microtubule-associated protein tau

1

5

High-throughput

0.536

High

450920

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

6

High-throughput

0.536

High

450930

PML
Protein PML

1

9

High-throughput

0.536

High

450931

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

4

High-throughput

0.536

High

450938

SOAT1
Sterol O-acyltransferase 1

1

2

High-throughput

0.536

High

450941

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

4

High-throughput

0.536

High

450982

CUL4B
Cullin-4B

1

3

High-throughput

0.536

High

450983

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

6

High-throughput

0.536

High

450985

CKAP5
Cytoskeleton-associated protein 5

1

2

High-throughput

0.536

High

451022

MYLK4
Myosin light chain kinase family member 4

1

7

High-throughput

0.536

High

451033

RIN3
Ras and Rab interactor 3

1

1

High-throughput

0.536

High

451037

PP4R1
Serine/threonine-protein phosphatase 4 regulatory subunit 1

1

1

High-throughput

0.536

High

451041

CSN5
COP9 signalosome complex subunit 5

1

1

High-throughput

0.536

High

451046

REPS1
RalBP1-associated Eps domain-containing protein 1

1

1

High-throughput

0.536

High

451049

COQ2
4-hydroxybenzoate polyprenyltransferase, mitochondrial

1

1

High-throughput

0.536

High

451055

PSB7
Proteasome subunit beta type-7

1

5

High-throughput

0.536

High

451084

ARHGC
Rho guanine nucleotide exchange factor 12

1

1

High-throughput

0.536

High

105133

APRIO
Alternative prion protein

2

3

High-throughput

0.533

High

450996

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

8

High-throughput

0.515

High

450947

HD
Huntingtin

1

6

High-throughput

0.515

High

450923

H2AX
Histone H2AX

1

0

High-throughput

0.513

High

451080

POTE1
Protection of telomeres protein 1

1

1

High-throughput

0.504

High

185357

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

1

High-throughput

0.501

High

451016

HEAT3
HEAT repeat-containing protein 3

1

2

High-throughput

0.489

High

451075

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

1

High-throughput

0.489

High

450910

PTPRF
Receptor-type tyrosine-protein phosphatase F

1

1

Small-scale

0.481

High

451081

UBP40
Ubiquitin carboxyl-terminal hydrolase 40

1

4

Small-scale

0.481

High

125150

LEG9
Galectin-9

1

1

High-throughput

0.479

High

227316

SPOP
Speckle-type POZ protein

1

1

High-throughput

0.479

High

293071

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.479

High

299028

FLOT1
Flotillin-1

1

2

High-throughput

0.479

High

302325

RNF8
E3 ubiquitin-protein ligase RNF8

1

5

High-throughput

0.479

High

315021

RECQ4
ATP-dependent DNA helicase Q4

1

3

High-throughput

0.479

High

319305

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

324419

HEXI1
Protein HEXIM1

1

2

High-throughput

0.479

High

336829

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

2

Small-scale

0.479

High

345267

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

2

High-throughput

0.479

High

349739

SNAI1
Zinc finger protein SNAI1

1

1

High-throughput

0.479

High

375091

RASK
GTPase KRas

1

4

High-throughput

0.479

High

385368

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

5

Small-scale

0.479

High

400130

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

3

Small-scale

0.479

High

411193

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.479

High

425257

ISG15
Ubiquitin-like protein ISG15

1

14

High-throughput

0.479

High

450906

VIME
Vimentin

1

1

High-throughput

0.479

High

450908

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

9

Small-scale

0.479

High

450909

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

9

Small-scale

0.479

High

450912

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

450913

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

3

High-throughput

0.479

High

450914

UBL4A
Ubiquitin-like protein 4A

1

12

High-throughput

0.479

High

450916

XRCC6
X-ray repair cross-complementing protein 6

1

1

High-throughput

0.479

High

450918

ITA4
Integrin alpha-4

1

5

High-throughput

0.479

High

450921

VAV
Proto-oncogene vav

1

3

High-throughput

0.479

High

450925

CEBPB
CCAAT/enhancer-binding protein beta

1

8

High-throughput

