HitPredict

Interactor 1: HIF1A (Q16665)
Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8)
Gene: HIF1A

Interactor 2: UN45A (Q9H3U1)
Protein unc-45 homolog A (Unc-45A) (GCUNC-45) (Smooth muscle cell-associated protein 1) (SMAP-1)
Gene: UNC45A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	27320910
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016607 - nuclear speck GO:0051879 - Hsp90 protein binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 826 Hs			1 944
+	Hs
		1085653 HIF1A_HUMAN (1-826): 0: 741: 100.00		TTC1_HUMAN (11-172): 2.98e-40: 152: 28.49
+	Hs
		1085720 HIF1A_HUMAN (1-826): 0: 741: 100.00		CHIP_HUMAN (8-159): 1.54e-35: 139: 29.30
+	Hs
		1306553 EPAS1_HUMAN (4-824): 5.7e-171: 518: 41.24		CHIP_HUMAN (8-159): 1.54e-35: 139: 29.30
+	Hs
		1050583 SIM2_HUMAN (19-659): 3.6e-127: 397: 27.21		Q9BPW0_HUMAN (10-180): 2.23e-39: 154: 23.98
+	Hs
		858623 SIM2_HUMAN (19-659): 3.6e-127: 397: 27.21		PPP5_HUMAN (10-180): 3.77e-39: 154: 23.98
+	Hs
		1050582 SIM2_HUMAN (19-659): 3.6e-127: 397: 27.21		TTC1_HUMAN (11-172): 2.98e-40: 152: 28.49
+	Hs
		213544 SIM2_HUMAN (19-659): 3.6e-127: 397: 27.21		SGTA_HUMAN (1-141): 4.45e-39: 149: 27.66
+	Hs
		1050593 SIM2_HUMAN (19-659): 3.6e-127: 397: 27.21		CHIP_HUMAN (8-159): 1.54e-35: 139: 29.30
+	Hs
		728969 AHR_HUMAN (7-745): 4.08e-113: 366: 15.97		CHIP_HUMAN (8-159): 1.54e-35: 139: 29.30
+	Hs
		126180 BMAL1_HUMAN (7-505): 9.03e-114: 361: 20.88		CHIP_HUMAN (8-159): 1.54e-35: 139: 29.30
+	Hs
		728925 AHR_HUMAN (7-745): 4.08e-113: 366: 15.97		TOM34_HUMAN (2-139): 4.73e-31: 126: 27.54
+	Hs
		684713 SIM2_HUMAN (19-659): 3.6e-127: 397: 27.21		STIP1_HUMAN (4-228): 9.18e-17: 86.8: 15.32
+	Hs
		181570 CLOCK_HUMAN (2-696): 1.68e-102: 338: 18.24		CHIP_HUMAN (8-159): 1.54e-35: 139: 29.30
+	Dm
		247725 CLOCK_DROME (20-458): 1.11e-95: 323: 21.67		Q9VH81_DROME (6-180): 1.39e-38: 153: 22.29
+	Hs
		1306179 NPAS1_HUMAN (1-505): 3.83e-104: 335: 27.19		CHIP_HUMAN (8-159): 1.54e-35: 139: 29.30
+	Hs
		1050592 SIM2_HUMAN (19-659): 3.6e-127: 397: 27.21		FKBPL_HUMAN (25-135): 1.26e-11: 69.3: 37.93
+	Hs
		1078485 NPAS1_HUMAN (1-505): 3.83e-104: 335: 27.19		TOM34_HUMAN (2-139): 4.73e-31: 126: 27.54
+	Dm
		247717 CLOCK_DROME (20-458): 1.11e-95: 323: 21.67		Q7KJA9_DROME (48-469): 9.79e-18: 90.7: 11.87