HitPredict

Interactor 1: H2B2E (Q16778)
Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q)
Gene: H2BC21

Interactor 2: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	0.60	0.619

Property	Details
Experiments	35271311, 12626569
Identification Methods	affinity chromatography technology, enzymatic study, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 126 Hs			1 488
+	Hs
		1270408 H2B1M_HUMAN (1-126): 5.38e-54: 166: 96.03		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		707699 H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		1270409 H2B1L_HUMAN (1-126): 2.49e-52: 162: 97.62		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		1231218 H2B3B_HUMAN (1-126): 1.01e-51: 161: 96.03		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		1270361 H2B1A_HUMAN (1-126): 3.43e-46: 147: 85.04		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		1038424 H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		918340 H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		707620 H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		1038530 H2B3B_HUMAN (1-126): 1.01e-51: 161: 96.03		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		1038606 H2B1A_HUMAN (1-126): 3.43e-46: 147: 85.04		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		177352 H2B1A_HUMAN (1-126): 3.43e-46: 147: 85.04		HDAC3_HUMAN (10-431): 0: 574: 58.26
+	At
		1322590 H2B10_ARATH (3-125): 1.12e-43: 141: 59.71		HDA6_ARATH (1-467): 0: 578: 57.02
+	Sp
		140569 H2B1_SCHPO (4-125): 1.24e-45: 145: 70.49		PHD1_SCHPO (7-411): 0: 519: 52.56
+	Sc
		355947 H2B2_YEAST (3-125): 4.73e-37: 124: 71.55		HOS2_YEAST (11-430): 5.02e-174: 498: 47.18
+	Hs
		1307130 H2B1M_HUMAN (1-126): 5.38e-54: 166: 96.03		HDAC6_HUMAN (11-363): 6.94e-102: 332: 24.04
+	Hs
		241656 H2B1K_HUMAN (1-126): 1.56e-53: 165: 98.41		HDAC6_HUMAN (11-363): 6.94e-102: 332: 24.04
+	Sc
		355966 H2B2_YEAST (3-125): 4.73e-37: 124: 71.55		HDA1_YEAST (9-330): 1.24e-121: 373: 27.56
+	Hs
		707778 H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41		HDAC6_HUMAN (11-363): 6.94e-102: 332: 24.04
+	Hs
		886211 H2B1D_HUMAN (1-126): 3.5e-53: 164: 98.41		HDAC6_HUMAN (11-363): 6.94e-102: 332: 24.04
+	Hs
		1307148 H2B1L_HUMAN (1-126): 2.49e-52: 162: 97.62		HDAC6_HUMAN (11-363): 6.94e-102: 332: 24.04