HitPredict

Interactor 1: H2B2E (Q16778)
Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q)
Gene: H2BC21

Interactor 2: NP1L4 (Q99733)
Nucleosome assembly protein 1-like 4 (Nucleosome assembly protein 2) (NAP-2)
Gene: NAP1L4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	1.00	0.799

Property	Details
Experiments	9325046, 35271311
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Histone~NAP
Common GO terms	GO:0005634 - nucleus GO:0006334 - nucleosome assembly
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 126 Hs			1 375
+	Hs
		420873 H2B1J_HUMAN (1-126): 7.8e-54: 166: 99.21		NP1L4_HUMAN (1-375): 2.5e-142: 410: 100.00
+	Hs
		707727 H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41		NP1L4_HUMAN (1-375): 2.5e-142: 410: 100.00
+	Hs
		1231232 H2B3B_HUMAN (1-126): 1.01e-51: 161: 96.03		NP1L4_HUMAN (1-375): 2.5e-142: 410: 100.00
+	Hs
		1282951 H2B1A_HUMAN (1-126): 3.43e-46: 147: 85.04		NP1L4_HUMAN (1-375): 2.5e-142: 410: 100.00
+	Hs
		876745 H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21		NP1L1_HUMAN (21-336): 1.38e-123: 363: 67.72
+	Hs
		876805 H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00		NP1L1_HUMAN (21-336): 1.38e-123: 363: 67.72
+	Hs
		707565 H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41		NP1L1_HUMAN (21-336): 1.38e-123: 363: 67.72
+	Hs
		876845 H2B3B_HUMAN (1-126): 1.01e-51: 161: 96.03		NP1L1_HUMAN (21-336): 1.38e-123: 363: 67.72
+	Hs
		876869 H2B1A_HUMAN (1-126): 3.43e-46: 147: 85.04		NP1L1_HUMAN (21-336): 1.38e-123: 363: 67.72
+	Dm
		355262 H2B_DROME (36-126): 9.49e-47: 148: 95.60		Q24150_DROME (55-340): 2.54e-109: 326: 51.05
+	Dm
		355275 H2B_DROME (36-126): 9.49e-47: 148: 95.60		Q9W1G7_DROME (55-340): 2.04e-109: 326: 51.05
+	Ce
		1090450 H2B2_CAEEL (5-126): 5.3e-50: 156: 78.69		Q19007_CAEEL (40-363): 3.1e-91: 278: 36.70
+	Ce
		380429 H2B1_CAEEL (6-126): 9.38e-50: 156: 78.51		Q19007_CAEEL (40-363): 3.1e-91: 278: 36.70
+	Sc
		355792 H2B2_YEAST (3-125): 4.73e-37: 124: 71.55		NAP1_YEAST (14-338): 4.8e-95: 291: 33.94
+	Sc
		355362 H2B1_YEAST (3-125): 1.81e-36: 122: 71.55		NAP1_YEAST (14-338): 4.8e-95: 291: 33.94
+	Hs
		707676 H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41		TSYL5_HUMAN (112-368): 1.78e-63: 210: 15.00
+	Hs
		707747 H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41		TSYL1_HUMAN (113-336): 1.52e-63: 210: 17.86
+	Hs
		886086 H2B1D_HUMAN (1-126): 3.5e-53: 164: 98.41		SET_HUMAN (92-336): 2.56e-62: 203: 20.82
+	Hs
		963873 H2B1A_HUMAN (1-126): 3.43e-46: 147: 85.04		SET_HUMAN (92-336): 2.56e-62: 203: 20.82
+	Hs
		420872 H2B1J_HUMAN (1-126): 7.8e-54: 166: 99.21		NP1L5_HUMAN (7-115): 1.27e-21: 92.9: 36.70