Protein: PICAL
Phosphatidylinositol-binding clathrin assembly protein (Clathrin assembly lymphoid myeloid leukemia protein)

Gene: PICAL, PICALM
Organism: Homo sapiens
Interactions: 238
UniProt ID: Q13492

Gene Ontology (top 5):
GO:0000149 - SNARE binding
GO:0001540 - amyloid-beta binding
GO:0005545 - 1-phosphatidylinositol binding
GO:0005546 - phosphatidylinositol-4,5-bisphosphate binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1107538

EPN4
Clathrin interactor 1

3

11

High-throughput

0.871

High

252761

AP180
Clathrin coat assembly protein AP180

2

7

High-throughput

0.776

High

241601

PRKN
E3 ubiquitin-protein ligase parkin

2

4

High-throughput

0.754

High

271702

HIP1R
Huntingtin-interacting protein 1-related protein

1

10

High-throughput

0.691

High

135926

P3C2A
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

3

3

High-throughput

0.675

High

922428

CLH2
Clathrin heavy chain 2

3

11

High-throughput

0.675

High

1107625

BMP2K
BMP-2-inducible protein kinase

3

15

High-throughput

0.675

High

1107630

GTSE1
G2 and S phase-expressed protein 1

3

4

High-throughput

0.675

High

839755

EPS15
Epidermal growth factor receptor substrate 15

3

10

High-throughput

0.670

High

483083

CLCA
Clathrin light chain A

3

7

High-throughput

0.667

High

483332

CLCB
Clathrin light chain B

3

7

High-throughput

0.667

High

1107639

MYO6
Unconventional myosin-VI

3

5

Small-scale

0.656

High

1026016

CLH1
Clathrin heavy chain 1

2

11

Small-scale

0.639

High

344682

AP2A1
AP-2 complex subunit alpha-1

2

15

High-throughput

0.628

High

1107542

RBP1
RalA-binding protein 1

2

2

High-throughput

0.628

High

1107593

STALP
AMSH-like protease

2

2

High-throughput

0.628

High

425486

ISG15
Ubiquitin-like protein ISG15

1

8

High-throughput

0.618

High

988959

AP2B1
AP-2 complex subunit beta

2

14

High-throughput

0.611

High

1107591

AP2M1
AP-2 complex subunit mu

2

1

Small-scale

0.611

High

505557

ATX1L
Ataxin-1-like

2

1

High-throughput

0.606

High

927279

ATX1
Ataxin-1

2

1

High-throughput

0.606

High

1107585

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

2

0

High-throughput

0.602

High

955136

CDC42
Cell division control protein 42 homolog

2

16

High-throughput

0.595

High

329448

EPN2
Epsin-2

1

12

High-throughput

0.590

High

1107646

EPN1
Epsin-1

1

11

High-throughput

0.590

High

411882

NTRK1
High affinity nerve growth factor receptor

2

9

High-throughput

0.584

High

977986

RHOB
Rho-related GTP-binding protein RhoB

2

18

High-throughput

0.584

High

1107596

ZC3HA
Zinc finger CCCH domain-containing protein 10

2

0

High-throughput

0.580

High

552957

PIP
Prolactin-inducible protein

2

0

High-throughput

0.576

High

619781

VCAM1
Vascular cell adhesion protein 1

2

3

High-throughput

0.571

High

1107537

FHL2
Four and a half LIM domains protein 2

1

0

Small-scale

0.561

High

209996

CRX
Cone-rod homeobox protein

1

2

High-throughput

0.560

High

994519

YBOX1
Y-box-binding protein 1

2

0

Small-scale

0.559

High

563725

CFTR
Cystic fibrosis transmembrane conductance regulator

2

1

High-throughput

0.552

High

1107589

RBPMS
RNA-binding protein with multiple splicing

1

0

High-throughput

0.536

High

47979

RBM47
RNA-binding protein 47

1

1

High-throughput

0.536

High

171699

GAK
Cyclin-G-associated kinase

1

14

High-throughput

0.536

High

175029

SC16A
Protein transport protein Sec16A

1

4

High-throughput

0.536

High

193104

DDX3Y
ATP-dependent RNA helicase DDX3Y

1

3

High-throughput

0.536

High

269955

AUXI
Auxilin

1

7

High-throughput

0.536

High

389343

FINC
Fibronectin

1

2

High-throughput

0.536

High

487276

PARP1
Poly [ADP-ribose] polymerase 1

1

3

High-throughput

0.536

High

535026

BIP
Endoplasmic reticulum chaperone BiP

1

1

High-throughput

0.536

High

650739

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

2

High-throughput

0.536

High

