Protein: TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein (TNFR1-associated DEATH domain protein) (TNFRSF1A-associated via death domain)

Gene: TRADD
Organism: Homo sapiens
Interactions: 135
UniProt ID: Q15628

Gene Ontology (top 5):
GO:0002947 - tumor necrosis factor receptor superfamily complex
GO:0005068 - transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

622618

TNR1A
Tumor necrosis factor receptor superfamily member 1A

39

10

Small-scale

0.994

High

1090657

TRAF2
TNF receptor-associated factor 2

18

3

Small-scale

0.989

High

1096900

FADD
FAS-associated death domain protein

14

5

Small-scale

0.980

High

1109600

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

7

2

Small-scale

0.965

High

1150534

TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein

4

0

Small-scale

0.854

High

1094901

TRAF3
TNF receptor-associated factor 3

3

3

Small-scale

0.843

High

1093825

TRAF1
TNF receptor-associated factor 1

3

3

Small-scale

0.836

High

1150557

TNR25
Tumor necrosis factor receptor superfamily member 25

2

10

Small-scale

0.800

High

378101

TNFA
Tumor necrosis factor

18

1

Small-scale

0.762

High

284510

TNR21
Tumor necrosis factor receptor superfamily member 21

2

10

Small-scale

0.754

High

1107404

BIRC2
Baculoviral IAP repeat-containing protein 2

2

0

Small-scale

0.748

High

1132368

CASP8
Caspase-8

8

1

Small-scale

0.748

High

127679

TR10A
Tumor necrosis factor receptor superfamily member 10A

1

9

Small-scale

0.618

High

163303

TR10B
Tumor necrosis factor receptor superfamily member 10B

1

10

Small-scale

0.618

High

466578

TNR16
Tumor necrosis factor receptor superfamily member 16

1

10

Small-scale

0.618

High

675038

TNR6
Tumor necrosis factor receptor superfamily member 6

1

9

Small-scale

0.618

High

1150582

TRAF6
TNF receptor-associated factor 6

1

3

Small-scale

0.618

High

1150584

NEMO
NF-kappa-B essential modulator

2

1

Small-scale

0.611

High

349676

BPNT1
3'(2'),5'-bisphosphate nucleotidase 1

2

0

High-throughput

0.602

High

353874

BCL10
B-cell lymphoma/leukemia 10

1

0

Small-scale

0.586

High

1150547

CCAR2
Cell cycle and apoptosis regulator protein 2

2

0

High-throughput

0.585

High

630281

TNR1B
Tumor necrosis factor receptor superfamily member 1B

2

9

Small-scale

0.584

High

436877

K1C18
Keratin, type I cytoskeletal 18

1

4

Small-scale

0.573

High

838104

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

0

Small-scale

0.537

High

1150549

NEDD1
Protein NEDD1

1

1

High-throughput

0.536

High

1150574

RCC2
Protein RCC2

1

1

High-throughput

0.536

High

1150544

TMC8
Transmembrane channel-like protein 8

1

0

Small-scale

0.529

High

1150560

OPTN
Optineurin

1

1

Small-scale

0.515

High

74501

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

0

High-throughput

0.513

High

209274

PRP4
U4/U6 small nuclear ribonucleoprotein Prp4

1

0

High-throughput

0.513

High

217267

ARK72
Aflatoxin B1 aldehyde reductase member 2

1

0

High-throughput

0.513

High

280920

HYPM
Huntingtin-interacting protein M

1

0

High-throughput

0.513

High

326438

S1PR2
Sphingosine 1-phosphate receptor 2

1

0

High-throughput

0.513

High

398004

KLKB1
Plasma kallikrein

1

0

High-throughput

0.513

High

445181

S10A6
Protein S100-A6

1

0

High-throughput

0.513

High

479422

SRP19
Signal recognition particle 19 kDa protein

1

0

High-throughput

0.513

High

639249

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

0

High-throughput

0.513

High

717820

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

0

Small-scale

0.513

High

829217

RFC3
Replication factor C subunit 3

1

0

High-throughput

0.513

High

851042

AFAM
Afamin

1

0

High-throughput

0.513

High

890489

RBP2
E3 SUMO-protein ligase RanBP2

1

0

High-throughput

0.513

High

1023785

