HitPredict

Interactor 1: TRAF1 (Q13077)
TNF receptor-associated factor 1 (Epstein-Barr virus-induced protein 6)
Gene: TRAF1

Interactor 2: TRADD (Q15628)
Tumor necrosis factor receptor type 1-associated DEATH domain protein (TNFR1-associated DEATH domain protein) (TNFRSF1A-associated via death domain)
Gene: TRADD

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	1.00	0.836

Property	Details
Experiments	8565075, 19287455, 18439848
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	TRADD_N~TRAF-mep_MATH
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006915 - apoptotic process GO:0033209 - tumor necrosis factor-mediated signaling pathway GO:0035591 - signaling adaptor activity
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 416 Hs			1 312
+	Hs
		1090657 TRAF2_HUMAN (3-415): 5.31e-124: 370: 38.01		TRADD_HUMAN (1-312): 0: 526: 100.00
+	Hs
		1150582 TRAF6_HUMAN (15-414): 3.23e-103: 317: 22.98		TRADD_HUMAN (1-312): 0: 526: 100.00
+	Hs
		1094901 TRAF3_HUMAN (3-262): 8.09e-11: 65.7: 15.77		TRADD_HUMAN (1-312): 0: 526: 100.00