733344

CCR1
C-C chemokine receptor type 1

1

3

High-throughput

0.536

High

772784

MYH9
Myosin-9

1

3

High-throughput

0.536

High

788011

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

1

High-throughput

0.536

High

854036

KI67
Proliferation marker protein Ki-67

1

4

High-throughput

0.536

High

866669

CAZA2
F-actin-capping protein subunit alpha-2

1

2

High-throughput

0.536

High

938212

SEC13
Protein SEC13 homolog

1

4

High-throughput

0.536

High

1022157

DAB2
Disabled homolog 2

1

2

High-throughput

0.536

High

1070494

FCHO2
F-BAR domain only protein 2

1

3

High-throughput

0.536

High

1107533

SNW1
SNW domain-containing protein 1

1

4

High-throughput

0.536

High

1107547

DREB
Drebrin

1

5

High-throughput

0.536

High

1107559

MTSS2
Protein MTSS 2

1

1

High-throughput

0.536

High

1107562

MICA3
[F-actin]-monooxygenase MICAL3

1

3

High-throughput

0.536

High

1107564

POGZ
Pogo transposable element with ZNF domain

1

2

High-throughput

0.536

High

1107574

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.536

High

1107575

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

2

High-throughput

0.536

High

1107580

DEN1A
DENN domain-containing protein 1A

1

1

High-throughput

0.536

High

1107587

STON2
Stonin-2

1

1

High-throughput

0.536

High

1107595

MYO19
Unconventional myosin-XIX

1

7

High-throughput

0.536

High

1107600

CDC5L
Cell division cycle 5-like protein

1

1

High-throughput

0.536

High

1107603

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

4

High-throughput

0.536

High

1107606

RBM38
RNA-binding protein 38

1

4

High-throughput

0.536

High

1107622

ANLN
Anillin

1

1

High-throughput

0.536

High

1107623

MBNL1
Muscleblind-like protein 1

1

1

High-throughput

0.536

High

1107635

LIMA1
LIM domain and actin-binding protein 1

1

3

High-throughput

0.536

High

1107645

WIF1
Wnt inhibitory factor 1

1

2

High-throughput

0.536

High

105879

APRIO
Alternative prion protein

2

4

High-throughput

0.533

High

274565

DNJB6
DnaJ homolog subfamily B member 6

1

0

High-throughput

0.513

High

347003

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.513

High

417418

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.513

High

418107

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.513

High

725010

HXA11
Homeobox protein Hox-A11

1

0

High-throughput

0.513

High

813080

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

0

High-throughput

0.513

High

963562

DAD1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1

1

0

High-throughput

0.513

High

1107535

SCRB2
Lysosome membrane protein 2

1

0

High-throughput

0.513

High

1107536

MLEC
Malectin

1

0

High-throughput

0.513

High

1107553

H2A2A
Histone H2A type 2-A

1

0

High-throughput

0.513

High

1107561

CENPQ
Centromere protein Q

1

0

High-throughput

0.513

High

1107568

ZN444
Zinc finger protein 444

1

0

High-throughput

0.513

High

1107576

BBS1
BBSome complex member BBS1

1

0

High-throughput

0.513

High

1107578

STT3B
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

1

0

High-throughput

0.513

High

1107582

DOK4
Docking protein 4

1

0

High-throughput

0.513

High

1107594

VMP1
Vacuole membrane protein 1

1

0

High-throughput

0.513

High

1107627

MED17
Mediator of RNA polymerase II transcription subunit 17

1

0

High-throughput

0.513

High

1107641

SIAT9
Lactosylceramide alpha-2,3-sialyltransferase

1

0

High-throughput

0.513

High

1107643

NTNG1
Netrin-G1

1

0

High-throughput

0.513

High

155661

FCHO1
F-BAR domain only protein 1

1

3

Small-scale

0.501

High

185665

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

3

High-throughput

0.501

High

619054

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

2

Small-scale

0.501

High

1107621

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

4

Small-scale

0.501

High

1107549

PRC2B
Protein PRRC2B

1

4

