HitPredict

Interactor 1: H2B2E (Q16778)
Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q)
Gene: H2BC21

Interactor 2: UBP7 (Q93009)
Ubiquitin carboxyl-terminal hydrolase 7 (EC 3.4.19.12) (Deubiquitinating enzyme 7) (Herpesvirus-associated ubiquitin-specific protease) (Ubiquitin thioesterase 7) (Ubiquitin-specific-processing protease 7)
Gene: USP7

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	25605328, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 126 Hs			1 1102
+	Hs
		707705 H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41		UBP7_HUMAN (1-1102): 0: 1165: 100.00
+	Hs
		1231220 H2B3B_HUMAN (1-126): 1.01e-51: 161: 96.03		UBP7_HUMAN (1-1102): 0: 1165: 100.00
+	Dm
		355274 H2B_DROME (36-126): 9.49e-47: 148: 95.60		UBP7_DROME (5-1102): 0: 932: 48.00
+	Hs
		420851 H2B1J_HUMAN (1-126): 7.8e-54: 166: 99.21		UBP48_HUMAN (206-572): 1.45e-102: 349: 26.90
+	Hs
		918483 H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21		UBP48_HUMAN (206-572): 1.45e-102: 349: 26.90
+	Hs
		707674 H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41		UBP48_HUMAN (206-572): 1.45e-102: 349: 26.90
+	Hs
		1087489 H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00		UBP22_HUMAN (45-521): 2.51e-107: 347: 16.43
+	Mm
		500577 H2B1F_MOUSE (1-126): 9.91e-53: 163: 98.41		UBP48_MOUSE (206-572): 1.33e-102: 349: 27.45
+	Hs
		707794 H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41		UBP22_HUMAN (45-521): 2.51e-107: 347: 16.43
+	Hs
		1087411 H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00		UBP42_HUMAN (162-683): 1.67e-95: 334: 18.44
+	Hs
		420891 H2B1J_HUMAN (1-126): 7.8e-54: 166: 99.21		UBP36_HUMAN (165-651): 1.45e-94: 328: 18.13
+	Hs
		241654 H2B1K_HUMAN (1-126): 1.56e-53: 165: 98.41		UBP36_HUMAN (165-651): 1.45e-94: 328: 18.13
+	Hs
		707772 H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41		UBP36_HUMAN (165-651): 1.45e-94: 328: 18.13
+	Hs
		707665 H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41		UBP51_HUMAN (61-525): 3.06e-95: 321: 16.58
+	Hs
		905383 H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00		UBP46_HUMAN (204-522): 1.27e-91: 299: 25.50
+	Hs
		905394 H2B1H_HUMAN (1-126): 6.27e-54: 166: 98.41		UBP46_HUMAN (204-522): 1.27e-91: 299: 25.50
+	Hs
		259286 H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00		UBP12_HUMAN (189-522): 1.4e-89: 294: 25.55
+	Sc
		355943 H2B2_YEAST (3-125): 4.73e-37: 124: 71.55		UBP8_YEAST (131-519): 2.12e-90: 300: 21.98
+	Sc
		355547 H2B1_YEAST (3-125): 1.81e-36: 122: 71.55		UBP8_YEAST (131-519): 2.12e-90: 300: 21.98