HitPredict

Interactor 1: H2L2C8 (H2L2C8)
Alpha-actinin, sarcomeric
Gene: atn-1

Interactor 2: SEM5 (P29355)
Sex muscle abnormal protein 5
Gene: sem-5

Species: Caenorhabditis elegans

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.639

Property	Details
Experiments	12679813, 10615043, 14704431
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 823 Ce			1 228
+	Ce
		666217 Q23158_CAEEL (1-823): 0: 553: 95.41		SEM5_CAEEL (1-228): 9.03e-71: 217: 100.00
+	Hs
		924555 SPTN1_HUMAN (218-688): 5.92e-20: 97.9: 13.29		GRB2_HUMAN (1-214): 5.56e-66: 204: 57.60
+	Hs
		924482 SPTB2_HUMAN (183-767): 2.83e-14: 79.7: 13.85		GRB2_HUMAN (1-214): 5.56e-66: 204: 57.60
+	Hs
		211557 ACTN4_HUMAN (82-802): 5.6e-13: 75: 13.23		GRB2_HUMAN (1-214): 5.56e-66: 204: 57.60
+	Hs
		521521 ACTN1_HUMAN (82-823): 7.22e-13: 74.6: 12.64		GRB2_HUMAN (1-214): 5.56e-66: 204: 57.60
+	Hs
		337470 SPTN1_HUMAN (218-688): 5.92e-20: 97.9: 13.29		ABL1_HUMAN (4-140): 3.2e-24: 102: 38.73
+	Hs
		1045423 SPTN1_HUMAN (218-688): 5.92e-20: 97.9: 13.29		ITSN1_HUMAN (110-222): 1.4e-13: 71.5: 19.17
+	Rn
		192738 SPTN1_RAT (215-680): 6.43e-19: 94.8: 15.86		SRBS2_RAT (86-228): 4.43e-13: 70: 20.67
+	Hs
		411715 SPTN1_HUMAN (218-688): 5.92e-20: 97.9: 13.29		LCK_HUMAN (138-228): 4.97e-12: 66.5: 18.28
+	Hs
		433753 SPTN1_HUMAN (218-688): 5.92e-20: 97.9: 13.29		LYN_HUMAN (89-212): 1.12e-10: 62.5: 21.43
+	Hs
		211480 ACTN4_HUMAN (82-802): 5.6e-13: 75: 13.23		SRC_HUMAN (57-226): 3.34e-16: 78.9: 16.28
+	Hs
		521454 ACTN1_HUMAN (82-823): 7.22e-13: 74.6: 12.64		SRC_HUMAN (57-226): 3.34e-16: 78.9: 16.28
+	Hs
		164551 SPTN2_HUMAN (174-815): 2.77e-16: 86.2: 11.68		LCK_HUMAN (138-228): 4.97e-12: 66.5: 18.28
+	Hs
		963335 SPTB2_HUMAN (183-767): 2.83e-14: 79.7: 13.85		ITSN1_HUMAN (110-222): 1.4e-13: 71.5: 19.17
+	Hs
		164555 SPTN2_HUMAN (174-815): 2.77e-16: 86.2: 11.68		LYN_HUMAN (89-212): 1.12e-10: 62.5: 21.43
+	Hs
		411676 SPTB2_HUMAN (183-767): 2.83e-14: 79.7: 13.85		LCK_HUMAN (138-228): 4.97e-12: 66.5: 18.28
+	Hs
		211443 ACTN4_HUMAN (82-802): 5.6e-13: 75: 13.23		SRBS2_HUMAN (37-222): 2.01e-12: 68.1: 18.52
+	Mm
		1113251 ACTN1_MOUSE (82-823): 2.33e-12: 72.7: 12.89		SRBS2_MOUSE (49-222): 3.98e-13: 70: 20.67
+	Hs
		298946 ACTN1_HUMAN (82-823): 7.22e-13: 74.6: 12.64		SRBS2_HUMAN (37-222): 2.01e-12: 68.1: 18.52
+	Hs
		433700 SPTB2_HUMAN (183-767): 2.83e-14: 79.7: 13.85		LYN_HUMAN (89-212): 1.12e-10: 62.5: 21.43