High-throughput

0.489

High

1107616

PAAT
ATPase PAAT

1

2

High-throughput

0.489

High

1107544

ITSN1
Intersectin-1

1

6

High-throughput

0.481

High

126581

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.479

High

141467

DDX3X
ATP-dependent RNA helicase DDX3X

1

3

Small-scale

0.479

High

157331

CTRO
Citron Rho-interacting kinase

1

2

High-throughput

0.479

High

172784

XPO1
Exportin-1

1

5

High-throughput

0.479

High

189553

STX7
Syntaxin-7

1

2

High-throughput

0.479

High

218152

TGON2
Trans-Golgi network integral membrane protein 2

1

4

High-throughput

0.479

High

226023

STX6
Syntaxin-6

1

1

High-throughput

0.479

High

290311

KS6A4
Ribosomal protein S6 kinase alpha-4

1

3

High-throughput

0.479

High

299182

FLOT1
Flotillin-1

1

1

High-throughput

0.479

High

323710

AP2A2
AP-2 complex subunit alpha-2

1

15

High-throughput

0.479

High

330940

KI20A
Kinesin-like protein KIF20A

1

2

High-throughput

0.479

High

341048

DIRA3
GTP-binding protein Di-Ras3

1

4

High-throughput

0.479

High

363240

EGFR
Epidermal growth factor receptor

1

7

High-throughput

0.479

High

375490

RASK
GTPase KRas

1

5

High-throughput

0.479

High

485122

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

2

High-throughput

0.479

High

541471

FGFR1
Fibroblast growth factor receptor 1

1

7

High-throughput

0.479

High

556063

CADH1
Cadherin-1

1

1

High-throughput

0.479

High

560386

IFM1
Interferon-induced transmembrane protein 1

1

1

High-throughput

0.479

High

562043

LAMP2
Lysosome-associated membrane glycoprotein 2

1

2

High-throughput

0.479

High

565372

ITA4
Integrin alpha-4

1

1

High-throughput

0.479

High

581027

RAC2
Ras-related C3 botulinum toxin substrate 2

1

12

High-throughput

0.479

High

588628

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

601276

RHOQ
Rho-related GTP-binding protein RhoQ

1

18

High-throughput

0.479

High

603968

CXA1
Gap junction alpha-1 protein

1

3

High-throughput

0.479

High

651313

CBL
E3 ubiquitin-protein ligase CBL

1

4

High-throughput

0.479

High

680348

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

3

High-throughput

0.479

High

687669

SYTC
Threonine--tRNA ligase 1, cytoplasmic

1

1

High-throughput

0.479

High

695386

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

710226

EPHA2
Ephrin type-A receptor 2

1

4

High-throughput

0.479

High

715573

MARCS
Myristoylated alanine-rich C-kinase substrate

1

5

High-throughput

0.479

High

731263

STIP1
Stress-induced-phosphoprotein 1

1

3

High-throughput

0.479

High

748799

ICAM3
Intercellular adhesion molecule 3

1

4

High-throughput

0.479

High

799080

BRCA1
Breast cancer type 1 susceptibility protein

1

3

High-throughput

0.479

High

832364

OPRD
Delta-type opioid receptor

1

4

Small-scale

0.479

High

845632

MUC18
Cell surface glycoprotein MUC18

1

1

High-throughput

0.479

High

867100

CAPZB
F-actin-capping protein subunit beta

1

2

High-throughput

0.479

High

872300

SOX2
Transcription factor SOX-2

1

3

High-throughput

0.479

High

888039

MCM2
DNA replication licensing factor MCM2

1

1

High-throughput

0.479

High

891150

GSK3A
Glycogen synthase kinase-3 alpha

1

4

High-throughput

0.479

High

891523

GSK3B
Glycogen synthase kinase-3 beta

1

4

High-throughput

0.479

High

908110

KS6A3
Ribosomal protein S6 kinase alpha-3

1

3

High-throughput

0.479

High

931846

EPHA5
Ephrin type-A receptor 5

1

4

High-throughput

0.479

High

953430

RAC3
Ras-related C3 botulinum toxin substrate 3

1

14

High-throughput

0.479

High

962733

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.479

High

975020

ARF6
ADP-ribosylation factor 6

1

1

High-throughput

0.479

High

976250

RB11A
Ras-related protein Rab-11A

1

1

High-throughput

0.479

High

988343

RAC1
Ras-related C3 botulinum toxin substrate 1

1

14

High-throughput

0.479

High

1015419

RHOG
Rho-related GTP-binding protein RhoG

