Protein: RRP12
Ribosomal RNA-processing protein 12

Gene: RRP12
Organism: Saccharomyces cerevisiae S288C
Interactions: 204
UniProt ID: Q12754

Gene Ontology (top 5):
GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0003723 - RNA binding
GO:0003729 - mRNA binding
GO:0005634 - nucleus
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

798363

ENP1
Essential nuclear protein 1

12

1

Small-scale

0.757

High

791139

NOP4
Nucleolar protein 4

7

1

Small-scale

0.749

High

1055538

NOC4
Nucleolar complex protein 4

7

3

Small-scale

0.743

High

1059261

TSR1
Ribosome biogenesis protein TSR1

6

2

Small-scale

0.732

High

1084544

MAK21
Ribosome biogenesis protein MAK21

6

3

High-throughput

0.730

High

678492

PWP2
Periodic tryptophan protein 2

5

3

Small-scale

0.714

High

820410

RIO2
Serine/threonine-protein kinase RIO2

4

2

Small-scale

0.691

High

1046107

DHR1
Probable ATP-dependent RNA helicase DHR1

4

2

Small-scale

0.676

High

836221

DIM1
Dimethyladenosine transferase

5

0

Small-scale

0.676

High

1050221

RRP5
rRNA biogenesis protein RRP5

4

1

Small-scale

0.672

High

924878

NOP15
Ribosome biogenesis protein 15

3

1

High-throughput

0.662

High

383968

RS17A
Small ribosomal subunit protein eS17A

2

0

High-throughput

0.660

High

677641

KRR1
KRR1 small subunit processome component

3

1

High-throughput

0.656

High

1046283

UTP15
U3 small nucleolar RNA-associated protein 15

3

1

High-throughput

0.656

High

918623

SLX9
Ribosome biogenesis protein SLX9

4

0

Small-scale

0.653

High

924672

NAT10
RNA cytidine acetyltransferase

3

1

Small-scale

0.640

High

1084586

RIO1
Serine/threonine-protein kinase RIO1

3

2

Small-scale

0.640

High

806605

UTP9
U3 small nucleolar RNA-associated protein 9

3

0

High-throughput

0.638

High

1064338

UTP16
U3 small nucleolar RNA-associated protein 16

3

0

High-throughput

0.638

High

1085063

NOP14
Nucleolar complex protein 14

3

0

High-throughput

0.638

High

734751

IMB3
Importin subunit beta-3

3

0

Small-scale

0.634

High

1084999

NOP58
Nucleolar protein 58

3

3

High-throughput

0.633

High

780353

EBP2
rRNA-processing protein EBP2

3

0

High-throughput

0.633

High

518166

SSBP1
Single-stranded nucleic acid-binding protein

2

1

High-throughput

0.619

High

1084250

NOP53
Ribosome biogenesis protein NOP53

3

0

High-throughput

0.618

High

844679

UTP10
U3 small nucleolar RNA-associated protein 10

3

0

High-throughput

0.613

High

803977

CIC1
Proteasome-interacting protein CIC1

2

2

High-throughput

0.611

High

817663

UTP7
U3 small nucleolar RNA-associated protein 7

2

2

High-throughput

0.611

High

850047

LOC1
60S ribosomal subunit assembly/export protein LOC1

2

0

High-throughput

0.607

High

751527

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

2

0

High-throughput

0.602

High

528134

HSP72
Heat shock protein SSA2

2

2

High-throughput

0.601

High

827654

RLP7
Ribosome biogenesis protein RLP7

2

3

High-throughput

0.594

High

742995

HSP79
Heat shock protein homolog SSE2

2

4

High-throughput

0.588

High

513300

RS8A
Small ribosomal subunit protein eS8A

2

1

High-throughput

0.584

High

919062

PESC
Pescadillo homolog

2

2

High-throughput

0.584

High

1056505

UTP4
U3 small nucleolar RNA-associated protein 4

2

3

Small-scale

0.584

High

1065607

BMS1
Ribosome biogenesis protein BMS1

2

2

High-throughput

0.584

High

818302

NSA2
Ribosome biogenesis protein NSA2

2

0

High-throughput

0.569

High

700315

GAR1
H/ACA ribonucleoprotein complex subunit GAR1

2

0

High-throughput

0.563

High

594661

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

0

High-throughput

0.559

High

756705

LTV1
Protein LTV1

2

0

Small-scale

0.559

High

763659

UTP20
U3 small nucleolar RNA-associated protein 20

2

0

Small-scale

0.559

High

814425

NOC2
Nucleolar complex protein 2

2

0

High-throughput

0.559

High

1046834

UTP14
U3 small nucleolar RNA-associated protein 14

2

0

High-throughput

0.559

High

1085064

PNO1
Pre-rRNA-processing protein PNO1

2

0

Small-scale

0.559

High

433323

RL17A
Large ribosomal subunit protein uL22A

1

1

High-throughput

0.536

High

525691

HSP71
Heat shock protein SSA1

1

2

High-throughput