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

0

High-throughput

0.513

High

1100796

G3BP1
Ras GTPase-activating protein-binding protein 1

1

0

High-throughput

0.513

High

1137714

TNIP1
TNFAIP3-interacting protein 1

1

0

High-throughput

0.513

High

1150535

UB2V2
Ubiquitin-conjugating enzyme E2 variant 2

1

0

High-throughput

0.513

High

1150536

PKN2
Serine/threonine-protein kinase N2

1

0

High-throughput

0.513

High

1150537

HERC4
Probable E3 ubiquitin-protein ligase HERC4

1

0

High-throughput

0.513

High

1150540

DEN5A
DENN domain-containing protein 5A

1

0

High-throughput

0.513

High

1150541

ULK3
Serine/threonine-protein kinase ULK3

1

0

High-throughput

0.513

High

1150543

PDPN
Podoplanin

1

0

High-throughput

0.513

High

1150546

CHSS2
Chondroitin sulfate synthase 2

1

0

High-throughput

0.513

High

1150548

NLGN1
Neuroligin-1

1

0

High-throughput

0.513

High

1150550

THOC2
THO complex subunit 2

1

0

High-throughput

0.513

High

1150553

THAP4
Peroxynitrite isomerase THAP4

1

0

High-throughput

0.513

High

1150564

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

0

High-throughput

0.513

High

1150565

NUP85
Nuclear pore complex protein Nup85

1

0

High-throughput

0.513

High

1150569

ANTR1
Anthrax toxin receptor 1

1

0

High-throughput

0.513

High

1150570

MINY3
Ubiquitin carboxyl-terminal hydrolase MINDY-3

1

0

High-throughput

0.513

High

1150575

TEN3
Teneurin-3

1

0

High-throughput

0.513

High

1150576

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.513

High

1150583

RN115
E3 ubiquitin-protein ligase RNF115

1

0

High-throughput

0.513

High

624070

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

0

High-throughput

0.493

High

1150538

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

Small-scale

0.493

High

1150539

DAB2P
Disabled homolog 2-interacting protein

1

0

Small-scale

0.493

High

1150551

TP4AP
Short transient receptor potential channel 4-associated protein

1

0

Small-scale

0.493

High

1150559

SH3K1
SH3 domain-containing kinase-binding protein 1

1

0

Small-scale

0.493

High

172845

XPO1
Exportin-1

1

1

High-throughput

0.479

High

189169

IPO8
Importin-8

1

2

High-throughput

0.479

High

334780

IPO7
Importin-7

1

2

High-throughput

0.479

High

408070

TBB4A
Tubulin beta-4A chain

1

1

High-throughput

0.479

High

420548

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

1

High-throughput

0.479

High

424910

ADT2
ADP/ATP translocase 2

1

1

High-throughput

0.479

High

457459

TBB5
Tubulin beta chain

1

1

High-throughput

0.479

High

461510

HS90A
Heat shock protein HSP 90-alpha

1

1

High-throughput

0.479

High

468403

HS90B
Heat shock protein HSP 90-beta

1

1

High-throughput

0.479

High

507199

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

1

High-throughput

0.479

High

537211

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

552252

ADT3
ADP/ATP translocase 3

1

1

High-throughput

0.479

High

598095

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

1

High-throughput

0.479

High

761407

HS71L
Heat shock 70 kDa protein 1-like

1

1

High-throughput

0.479

High

1024366

S25A3
Solute carrier family 25 member 3

1

2

High-throughput

0.479

High

1129316

TRIPC
E3 ubiquitin-protein ligase TRIP12

1

1

Small-scale

0.479

High

1134210

IMB1
Importin subunit beta-1

1

1

High-throughput

0.479

High

1150558

RIFK
Riboflavin kinase

1

1

Small-scale

0.479

High

1150562

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

1

Small-scale

0.479

High

1150579

EDAR
Tumor necrosis factor receptor superfamily member EDAR

1

7

Small-scale

0.479

High

1150556

APBB2
Amyloid beta precursor protein binding family B member 2

1

0

Small-scale

0.460

High

166786

IFIT3
Interferon-induced protein with tetratricopeptide repeats 3

1

0

Small-scale