0.479

High

450927

RAB4A
Ras-related protein Rab-4A

1

5

High-throughput

0.479

High

450928

CDK2
Cyclin-dependent kinase 2

1

2

High-throughput

0.479

High

450935

PHB1
Prohibitin 1

1

5

High-throughput

0.479

High

450937

MSX2
Homeobox protein MSX-2

1

2

High-throughput

0.479

High

450940

TRI23
E3 ubiquitin-protein ligase TRIM23

1

3

High-throughput

0.479

High

450942

BRCA1
Breast cancer type 1 susceptibility protein

1

9

High-throughput

0.479

High

450943

CCNF
Cyclin-F

1

2

High-throughput

0.479

High

450944

PERI
Peripherin

1

1

High-throughput

0.479

High

450945

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.479

High

450949

RECQ1
ATP-dependent DNA helicase Q1

1

3

High-throughput

0.479

High

450950

YAP1
Transcriptional coactivator YAP1

1

8

High-throughput

0.479

High

450951

TISD
mRNA decay activator protein ZFP36L2

1

2

High-throughput

0.479

High

450952

SOX2
Transcription factor SOX-2

1

3

High-throughput

0.479

High

450955

MCM2
DNA replication licensing factor MCM2

1

1

High-throughput

0.479

High

450956

GSK3B
Glycogen synthase kinase-3 beta

1

6

High-throughput

0.479

High

450959

MECP2
Methyl-CpG-binding protein 2

1

1

High-throughput

0.479

High

450960

ATX3
Ataxin-3

1

1

High-throughput

0.479

High

450962

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

2

High-throughput

0.479

High

450964

RAB25
Ras-related protein Rab-25

1

4

High-throughput

0.479

High

450966

RAC3
Ras-related C3 botulinum toxin substrate 3

1

2

High-throughput

0.479

High

450968

UBC12
NEDD8-conjugating enzyme Ubc12

1

3

High-throughput

0.479

High

450969

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

450970

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

2

High-throughput

0.479

High

450971

1433Z
14-3-3 protein zeta/delta

1

6

High-throughput

0.479

High

450972

HSF1
Heat shock factor protein 1

1

4

High-throughput

0.479

High

450973

EWS
RNA-binding protein EWS

1

5

High-throughput

0.479

High

450975

DHX9
ATP-dependent RNA helicase A

1

4

Small-scale

0.479

High

450976

EP300
Histone acetyltransferase p300

1

1

High-throughput

0.479

High

450977

ARL16
ADP-ribosylation factor-like protein 16

1

6

High-throughput

0.479

High

450978

TFCP2
Alpha-globin transcription factor CP2

1

2

High-throughput

0.479

High

450979

BIRC3
Baculoviral IAP repeat-containing protein 3

1

4

High-throughput

0.479

High

450987

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

3

High-throughput

0.479

High

450990

TNIP1
TNFAIP3-interacting protein 1

1

8

High-throughput

0.479

High

450991

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

5

High-throughput

0.479

High

450992

SETB1
Histone-lysine N-methyltransferase SETDB1

1

3

Small-scale

0.479

High

450998

ACBD5
Acyl-CoA-binding domain-containing protein 5

1

2

High-throughput

0.479

High

450999

SYDE2
Rho GTPase-activating protein SYDE2

1

4

High-throughput

0.479

High

451000

OTU1
Ubiquitin thioesterase OTU1

1

1

High-throughput

0.479

High

451001

TET5C
Terminal nucleotidyltransferase 5C

1

2

High-throughput

0.479

High

451003

A16L1
Autophagy-related protein 16-1

1

6

High-throughput

0.479

High

451004

VIR
Protein virilizer homolog

1

2

High-throughput

0.479

High

451006

ZN746
Zinc finger protein 746

1

2

High-throughput

0.479

High

451008

PRP8
Pre-mRNA-processing-splicing factor 8

1

1

High-throughput

0.479

High

451009

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.479

High

451010

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

5

High-throughput

0.479

High

451011

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.479

High

451013

MOB3C
MOB kinase activator 3C

1

1

High-throughput

0.479

High

451018

SLN11
Schlafen family member 11

1

1

Small-scale

0.479

High

451019

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

451021

MF2L2
Probable guanine nucleotide exchange factor MCF2L2

1

1

High-throughput

0.479

High

451023

ARMC8
Armadillo repeat-containing protein 8

1

1

High-throughput

0.479

High

451025

SMC5
Structural maintenance of chromosomes protein 5

1

2

High-throughput

0.479

High

451027

RPTOR
Regulatory-associated protein of mTOR

1

4

High-throughput

