HitPredict

Interactor 1: HIF1A (Q16665)
Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8)
Gene: HIF1A

Interactor 2: MED15 (Q96RN5)
Mediator of RNA polymerase II transcription subunit 15 (Activator-recruited cofactor 105 kDa component) (ARC105) (CTG repeat protein 7a) (Mediator complex subunit 15) (Positive cofactor 2 glutamine/Q-rich-associated protein) (PC2 glutamine/Q-rich-associated protein) (TPA-inducible gene 1 protein) (TIG-1) (Trinucleotide repeat-containing gene 7 protein)
Gene: MED15

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	23746844
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 826 Hs			1 788
+	Hs
		554312 HIF1A_HUMAN (1-826): 0: 741: 100.00		MUC1_HUMAN (72-625): 3.94e-26: 117: 8.26
+	Hs
		1301086 EPAS1_HUMAN (4-824): 5.7e-171: 518: 41.24		MED15_HUMAN (1-788): 2.62e-102: 335: 100.00
+	Hs
		1085646 HIF1A_HUMAN (1-826): 0: 741: 100.00		EP400_HUMAN (236-579): 1.3e-19: 97: 20.00
+	Hs
		1085623 HIF1A_HUMAN (1-826): 0: 741: 100.00		CBP_HUMAN (139-583): 4.11e-10: 65.9: 11.24
+	Rn
		193481 HIF1A_RAT (1-826): 0: 714: 89.40		CBP_RAT (139-583): 1.38e-09: 64: 11.63
+	Hs
		1270775 EPAS1_HUMAN (4-824): 5.7e-171: 518: 41.24		CBP_HUMAN (139-583): 4.11e-10: 65.9: 11.24
+	Hs
		160168 NPAS2_HUMAN (5-749): 1.34e-113: 367: 18.32		HGS_HUMAN (71-479): 3.22e-23: 107: 18.08
+	Hs
		1075384 NCOA2_HUMAN (1-747): 3.97e-109: 367: 15.62		CBP_HUMAN (139-583): 4.11e-10: 65.9: 11.24
+	Hs
		1270774 NPAS2_HUMAN (5-749): 1.34e-113: 367: 18.32		CBP_HUMAN (139-583): 4.11e-10: 65.9: 11.24
+	Mm
		799605 BMAL1_MOUSE (7-505): 2.8e-116: 368: 20.92		CBP_MOUSE (147-583): 8.96e-10: 64.8: 11.19
+	Hs
		126156 BMAL1_HUMAN (7-505): 9.03e-114: 361: 20.88		CBP_HUMAN (139-583): 4.11e-10: 65.9: 11.24
+	Hs
		181549 CLOCK_HUMAN (2-696): 1.68e-102: 338: 18.24		CBP_HUMAN (139-583): 4.11e-10: 65.9: 11.24
+	Mm
		101411 CLOCK_MOUSE (2-704): 2.25e-102: 338: 17.88		F8VPR5_MOUSE (147-583): 8.96e-10: 64.8: 11.19
+	Hs
		1270854 NCOA3_HUMAN (1-746): 4.42e-98: 335: 15.31		CBP_HUMAN (139-583): 4.11e-10: 65.9: 11.24
+	Ce
		108089 HIF1_CAEEL (8-535): 5.37e-95: 314: 23.28		UNC89_CAEEL (72-508): 1.09e-13: 77.8: 8.74
+	Mm
		799600 BMAL2_MOUSE (13-508): 3.25e-100: 324: 20.86		CBP_MOUSE (147-583): 8.96e-10: 64.8: 11.19