1

12

High-throughput

0.479

High

1031360

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.479

High

1034153

ROR1
Inactive tyrosine-protein kinase transmembrane receptor ROR1

1

13

High-throughput

0.479

High

1034225

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

8

High-throughput

0.479

High

1107534

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

6

High-throughput

0.479

High

1107540

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

1107541

RAB35
Ras-related protein Rab-35

1

2

High-throughput

0.479

High

1107543

KS6A1
Ribosomal protein S6 kinase alpha-1

1

3

High-throughput

0.479

High

1107545

NTRK3
NT-3 growth factor receptor

1

8

High-throughput

0.479

High

1107546

OCLN
Occludin

1

1

High-throughput

0.479

High

1107551

A16L1
Autophagy-related protein 16-1

1

5

High-throughput

0.479

High

1107552

RNF43
E3 ubiquitin-protein ligase RNF43

1

1

High-throughput

0.479

High

1107554

LTOR1
Ragulator complex protein LAMTOR1

1

1

High-throughput

0.479

High

1107556

STYK1
Tyrosine-protein kinase STYK1

1

4

High-throughput

0.479

High

1107557

SYNE3
Nesprin-3

1

4

High-throughput

0.479

High

1107558

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.479

High

1107560

RHOU
Rho-related GTP-binding protein RhoU

1

18

High-throughput

0.479

High

1107563

ATG9A
Autophagy-related protein 9A

1

3

High-throughput

0.479

High

1107567

SMC5
Structural maintenance of chromosomes protein 5

1

3

High-throughput

0.479

High

1107569

RHG18
Rho GTPase-activating protein 18

1

1

High-throughput

0.479

High

1107583

SMAP2
Stromal membrane-associated protein 2

1

1

High-throughput

0.479

High

1107588

MY18A
Unconventional myosin-XVIIIa

1

5

High-throughput

0.479

High

1107598

RHOV
Rho-related GTP-binding protein RhoV

1

16

High-throughput

0.479

High

1107601

ATF6B
Cyclic AMP-dependent transcription factor ATF-6 beta

1

1

High-throughput

0.479

High

1107609

DNJC5
DnaJ homolog subfamily C member 5

1

4

High-throughput

0.479

High

1107610

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

4

Small-scale

0.479

High

1107611

WNK1
Serine/threonine-protein kinase WNK1

1

5

High-throughput

0.479

High

1107612

RHOJ
Rho-related GTP-binding protein RhoJ

1

18

High-throughput

0.479

High

1107613

PKHA4
Pleckstrin homology domain-containing family A member 4

1

9

High-throughput

0.479

High

1107617

ECT2
Protein ECT2

1

2

High-throughput

0.479

High

1107618

WDR76
WD repeat-containing protein 76

1

5

High-throughput

0.479

High

1107620

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.479

High

1107632

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

2

High-throughput

0.479

High

1107634

HDAC6
Protein deacetylase HDAC6

1

2

High-throughput

0.479

High

1107640

ALK
ALK tyrosine kinase receptor

1

9

High-throughput

0.479

High

1107642

LAMP3
Lysosome-associated membrane glycoprotein 3

1

2

High-throughput

0.479

High

1107644

KLH20
Kelch-like protein 20

1

1

High-throughput

0.479

High

1107619

PELI2
E3 ubiquitin-protein ligase pellino homolog 2

1

0

High-throughput

0.460

High

1107638

TEN1
Teneurin-1

1

0

Small-scale

0.460

High

316843

MTA2
Metastasis-associated protein MTA2

1

0

High-throughput

0.458

High

327254

ZFPL1
Zinc finger protein-like 1

1

0

High-throughput

0.458

High

416017

CP1A1
Cytochrome P450 1A1

1

0

High-throughput

0.458

High

627328

AT2B1
Plasma membrane calcium-transporting ATPase 1

1

0

High-throughput

0.458

High

714089

PML
Protein PML

1

0

High-throughput

0.458

High

851116

ACHA4
Neuronal acetylcholine receptor subunit alpha-4

1

0

High-throughput

0.458

High

897794

CDK9
Cyclin-dependent kinase 9

1

0

High-throughput

0.458

High

1026882

FKBP3
Peptidyl-prolyl cis-trans isomerase FKBP3

1

0

High-throughput

0.458

High

1107539

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

Small-scale