0.479

High

451028

RHG24
Rho GTPase-activating protein 24

1

2

High-throughput

0.479

High

451030

SERB1
SERPINE1 mRNA-binding protein 1

1

4

High-throughput

0.479

High

451034

BICD2
Protein bicaudal D homolog 2

1

6

High-throughput

0.479

High

451038

TOPB1
DNA topoisomerase 2-binding protein 1

1

5

High-throughput

0.479

High

451039

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

6

High-throughput

0.479

High

451043

EFMT3
EEF1A lysine methyltransferase 3

1

8

High-throughput

0.479

High

451045

CHM4C
Charged multivesicular body protein 4c

1

4

High-throughput

0.479

High

451050

DDRGK
DDRGK domain-containing protein 1

1

3

High-throughput

0.479

High

451051

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

451054

RUFY1
RUN and FYVE domain-containing protein 1

1

4

High-throughput

0.479

High

451056

RING2
E3 ubiquitin-protein ligase RING2

1

13

High-throughput

0.479

High

451057

NECD
Necdin

1

2

High-throughput

0.479

High

451058

ANM1
Protein arginine N-methyltransferase 1

1

6

High-throughput

0.479

High

451059

BAG1
BAG family molecular chaperone regulator 1

1

3

High-throughput

0.479

High

451060

RIOK1
Serine/threonine-protein kinase RIO1

1

1

High-throughput

0.479

High

451061

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

8

High-throughput

0.479

High

451062

FACD2
Fanconi anemia group D2 protein

1

4

High-throughput

0.479

High

451064

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

4

High-throughput

0.479

High

451065

TRI55
Tripartite motif-containing protein 55

1

9

High-throughput

0.479

High

451068

RHG39
Rho GTPase-activating protein 39

1

3

High-throughput

0.479

High

451070

SHRPN
Sharpin

1

4

Small-scale

0.479

High

451072

PKHA4
Pleckstrin homology domain-containing family A member 4

1

10

High-throughput

0.479

High

451073

ECT2
Protein ECT2

1

5

High-throughput

0.479

High

451074

NMRL1
NmrA-like family domain-containing protein 1

1

3

High-throughput

0.479

High

451076

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

4

High-throughput

0.479

High

451078

ANLN
Anillin

1

1

High-throughput

0.479

High

451083

PIHD1
PIH1 domain-containing protein 1

1

2

High-throughput

0.479

High

451086

HDAC6
Protein deacetylase HDAC6

1

11

High-throughput

0.479

High

451087

TBK1
Serine/threonine-protein kinase TBK1

1

4

High-throughput

0.479

High

451088

UBQL2
Ubiquilin-2

1

4

High-throughput

0.479

High

451089

ANC2
Anaphase-promoting complex subunit 2

1

4

High-throughput

0.479

High

451090

ACINU
Apoptotic chromatin condensation inducer in the nucleus

1

2

High-throughput

0.479

High

451091

FZR1
Fizzy-related protein homolog

1

3

High-throughput

0.479

High

451092

FAF1
FAS-associated factor 1

1

2

High-throughput

0.479

High

451094

FBW1A
F-box/WD repeat-containing protein 1A

1

2

High-throughput

0.479

High

451095

FND3A
Fibronectin type-III domain-containing protein 3A

1

6

High-throughput

0.479

High

451098

SAR1B
Small COPII coat GTPase SAR1B

1

5

High-throughput

0.479

High

126048

AP3B1
AP-3 complex subunit beta-1

1

0

High-throughput

0.458

High

128719

MEN1
Menin

1

0

High-throughput

0.458

High

176437

GRRE1
Granule associated Rac and RHOG effector protein 1

1

0

High-throughput

0.458

High

283013

PSIP1
PC4 and SFRS1-interacting protein

1

0

High-throughput

0.458

High

390419

TFR1
Transferrin receptor protein 1

1

0

High-throughput

0.458

High

450915

CO6A3

1

0

High-throughput

0.458

High

450924

IL7RA
Interleukin-7 receptor subunit alpha

1

0

High-throughput

0.458

High

450986

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

0

High-throughput

0.458

High

450995

RRP12
RRP12-like protein

1

0

High-throughput

0.458

High

451024

S35F2
Solute carrier family 35 member F2

1

0

Small-scale

0.458

High

451036

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

451040

CNOT9
CCR4-NOT transcription complex subunit 9

1

0

High-throughput

0.458

High

451042

VPP1
V-type proton ATPase 116 kDa subunit a 1

1

0

Small-scale

0.458

High

451044

F136A
Protein FAM136A

1

0

High-throughput

0.458

High

451048

VMP1
Vacuole membrane protein 1

1

0

Small-scale

0.458

High

451053

F210A
Protein FAM210A

