HitPredict

Interactor 1: RBBP7 (Q16576)
Histone-binding protein RBBP7 (Histone acetyltransferase type B subunit 2) (Nucleosome-remodeling factor subunit RBAP46) (Retinoblastoma-binding protein 7) (RBBP-7) (Retinoblastoma-binding protein p46)
Gene: RBBP7

Interactor 2: PHF6 (Q8IWS0)
PHD finger protein 6 (PHD-like zinc finger protein)
Gene: PHF6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	22720776
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0042393 - histone binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 425 Hs			1 365
+	Hs
		975266 RBBP7_HUMAN (1-425): 2.38e-115: 345: 100.00		KMT2A_HUMAN (5-132): 1.13e-27: 116: 24.62
+	Hs
		1083422 RBBP7_HUMAN (1-425): 2.38e-115: 345: 100.00		TCF20_HUMAN (32-145): 1.11e-23: 105: 22.81
+	Hs
		997796 RBBP4_HUMAN (1-209): 1.59e-39: 148: 12.72		PHF6_HUMAN (1-365): 7.01e-85: 263: 100.00
+	Hs
		903604 WDR5_HUMAN (311-425): 1.28e-17: 85.2: 22.61		KMT2B_HUMAN (2-364): 8.55e-58: 204: 13.41
+	Hs
		152663 WDR5B_HUMAN (1-254): 1.38e-58: 196: 14.83		KMT2D_HUMAN (153-340): 1.77e-16: 83.4: 15.03
+	Hs
		975233 RBBP4_HUMAN (1-209): 1.59e-39: 148: 12.72		KMT2A_HUMAN (5-132): 1.13e-27: 116: 24.62
+	Hs
		997945 RBBP4_HUMAN (1-209): 1.59e-39: 148: 12.72		TCF20_HUMAN (32-145): 1.11e-23: 105: 22.81
+	Hs
		997783 RBBP4_HUMAN (1-209): 1.59e-39: 148: 12.72		RAI1_HUMAN (20-132): 3.89e-21: 97.3: 28.32
+	Hs
		256979 POC1B_HUMAN (2-170): 4.68e-36: 139: 9.77		KDM4A_HUMAN (7-141): 5.24e-24: 105: 17.14
+	Hs
		903149 WDR5_HUMAN (311-425): 1.28e-17: 85.2: 22.61		KMT2A_HUMAN (5-132): 1.13e-27: 116: 24.62
+	Hs
		301131 WDR5_HUMAN (311-425): 1.28e-17: 85.2: 22.61		KDM4B_HUMAN (7-133): 1.19e-25: 110: 17.42
+	Hs
		975315 GRWD1_HUMAN (307-404): 4.14e-14: 75.7: 23.47		KMT2A_HUMAN (5-132): 1.13e-27: 116: 24.62
+	At
		1319861 WDR5A_ARATH (2-67): 2.68e-10: 63.3: 10.61		ATX1_ARATH (5-177): 1.25e-28: 119: 17.37
+	Hs
		152622 WDR5_HUMAN (311-425): 1.28e-17: 85.2: 22.61		KMT2D_HUMAN (153-340): 1.77e-16: 83.4: 15.03
+	Mm
		903669 WDR5_MOUSE (311-425): 1.28e-17: 85.2: 22.61		KMT2C_MOUSE (134-339): 3.45e-16: 82.3: 15.05
+	Hs
		903374 WDR5_HUMAN (311-425): 1.28e-17: 85.2: 22.61		KMT2C_HUMAN (129-339): 2.08e-15: 80: 15.64
+	Hs
		152682 GRWD1_HUMAN (307-404): 4.14e-14: 75.7: 23.47		KMT2D_HUMAN (153-340): 1.77e-16: 83.4: 15.03