0.458

High

288415

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

0

Small-scale

0.458

High

293738

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

348514

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

0

High-throughput

0.458

High

474696

VIME
Vimentin

1

0

High-throughput

0.458

High

658196

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

697543

PYR1
Multifunctional protein CAD

1

0

High-throughput

0.458

High

727818

DNJA1
DnaJ homolog subfamily A member 1

1

0

High-throughput

0.458

High

840714

RS27
Small ribosomal subunit protein eS27

1

0

High-throughput

0.458

High

842767

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

0

Small-scale

0.458

High

936757

NP1L1
Nucleosome assembly protein 1-like 1

1

0

High-throughput

0.458

High

969878

RS16
Small ribosomal subunit protein uS9

1

0

High-throughput

0.458

High

993187

ACTG
Actin, cytoplasmic 2

1

0

High-throughput

0.458

High

1008167

PRKDC
DNA-dependent protein kinase catalytic subunit

1

0

High-throughput

0.458

High

1026048

CLH1
Clathrin heavy chain 1

1

0

High-throughput

0.458

High

1041080

CAV1
Caveolin-1

1

0

Small-scale

0.458

High

1051754

EF1A2
Elongation factor 1-alpha 2

1

0

High-throughput

0.458

High

1058033

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1063770

LG3BP
Galectin-3-binding protein

1

0

High-throughput

0.458

High

1107745

SQSTM
Sequestosome-1

1

0

Small-scale

0.458

High

1146229

ZMY11
Zinc finger MYND domain-containing protein 11

1

0

Small-scale

0.458

High

1150542

MAVS
Mitochondrial antiviral-signaling protein

1

0

Small-scale

0.458

High

1150555

TANK
TRAF family member-associated NF-kappa-B activator

1

0

Small-scale

0.458

High

1150567

HIPK2
Homeodomain-interacting protein kinase 2

1

0

Small-scale

0.458

High

1150571

PDLI7
PDZ and LIM domain protein 7

1

0

Small-scale

0.458

High

1150578

SPAT2
Spermatogenesis-associated protein 2

1

0

Small-scale

0.458

High

385113

K1C14
Keratin, type I cytoskeletal 14

1

3

Small-scale

0.457

High

1150552

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

1

1

Small-scale

0.445

High

1150580

Q9UQC1
Heat shock protein 72

1

2

High-throughput

0.437

High

1150581

DRG1
Developmentally-regulated GTP-binding protein 1

1

0

High-throughput

0.426

High

228718

U3IP2
U3 small nucleolar RNA-interacting protein 2

1

0

High-throughput

0.279

Low

339983

RPA1
DNA-directed RNA polymerase I subunit RPA1

1

0

High-throughput

0.279

Low

634946

MIME
Mimecan

1

0

High-throughput

0.279

Low

1038866

PLOD1
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1

1

0

High-throughput

0.279

Low

1093463

COASY
Bifunctional coenzyme A synthase

1

0

High-throughput

0.279

Low

1150545

UEVLD
Ubiquitin-conjugating enzyme E2 variant 3

1

0

High-throughput

0.279

Low

1150554

PCSK5
Proprotein convertase subtilisin/kexin type 5

1

0

High-throughput

0.279

Low

1150561

DUS3L
tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like

1

0

High-throughput

0.279

Low

1150563

HPLN3
Hyaluronan and proteoglycan link protein 3

1

0

High-throughput

0.279

Low

1150566

C1QT3
Complement C1q tumor necrosis factor-related protein 3

1

0

High-throughput

0.279

Low

1150568

NOL6
Nucleolar protein 6

1

0

High-throughput

0.279

Low

1150572

CHSTC
Carbohydrate sulfotransferase 12

1

0

High-throughput

0.279

Low

1150577

PCOC2
Procollagen C-endopeptidase enhancer 2

1

0

High-throughput

0.279

Low

318014

TOM70
Mitochondrial import receptor subunit TOM70

1

0

Small-scale

0.249

Low

1124961

RCN2
Reticulocalbin-2

1

0

High-throughput

0.249

Low

1150573

ATD3A
ATPase family AAA domain-containing protein 3A

1

0

High-throughput

0.249

Low

389602

RET4
Retinol-binding protein 4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025