HitPredict

Interactor 1: SQSTM (Q13501)
Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62) (p62)
Gene: SQSTM1

Interactor 2: HDAC6 (Q9UBN7)
Protein deacetylase HDAC6 (EC 3.5.1.-) (E3 ubiquitin-protein ligase HDAC6) (EC 2.3.2.-) (Tubulin-lysine deacetylase HDAC6) (EC 3.5.1.-)
Gene: HDAC6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	0.60	0.721

The method score is based on:

Property	Details
Experiments	26363065, 30469013, 32082291, 22674379, 24086678, 31857589
Identification Methods	affinity chromatography technology
Interaction Type	physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0008270 - zinc ion binding GO:0010821 - regulation of mitochondrion organization and 5 others more... GO:0016234 - inclusion body GO:0016235 - aggresome GO:0019899 - enzyme binding GO:0031625 - ubiquitin protein ligase binding GO:0043130 - ubiquitin binding
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1	440
Hs

1	1215

Service provided by Combinatics, Japan

Last updated: 11Aug2025