0.536

High

546908

SSB1
Ribosome-associated molecular chaperone SSB1

1

2

High-throughput

0.536

High

570200

RL3
Large ribosomal subunit protein uL3

1

1

High-throughput

0.536

High

637310

PWP1
Periodic tryptophan protein 1

1

1

High-throughput

0.536

High

655536

RS3A2
Small ribosomal subunit protein eS1B

1

2

High-throughput

0.536

High

917521

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

4

High-throughput

0.536

High

1040439

FRK1
Fatty acyl-CoA synthetase and RNA processing-associated kinase 1

1

1

High-throughput

0.536

High

1084613

RL7B
Large ribosomal subunit protein uL30B

1

3

High-throughput

0.536

High

744954

SLA1
Actin cytoskeleton-regulatory complex protein SLA1

1

0

High-throughput

0.518

High

628245

PRP2
Pre-mRNA-splicing factor ATP-dependent RNA helicase-like protein PRP2

1

4

High-throughput

0.515

High

383380

RL28
Large ribosomal subunit protein uL15

1

0

High-throughput

0.513

High

603127

EST1
Telomere elongation protein EST1

1

0

High-throughput

0.513

High

684897

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.513

High

735283

KNS1
Dual specificity protein kinase KNS1

1

0

High-throughput

0.513

High

843294

KRI1
Protein KRI1

1

0

High-throughput

0.513

High

865574

PTK2
Serine/threonine-protein kinase PTK2/STK2

1

0

High-throughput

0.513

High

923167

BRE5
UBP3-associated protein BRE5

1

0

High-throughput

0.513

High

924040

ELOA1
Elongin-A

1

0

High-throughput

0.513

High

1030276

BCK1
Serine/threonine-protein kinase BCK1/SLK1/SSP31

1

0

High-throughput

0.513

High

1030624

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

0

High-throughput

0.513

High

1046547

PUF6
Pumilio homology domain family member 6

1

0

High-throughput

0.513

High

1055154

MAG2
E3 ubiquitin-protein ligase MAG2

1

0

High-throughput

0.513

High

1059623

NOP6
Nucleolar protein 6

1

0

High-throughput

0.513

High

1064372

DIA2
Protein DIA2

1

0

High-throughput

0.513

High

745929

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

2

Small-scale

0.501

High

1037967

NU100
Nucleoporin NUP100/NSP100

1

2

Small-scale

0.501

High

1038009

NU116
Nucleoporin NUP116/NSP116

1

2

Small-scale

0.501

High

665217

DPB2
DNA polymerase epsilon subunit B

1

0

High-throughput

0.493

High

828523

SA185
SIT4-associating protein SAP185

1

0

High-throughput

0.493

High

1065590

YP216
Putative ISWI chromatin-remodeling complex subunit YPL216W

1

0

High-throughput

0.493

High

150030

RS9A
Small ribosomal subunit protein uS4A

1

2

High-throughput

0.479

High

410417

RL25
Large ribosomal subunit protein uL23

1

1

High-throughput

0.479

High

435463

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.479

High

436249

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.479

High

442192

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.479

High

455338

RS19A
Small ribosomal subunit protein eS19A

1

1

High-throughput

0.479

High

512733

RS6A
Small ribosomal subunit protein eS6A

1

1

High-throughput

0.479

High

513601

RL1A
Large ribosomal subunit protein uL1A

1

3

High-throughput

0.479

High

664636

PRP22
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22

1

4

Small-scale

0.479

High

671287

SIS1
Protein SIS1

1

1

High-throughput

0.479

High

674915

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.479

High

747067

IMP3
U3 small nucleolar ribonucleoprotein protein IMP3

1

2

High-throughput

0.479

High

747663

RSSA1
Small ribosomal subunit protein uS2A

1

2

High-throughput

0.479

High

753670

RS3A1
Small ribosomal subunit protein eS1A

1

2

High-throughput

0.479

High

754362

DCA13
Protein SOF1

1

1

High-throughput

0.479

High

782124

RL1D1
Ribosome biogenesis protein UTP30

1

2

High-throughput

0.479

High

792331

GBLP
Small ribosomal subunit protein RACK1

1

1

High-throughput

0.479

High

793552

MAK5
ATP-dependent RNA helicase MAK5

1

5

High-throughput

0.479

High

802927

DBP8
ATP-dependent RNA helicase DBP8

1

1

High-throughput

0.479

High

808333

RRP8
25S rRNA

1

1

High-throughput

0.479

High

825580

UTP25
U3 small nucleolar RNA-associated protein 25

1

1

High-throughput

0.479

High

826127

ULP2
