HitPredict

Interactor 1: H2A2C (Q16777)
Histone H2A type 2-C (H2A-clustered histone 20) (Histone H2A-GL101) (Histone H2A/q)
Gene: H2AC20

Interactor 2: BRE1A (Q5VTR2)
E3 ubiquitin-protein ligase BRE1A (BRE1-A) (hBRE1) (EC 2.3.2.27) (RING finger protein 20) (RING-type E3 ubiquitin transferase BRE1A)
Gene: RNF20

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	21443952
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 129 Hs			1 975
+	Hs
		1138171 H2A2A_HUMAN (1-127): 3.37e-65: 195: 97.64		BRE1A_HUMAN (1-975): 1.48e-77: 275: 100.00
+	Hs
		391741 H2A1B_HUMAN (1-127): 8.29e-65: 194: 94.49		BRE1A_HUMAN (1-975): 1.48e-77: 275: 100.00
+	Hs
		256199 H2A1B_HUMAN (1-127): 8.29e-65: 194: 94.49		BRE1B_HUMAN (1-974): 4.61e-62: 230: 56.49
+	Sc
		392215 H2A1_YEAST (16-129): 1.56e-52: 163: 78.95		BRE1_YEAST (509-974): 2.63e-58: 215: 19.14
+	Sc
		392585 H2A2_YEAST (16-129): 1.63e-52: 163: 78.95		BRE1_YEAST (509-974): 2.63e-58: 215: 19.14
+	Hs
		149187 H2A1A_HUMAN (1-129): 1.77e-67: 201: 92.25		CTRO_HUMAN (49-890): 9.97e-15: 81.5: 14.94
+	Hs
		148877 H2A2C_HUMAN (1-129): 7.11e-67: 199: 100.00		CTRO_HUMAN (49-890): 9.97e-15: 81.5: 14.94
+	Hs
		149019 H2A2B_HUMAN (1-126): 2.4e-66: 198: 96.83		CTRO_HUMAN (49-890): 9.97e-15: 81.5: 14.94
+	Hs
		149235 H2AJ_HUMAN (1-129): 1.81e-66: 198: 96.90		CTRO_HUMAN (49-890): 9.97e-15: 81.5: 14.94
+	Hs
		728498 H2A1C_HUMAN (1-127): 4.25e-65: 195: 96.06		MYH11_HUMAN (586-956): 8.4e-15: 81.7: 11.61
+	Hs
		148317 H2A1_HUMAN (1-127): 5.35e-65: 195: 96.06		CTRO_HUMAN (49-890): 9.97e-15: 81.5: 14.94
+	Hs
		148937 H2A2A_HUMAN (1-127): 3.37e-65: 195: 97.64		CTRO_HUMAN (49-890): 9.97e-15: 81.5: 14.94
+	Hs
		148983 H2A3_HUMAN (1-127): 5.35e-65: 195: 95.28		CTRO_HUMAN (49-890): 9.97e-15: 81.5: 14.94
+	Hs
		149144 H2A1C_HUMAN (1-127): 4.25e-65: 195: 96.06		CTRO_HUMAN (49-890): 9.97e-15: 81.5: 14.94
+	Hs
		148275 H2A1B_HUMAN (1-127): 8.29e-65: 194: 94.49		CTRO_HUMAN (49-890): 9.97e-15: 81.5: 14.94
+	Hs
		148390 H2A1D_HUMAN (1-127): 6.03e-65: 194: 95.28		CTRO_HUMAN (49-890): 9.97e-15: 81.5: 14.94
+	Hs
		148361 H2AX_HUMAN (1-123): 7.38e-64: 192: 95.12		CTRO_HUMAN (49-890): 9.97e-15: 81.5: 14.94
+	Hs
		391578 H2A1B_HUMAN (1-127): 8.29e-65: 194: 94.49		MYH10_HUMAN (604-944): 1.39e-12: 74.4: 10.85