HitPredict

Interactor 1: PICAL (Q13492)
Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia protein)
Gene: PICALM

Interactor 2: AP2M1 (Q96CW1)
AP-2 complex subunit mu (AP-2 mu chain) (Adaptin-mu2) (Adaptor protein complex AP-2 subunit mu) (Adaptor-related protein complex 2 subunit mu) (Clathrin assembly protein complex 2 mu medium chain) (Clathrin coat assembly protein AP50) (Clathrin coat-associated protein AP50) (HA2 50 kDa subunit) (Plasma membrane adaptor AP-2 50 kDa protein)
Gene: AP2M1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

The method score is based on:

Property	Details
Experiments	26496610, 24067654
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005905 - clathrin-coated pit GO:0006900 - vesicle budding from membrane GO:0008021 - synaptic vesicle and 9 others more... GO:0016192 - vesicle-mediated transport GO:0031623 - receptor internalization GO:0045334 - clathrin-coated endocytic vesicle GO:0050750 - low-density lipoprotein particle receptor binding GO:0065003 - protein-containing complex assembly GO:0072583 - clathrin-dependent endocytosis GO:0097494 - regulation of vesicle size GO:0098894 - extrinsic component of presynaptic endocytic zone membrane GO:1903077 - negative regulation of protein localization to plasma membrane
Homologous interactions	1

Homologous interactions

Color coding for hit scores

	1	652
Hs

1	435

Service provided by Combinatics, Japan

Last updated: 11Aug2025