Ubiquitin-like-specific protease 2

1

1

High-throughput

0.479

High

863158

RRP41
Exosome complex component SKI6

1

1

High-throughput

0.479

High

923277

ESF2
Pre-rRNA-processing protein ESF2

1

1

High-throughput

0.479

High

925175

APJ1
J domain-containing protein APJ1

1

1

High-throughput

0.479

High

963820

H3
Histone H3

1

2

High-throughput

0.479

High

1038131

ULP1
Ubiquitin-like-specific protease 1

1

1

High-throughput

0.479

High

1039672

NOG1
Nucleolar GTP-binding protein 1

1

1

High-throughput

0.479

High

1039883

UTP17
NET1-associated nuclear protein 1

1

3

High-throughput

0.479

High

1043324

HAS1
ATP-dependent RNA helicase HAS1

1

3

High-throughput

0.479

High

1044530

RUVB1
RuvB-like protein 1

1

1

High-throughput

0.479

High

1045136

UTP5
U3 small nucleolar RNA-associated protein 5

1

3

High-throughput

0.479

High

1051629

HRQ1
ATP-dependent helicase HRQ1

1

2

Small-scale

0.479

High

1051732

RRP45
Exosome complex component RRP45

1

2

High-throughput

0.479

High

1053141

UTP13
U3 small nucleolar RNA-associated protein 13

1

5

High-throughput

0.479

High

1053543

UTP21
U3 small nucleolar RNA-associated protein 21

1

4

High-throughput

0.479

High

1055455

RRP9
Ribosomal RNA-processing protein 9

1

3

High-throughput

0.479

High

1056337

BFR2
Protein BFR2

1

1

High-throughput

0.479

High

1064845

RS10A
Small ribosomal subunit protein eS10A

1

1

High-throughput

0.479

High

1084631

UTP12
U3 small nucleolar RNA-associated protein 12

1

4

High-throughput

0.479

High

1084709

RRP42
Exosome complex component RRP42

1

2

High-throughput

0.479

High

1084946

NOP56
Nucleolar protein 56

1

3

High-throughput

0.479

High

1084965

RUVB2
RuvB-like protein 2

1

1

High-throughput

0.479

High

1085012

CMR1
DNA damage-binding protein CMR1

1

2

High-throughput

0.479

High

403717

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

0

Small-scale

0.458

High

433921

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.458

High

436560

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

0

High-throughput

0.458

High

488643

RIR2
Ribonucleoside-diphosphate reductase small chain 1

1

0

Small-scale

0.458

High

512179

RS4A
Small ribosomal subunit protein eS4A

1

0

High-throughput

0.458

High

514910

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

558912

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.458

High

647259

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.458

High

649258

SAN1
Protein SAN1

1

0

Small-scale

0.458

High

662062

PSB6
Proteasome subunit beta type-6

1

0

High-throughput

0.458

High

672989

RRP43
Exosome complex component RRP43

1

0

High-throughput

0.458

High

673260

RRP7
Ribosomal RNA-processing protein 7

1

0

High-throughput

0.458

High

677989

YCQ6
Uncharacterized protein YCR016W

1

0

High-throughput

0.458

High

689741

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.458

High

708651

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

735244

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

758433

UTP11
U3 small nucleolar RNA-associated protein 11

1

0

High-throughput

0.458

High

778610

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

782191

LAS1
Protein LAS1

1

0

Small-scale

0.458

High

782508

RPF2
Ribosome biogenesis protein RPF2

1

0

Small-scale

0.458

High

800691

KPR2
Ribose-phosphate pyrophosphokinase 2

1

0

High-throughput

0.458

High

802466

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.458

High

804772

RRP4
Exosome complex component RRP4

1

0

High-throughput

0.458

High

804980

LRP1
Exosome complex protein LRP1

1

0

High-throughput

0.458

High

823417

UTP18
U3 small nucleolar RNA-associated protein 18

1

0

High-throughput

0.458

High

825104

RRT14
Regulator of rDNA transcription protein 14

1

0

High-throughput

0.458

High

826235

FAF1
Protein FAF1

1

0

High-throughput

0.458

High

826974

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

852633

ROK1
ATP-dependent RNA helicase ROK1

1

0

High-throughput

0.458

High

864564

MTR4
ATP-dependent RNA helicase DOB1

1

0

High-throughput

0.458

High

864988

NOP9
Nucleolar protein 9

1

0