0.458

High

1107548

FSCN1
Fascin

1

0

High-throughput

0.458

High

1107565

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1107566

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

High-throughput

0.458

High

1107581

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1107592

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

0

Small-scale

0.458

High

1107599

FMNL2
Formin-like protein 2

1

0

High-throughput

0.458

High

1107604

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

1107608

PTN23
Tyrosine-protein phosphatase non-receptor type 23

1

0

Small-scale

0.458

High

1107629

MTMR4
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4

1

0

High-throughput

0.458

High

1107631

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1107633

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

0

Small-scale

0.458

High

1107637

GGA2
ADP-ribosylation factor-binding protein GGA2

1

0

Small-scale

0.458

High

472710

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

2

High-throughput

0.457

High

1030638

ANK2
Ankyrin-2

1

3

High-throughput

0.457

High

1091390

ANK3
Ankyrin-3

1

3

High-throughput

0.457

High

1107636

BAZ2B
Bromodomain adjacent to zinc finger domain protein 2B

1

4

High-throughput

0.457

High

104007

F5GWT4
non-specific serine/threonine protein kinase

1

5

High-throughput

0.445

High

765479

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.445

High

1107555

PKHA7
Pleckstrin homology domain-containing family A member 7

1

10

High-throughput

0.445

High

1107605

ZDHC5
Palmitoyltransferase ZDHHC5

1

2

High-throughput

0.445

High

1107626

DDX28
Probable ATP-dependent RNA helicase DDX28

1

4

High-throughput

0.445

High

1107573

NECA1
N-terminal EF-hand calcium-binding protein 1

1

0

High-throughput

0.438

High

1107584

SNX33
Sorting nexin-33

1

0

High-throughput

0.438

High

1107597

ZN521
Zinc finger protein 521

1

0

High-throughput

0.438

High

768120

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

1107590

CK052
Uncharacterized protein C11orf52

1

1

High-throughput

0.437

High

1107607

S2532
Solute carrier family 25 member 32

1

1

High-throughput

0.437

High

1107628

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

2

High-throughput

0.437

High

397952

ANGI
Angiogenin

1

0

High-throughput

0.426

High

1033973

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

0

High-throughput

0.426

High

1107550

LITD1
LINE-1 type transposase domain-containing protein 1

1

0

High-throughput

0.426

High

1107579

MIPT3
TRAF3-interacting protein 1

1

2

High-throughput

0.417

High

1107602

PIMRE
Protein PIMREG

2

0

High-throughput

0.318

High

298706

ATP5H
ATP synthase peripheral stalk subunit d, mitochondrial

2

0

High-throughput

0.305

High

505157

OST4
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4

1

0

High-throughput

0.279

Low

1107571

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

0

High-throughput

0.279

Low

1107572

KTAP2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2

1

0

High-throughput

0.279

Low

1107577

RDH11
Retinol dehydrogenase 11

1

0

High-throughput

0.279

Low

1107614

CSTP1
Centriolar satellite-associated tubulin polyglutamylase complex regulator 1

1

0

High-throughput

0.279

Low

1107615

CCSE2
Serine-rich coiled-coil domain-containing protein 2

1

0

High-throughput

0.279

Low

1107624

OSTC
Oligosaccharyltransferase complex subunit OSTC

1

0

High-throughput

0.279

Low

353310

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

1107570

S2541
Mitochondrial carrier protein SCaMC-3L

1

0

High-throughput

0.249

Low

1107586

ITLN1
Intelectin-1

1

0

High-throughput

0.249

Low

421155

SCG1
Secretogranin-1

1

0

High-throughput

0.238

Low

516837

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

1

0

High-throughput

0.232

Low

1103950

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025