HitPredict

Interactor 1: DDB1 (Q16531)
DNA damage-binding protein 1 (DDB p127 subunit) (DNA damage-binding protein a) (DDBa) (Damage-specific DNA-binding protein 1) (HBV X-associated protein 1) (XAP-1) (UV-damaged DNA-binding factor) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (XPE-binding factor) (XPE-BF) (Xeroderma pigmentosum group E-complementing protein) (XPCe)
Gene: DDB1

Interactor 2: WDR26 (Q9H7D7)
WD repeat-containing protein 26 (CUL4- and DDB1-associated WDR protein 2) (Myocardial ischemic preconditioning up-regulated protein 2)
Gene: WDR26

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	29911972, 17041588
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CPSF_A~WD40, MMS1_N~WD40
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 1140 Hs			1 661
+	Mm
		1112276 DDB1_MOUSE (1-1140): 0: 1422: 99.65		WDR26_MOUSE (29-661): 2.04e-156: 467: 95.89
+	Hs
		245605 DDB1_HUMAN (1-1140): 0: 1424: 100.00		TBL1X_HUMAN (396-661): 8.44e-63: 220: 19.79
+	Hs
		1082206 DDB1_HUMAN (1-1140): 0: 1424: 100.00		SMU1_HUMAN (477-661): 1.05e-44: 169: 17.41
+	Hs
		1082263 DDB1_HUMAN (1-1140): 0: 1424: 100.00		WDR5B_HUMAN (179-512): 1.46e-45: 166: 14.29
+	Hs
		903254 DDB1_HUMAN (1-1140): 0: 1424: 100.00		WDR5_HUMAN (186-512): 3.62e-45: 165: 15.18
+	Hs
		921580 DDB1_HUMAN (1-1140): 0: 1424: 100.00		GBB2_HUMAN (462-661): 1.61e-37: 144: 12.20
+	Hs
		1082229 DDB1_HUMAN (1-1140): 0: 1424: 100.00		A16L1_HUMAN (522-652): 1.81e-24: 110: 18.94
+	Mm
		1112273 DDB1_MOUSE (1-1140): 0: 1422: 99.65		A16L1_MOUSE (356-473): 6.39e-15: 80.1: 19.67
+	Hs
		1082327 DDB1_HUMAN (1-1140): 0: 1424: 100.00		SNR40_HUMAN (17-381): 1.88e-13: 74.4: 13.39
+	Hs
		1073094 SF3B3_HUMAN (3-1126): 0: 1102: 21.33		FBXW7_HUMAN (314-594): 9.42e-60: 214: 14.53
+	Hs
		1073168 SF3B3_HUMAN (3-1126): 0: 1102: 21.33		NLE1_HUMAN (45-428): 8.11e-31: 128: 15.25
+	Sc
		744701 CFT1_YEAST (11-1125): 0: 678: 14.79		TAF5_YEAST (266-618): 2.24e-72: 251: 20.48
+	Hs
		1014128 CPSF1_HUMAN (4-527): 4.39e-117: 397: 15.87		TAF5_HUMAN (450-661): 8.05e-55: 202: 14.58
+	Hs
		1014208 CPSF1_HUMAN (4-527): 4.39e-117: 397: 15.87		NLE1_HUMAN (45-428): 8.11e-31: 128: 15.25