Small-scale

0.458

High

865201

MPP10
U3 small nucleolar RNA-associated protein MPP10

1

0

High-throughput

0.458

High

865439

URB2
Nucleolar pre-ribosomal-associated protein 2

1

0

High-throughput

0.458

High

865812

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.458

High

866270

YJ9I
Uncharacterized protein YJR141W

1

0

Small-scale

0.458

High

871083

NOL10
Ribosome biogenesis protein ENP2

1

0

High-throughput

0.458

High

874610

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

917589

NSA1
Ribosome biogenesis protein NSA1

1

0

High-throughput

0.458

High

918507

EIF2A
Eukaryotic translation initiation factor 2A

1

0

High-throughput

0.458

High

918867

UTP22
U3 small nucleolar RNA-associated protein 22

1

0

High-throughput

0.458

High

919204

UTP8
U3 small nucleolar RNA-associated protein 8

1

0

High-throughput

0.458

High

923072

TR112
Multifunctional methyltransferase subunit TRM112

1

0

Small-scale

0.458

High

924007

CSL4
Exosome complex component CSL4

1

0

High-throughput

0.458

High

924141

SQS1
Protein SQS1

1

0

High-throughput

0.458

High

925225

IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

1

0

High-throughput

0.458

High

1033651

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

1036438

UTP6
U3 small nucleolar RNA-associated protein 6

1

0

High-throughput

0.458

High

1038778

XRN2
5'-3' exoribonuclease 2

1

0

High-throughput

0.458

High

1044323

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

0

High-throughput

0.458

High

1044921

RRP17
Ribosomal RNA-processing protein 17

1

0

High-throughput

0.458

High

1046336

VMS1
tRNA endonuclease VMS1

1

0

High-throughput

0.458

High

1051182

FCF1
rRNA-processing protein FCF1

1

0

High-throughput

0.458

High

1054029

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

1054563

NEP1
Ribosomal RNA small subunit methyltransferase NEP1

1

0

High-throughput

0.458

High

1059450

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.458

High

1060766

CMS1
Protein CMS1

1

0

High-throughput

0.458

High

1061654

RCL1
rRNA processing protein RCL1

1

0

High-throughput

0.458

High

1062924

RRP40
Exosome complex component RRP40

1

0

High-throughput

0.458

High

1064094

NOB1
20S-pre-rRNA D-site endonuclease NOB1

1

0

Small-scale

0.458

High

1064312

SGO1
Shugoshin

1

0

High-throughput

0.458

High

1084168

FCF2
rRNA-processing protein FCF2

1

0

High-throughput

0.458

High

1084363

SAS10
Something about silencing protein 10

1

0

High-throughput

0.458

High

1084982

RRP36
rRNA biogenesis protein RRP36

1

0

High-throughput

0.458

High

577360

NSP1
Nucleoporin NSP1

1

2

Small-scale

0.457

High

531946

RL4A
Large ribosomal subunit protein uL4A

1

1

High-throughput

0.445

High

676510

MAS5
Mitochondrial protein import protein MAS5

1

1

High-throughput

0.445

High

742776

HSP7F
Heat shock protein homolog SSE1

1

4

High-throughput

0.445

High

804597

SSZ1
Ribosome-associated complex subunit SSZ1

1

1

High-throughput

0.445

High

820230

SSB2
Ribosome-associated molecular chaperone SSB2

1

2

High-throughput

0.445

High

504493

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.437

High

365719

PGK
Phosphoglycerate kinase

1

0

High-throughput

0.426

High

592608

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.426

High

727440

HS104
Heat shock protein 104

1

0

High-throughput

0.426

High

816761

PFD2
Prefoldin subunit 2

1

0

High-throughput

0.426

High

1025207

SEN1
Helicase SEN1

1

0

Small-scale

0.426

High

1084779

HSP42
Heat shock protein 42

1

0

High-throughput

0.426

High

503319

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

503870

RL27A
Large ribosomal subunit protein eL27A

1

0

High-throughput

0.249

Low

736215

YBT1
ATP-dependent bile acid permease

1

0

Small-scale

0.249

Low

812804

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

1025077

NUM1
Nuclear migration protein NUM1

1

0

High-throughput

0.249

Low

1065551

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low

368091

ENO2
Enolase 2

1

0

High-throughput

0.232

Low

801128

FKS1
1,3-beta-glucan synthase component FKS1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025