HitPredict

Interactor 1: H2B2E (Q16778)
Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q)
Gene: H2BC21

Interactor 2: BARD1 (Q99728)
BRCA1-associated RING domain protein 1 (BARD-1) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase BARD1)
Gene: BARD1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	1.00	0.799

Property	Details
Experiments	29180510, 35271311
Identification Methods	enzymatic study, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Histone~zf-RING_6
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0046982 - protein heterodimerization activity
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 126 Hs			1 777
+	Hs
		918638 H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21		BARD1_HUMAN (1-777): 0: 663: 100.00
+	Hs
		707725 H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41		BARD1_HUMAN (1-777): 0: 663: 100.00
+	Hs
		862088 H2B1H_HUMAN (1-126): 6.27e-54: 166: 98.41		DAPK1_HUMAN (194-574): 1.25e-79: 281: 15.62
+	Hs
		1087361 H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00		MPP8_HUMAN (119-549): 1.23e-51: 195: 15.51
+	Hs
		918634 H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21		MPP8_HUMAN (119-549): 1.23e-51: 195: 15.51
+	Hs
		1087208 H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00		BCOR_HUMAN (152-543): 1.16e-44: 176: 23.93
+	Hs
		918460 H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21		BCOR_HUMAN (152-543): 1.16e-44: 176: 23.93
+	Hs
		918458 H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21		ANR11_HUMAN (280-544): 1.17e-42: 170: 25.74
+	Hs
		241562 H2B1K_HUMAN (1-126): 1.56e-53: 165: 98.41		ANR11_HUMAN (280-544): 1.17e-42: 170: 25.74
+	Hs
		918605 H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21		TONSL_HUMAN (423-532): 1.15e-20: 99.8: 46.90
+	Hs
		1293187 H2B1L_HUMAN (1-126): 2.49e-52: 162: 97.62		TONSL_HUMAN (423-532): 1.15e-20: 99.8: 46.90
+	Hs
		1231225 H2B3B_HUMAN (1-126): 1.01e-51: 161: 96.03		TONSL_HUMAN (423-532): 1.15e-20: 99.8: 46.90
+	Hs
		276167 H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21		PSD10_HUMAN (272-468): 6e-18: 85.3: 11.94
+	Hs
		1282944 H2B1A_HUMAN (1-126): 3.43e-46: 147: 85.04		TONSL_HUMAN (423-532): 1.15e-20: 99.8: 46.90