1

0

High-throughput

0.458

High

451066

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.458

High

451077

NGB
Neuroglobin

1

0

High-throughput

0.458

High

451082

PNPO
Pyridoxine-5'-phosphate oxidase

1

0

High-throughput

0.458

High

450932

CKS2
Cyclin-dependent kinases regulatory subunit 2

1

1

Small-scale

0.457

High

450967

CKS1
Cyclin-dependent kinases regulatory subunit 1

1

1

Small-scale

0.457

High

184555

MK13
Mitogen-activated protein kinase 13

1

9

Small-scale

0.445

High

419949

B3A2
Anion exchange protein 2

1

1

High-throughput

0.445

High

450934

BMI1
Polycomb complex protein BMI-1

1

12

High-throughput

0.445

High

450980

TBB3
Tubulin beta-3 chain

1

3

High-throughput

0.445

High

451005

PKHA7
Pleckstrin homology domain-containing family A member 7

1

11

High-throughput

0.445

High

451014

TBA1A
Tubulin alpha-1A chain

1

2

High-throughput

0.445

High

451029

RYBP
RING1 and YY1-binding protein

1

1

High-throughput

0.445

High

451047

OTUB1
Ubiquitin thioesterase OTUB1

1

1

High-throughput

0.445

High

239669

PCDH7
Protocadherin-7

1

2

High-throughput

0.437

High

259315

BRD4
Bromodomain-containing protein 4

1

4

High-throughput

0.437

High

352852

AGR2
Anterior gradient protein 2 homolog

1

3

Small-scale

0.437

High

370940

MYC
Myc proto-oncogene protein

1

3

High-throughput

0.437

High

450922

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.437

High

450929

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.437

High

450936

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

450939

FUS
RNA-binding protein FUS

1

4

High-throughput

0.437

High

450953

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.437

High

450957

DNLI4
DNA ligase 4

1

2

High-throughput

0.437

High

450988

RBM39
RNA-binding protein 39

1

4

High-throughput

0.437

High

450994

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.437

High

451012

PAXI1
PAX-interacting protein 1

1

5

High-throughput

0.437

High

451015

KCTD9
BTB/POZ domain-containing protein KCTD9

1

6

High-throughput

0.437

High

451020

ZCH18
Zinc finger CCCH domain-containing protein 18

1

3

High-throughput

0.437

High

451026

SLX4
Structure-specific endonuclease subunit SLX4

1

5

High-throughput

0.437

High

451035

DCA11
DDB1- and CUL4-associated factor 11

1

1

High-throughput

0.437

High

451052

DOCK7
Dedicator of cytokinesis protein 7

1

3

High-throughput

0.437

High

451067

Z518B
Zinc finger protein 518B

1

1

High-throughput

0.437

High

451079

SLX9
Ribosome biogenesis protein SLX9 homolog

1

1

Small-scale

0.437

High

451096

AAR2
Protein AAR2 homolog

1

3

High-throughput

0.437

High

451097

PPME1
Protein phosphatase methylesterase 1

1

2

Small-scale

0.437

High

450946

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

0

Small-scale

0.426

High

451093

GLCNE
Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase

1

0

Small-scale

0.426

High

450954

CEBPA
CCAAT/enhancer-binding protein alpha

1

8

High-throughput

0.408

High

344063

PTBP3
Polypyrimidine tract-binding protein 3

1

1

High-throughput

0.407

High

429153

JUN
Transcription factor Jun

1

10

High-throughput

0.407

High

450974

P
P protein

1

2

High-throughput

0.407

High

451031

MOT11
Monocarboxylate transporter 11

1

2

High-throughput

0.407

High

451085

VGLU2
Vesicular glutamate transporter 2

1

1

High-throughput

0.407

High

450948

RAD52
DNA repair protein RAD52 homolog

1

0

Small-scale

0.279

Low

450989

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.269

Low

450919

GBRA1
Gamma-aminobutyric acid receptor subunit alpha-1

1

0

High-throughput

0.249

Low

450984

PTC1
Protein patched homolog 1

1

0

Small-scale

0.249

Low

450993

TCAL1
Transcription elongation factor A protein-like 1

1

0

High-throughput

0.249

Low

451002

OBI1
ORC ubiquitin ligase 1

1

0

High-throughput

0.249

Low

451007

NEPRO
Nucleolus and neural progenitor protein

1

0

High-throughput

0.249

Low

451069

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low

254740

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.232

Low

450997

LITD1
LINE-1 type transposase domain-containing protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025