HitPredict

Interactor 1: CPSF6 (Q16630)
Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7)
Gene: CPSF6

Interactor 2: CSTFT (Q9H0L4)
Cleavage stimulation factor subunit 2 tau variant (CF-1 64 kDa subunit tau variant) (Cleavage stimulation factor 64 kDa subunit tau variant) (CSTF 64 kDa subunit tau variant) (TauCstF-64)
Gene: CSTF2T

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0003729 - mRNA binding GO:0005654 - nucleoplasm GO:0005847 - mRNA cleavage and polyadenylation specificity factor complex GO:0031124 - mRNA 3'-end processing
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 551 Hs			1 616
+	Hs
		703389 CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00		CSTF2_HUMAN (1-615): 8.49e-64: 222: 67.81
+	Mm
		857339 CPSF6_MOUSE (1-520): 4.58e-92: 294: 99.62		TIA1_MOUSE (11-344): 1.88e-20: 95.8: 14.36
+	Dm
		1364315 CPSF6_DROME (8-485): 1.09e-43: 166: 36.97		Q9VE52_DROME (1-320): 3.59e-52: 186: 43.60
+	Hs
		846991 SMCA4_HUMAN (126-551): 8.83e-45: 172: 15.98		RA1L2_HUMAN (1-311): 2.77e-42: 156: 14.60
+	Hs
		703436 WDR33_HUMAN (180-396): 5.21e-09: 61.5: 24.69		CSTF2_HUMAN (1-615): 8.49e-64: 222: 67.81
+	Hs
		516495 PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51		PABP1_HUMAN (7-554): 3.29e-25: 112: 10.80
+	Hs
		1104153 TGO1_HUMAN (138-380): 8.27e-13: 73.8: 25.18		RA1L2_HUMAN (1-311): 2.77e-42: 156: 14.60
+	Hs
		474021 PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51		PAB4L_HUMAN (7-95): 1.29e-21: 98.9: 24.72
+	Hs
		516339 PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40		PABP1_HUMAN (7-554): 3.29e-25: 112: 10.80
+	Hs
		516689 PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40		PABP3_HUMAN (7-201): 4.69e-24: 108: 14.72
+	Hs
		516635 PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40		PABP5_HUMAN (20-193): 1.42e-24: 107: 17.61
+	Zm
		8143 A0A1D6ELH4_MAIZE (60-456): 7.52e-26: 113: 13.55		A0A1D6ELH4_MAIZE (14-192): 1.91e-18: 91.3: 18.13
+	Mm
		665745 PABP1_MOUSE (81-518): 3.65e-24: 108: 16.63		TIA1_MOUSE (11-344): 1.88e-20: 95.8: 14.36
+	Hs
		1119141 PAP1L_HUMAN (81-485): 1.03e-19: 94.6: 12.53		PABP5_HUMAN (20-193): 1.42e-24: 107: 17.61
+	Sc
		376562 PABP_YEAST (82-174): 3.01e-12: 71.1: 27.96		PABP_YEAST (2-201): 2.88e-27: 118: 19.21
+	Sc
		376645 PABP_YEAST (82-174): 3.01e-12: 71.1: 27.96		RNA15_YEAST (16-88): 5.45e-15: 77.8: 46.58
+	Sc
		376818 PABP_YEAST (82-174): 3.01e-12: 71.1: 27.96		SGN1_YEAST (16-89): 7.7e-11: 64.7: 43.24
+	Sc
		376819 PABP_YEAST (82-174): 3.01e-12: 71.1: 27.96		IST3_YEAST (18-91): 1.59e-11: 64.3: 37.84