Protein: HDAC2
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-) (YY1 transcription factor-binding protein)

Gene: HDAC2
Organism: Mus musculus
Interactions: 89
UniProt ID: P70288

Gene Ontology (top 5):
GO:0000118 - histone deacetylase complex
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000792 - heterochromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

148672

HDAC1
Histone deacetylase 1

5

16

Small-scale

0.914

High

1000006

SIN3A
Paired amphipathic helix protein Sin3a

5

18

Small-scale

0.909

High

1000040

MTA2
Metastasis-associated protein MTA2

5

20

Small-scale

0.909

High

1000020

KDM1A
Lysine-specific histone demethylase 1A

4

10

Small-scale

0.683

High

629224

PO5F1
POU domain, class 5, transcription factor 1

3

3

Small-scale

0.656

High

1000023

NANOG
Homeobox protein NANOG

3

11

Small-scale

0.656

High

1000028

RCOR2
REST corepressor 2

1

20

Small-scale

0.646

High

59100

CHD5
Chromodomain-helicase-DNA-binding protein 5

1

20

Small-scale

0.618

High

1000031

MTA1
Metastasis-associated protein MTA1

1

20

Small-scale

0.618

High

1000042

MBD3
Methyl-CpG-binding domain protein 3

1

12

Small-scale

0.618

High

98275

ZN431
Zinc finger protein 431

1

1

Small-scale

0.589

High

872969

SOX2
Transcription factor SOX-2

2

20

Small-scale

0.588

High

1000037

RING2
E3 ubiquitin-protein ligase RING2

2

15

Small-scale

0.584

High

1000005

Q5DTP7
Chromodomain-helicase-DNA-binding protein 4

1

20

High-throughput

0.575

High

1000018

HDAC4
Histone deacetylase 4

1

18

Small-scale

0.575

High

1000030

RCOR1
REST corepressor 1

1

20

Small-scale

0.575

High

1000034

FOXP3
Forkhead box protein P3

2

15

Small-scale

0.571

High

915925

PDX1
Pancreas/duodenum homeobox protein 1

1

5

Small-scale

0.561

High

999993

CRY1
Cryptochrome-1

1

1

Small-scale

0.561

High

1000013

SIX3
Homeobox protein SIX3

1

3

Small-scale

0.561

High

205223

FOG1
Zinc finger protein ZFPM1

1

14

Small-scale

0.536

High

999991

TNIK
Traf2 and NCK-interacting protein kinase

1

9

High-throughput

0.536

High

1000001

TF2L1
Transcription factor CP2-like protein 1

1

4

High-throughput

0.536

High

1000004

HERC2
E3 ubiquitin-protein ligase HERC2

1

8

High-throughput

0.536

High

1000012

ERR2
Steroid hormone receptor ERR2

1

20

High-throughput

0.536

High

1000021

MYCB2
E3 ubiquitin-protein ligase MYCBP2

1

6

High-throughput

0.536

High

1000022

MBB1A
Myb-binding protein 1A

1

3

Small-scale

0.536

High

1000025

SALL4
Sal-like protein 4

1

7

High-throughput

0.536

High

266706

GFI1B
Zinc finger protein Gfi-1b

1

9

Small-scale

0.516

High

60002

ARI1A
AT-rich interactive domain-containing protein 1A

1

12

Small-scale

0.515

High

604511

SPI1
Transcription factor PU.1

1

10

Small-scale

0.515

High

980640

H4
Histone H4

1

12

Small-scale

0.501

High

1000019

Q6P5E3
Sal-like protein 1

1

8

Small-scale

0.501

High

1000038

DDX20
Probable ATP-dependent RNA helicase DDX20

1

13

Small-scale

0.501

High

536216

PARP1
Poly [ADP-ribose] polymerase 1

1

14

Small-scale

0.500

High

999997

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

20

Small-scale

0.500

High

1000032

HOP
Homeodomain-only protein

1

2

Small-scale

0.500

High

236515

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

12

Small-scale

0.484

High

1000011

Q60I23
SRY

1

20

High-throughput

0.484

High

1000016

Q6AXH7
Histone-lysine N-methyltransferase EZH2

1

20

High-throughput

0.484

High

312867

CTBP1
C-terminal-binding protein 1

1

6

High-throughput

0.481

High

1000035

HDAC9
Histone deacetylase 9

1

19

High-throughput

0.481

High

147392

S1PR1
Sphingosine 1-phosphate receptor 1

1

1

Small-scale

0.479

High

267160

SP3
Transcription factor Sp3

1

20

Small-scale

0.479

High

312636

SAP30
Histone deacetylase complex subunit SAP30

1

7

Small-scale

0.479

High

470397

IL6
Interleukin-6

1

1

Small-scale

0.479

High

482130

JUNB
Transcription factor JunB

1

14

Small-scale

0.479

High

561201

FOSB
Protein FosB

1

20

Small-scale

0.479

High

596906

ASSY
Argininosuccinate synthase

1

2

Small-scale

0.479

High

607331

GATA1
Erythroid transcription factor

1

15

Small-scale

0.479

High

644290

TAL1
T-cell acute lymphocytic leukemia protein 1 homolog

1

8

Small-scale

0.479

High

655039

CXA1
Gap junction alpha-1 protein

1

3

Small-scale

0.479

High

703228

APEX1
DNA repair nuclease/redox regulator APEX1

1

4

Small-scale

0.479

High

772546

IRS1
Insulin receptor substrate 1

1

15

Small-scale

0.479

High

834652

CD27
CD27 antigen

1

1

Small-scale

0.479

High

921233

CEBPA
CCAAT/enhancer-binding protein alpha

1

10

Small-scale

0.479

High

947424

LMBL2
Lethal(3)malignant brain tumor-like protein 2

1

10

Small-scale

0.479

High

999992

SMYD1
Histone-lysine N-methyltransferase Smyd1

1

4

Small-scale

0.479

High

999994

JDP2
Jun dimerization protein 2

1

17

Small-scale

0.479

High

999995

TYY1
Transcriptional repressor protein YY1

1

11

Small-scale

0.479

High

999996

TF65
Transcription factor p65

1

20

Small-scale

0.479

High

999998

DDB1
DNA damage-binding protein 1

1

8

Small-scale

0.479

High

999999

Q3UM65
Runt-related transcription factor

1

12

Small-scale

0.479

High

1000002

TET1
Methylcytosine dioxygenase TET1

1

4

Small-scale

0.479

High

1000003

TET2
Methylcytosine dioxygenase TET2

1

4

Small-scale

0.479

High

1000007

PRDM1
PR domain zinc finger protein 1

1

6

Small-scale

0.479

High

1000008

ATF3
Cyclic AMP-dependent transcription factor ATF-3

1

20

Small-scale

0.479

High

1000009

PML
Protein PML

1

18

Small-scale

0.479

High

1000010

RBBP7
Histone-binding protein RBBP7

1

20

Small-scale

0.479

High

1000014

TFE3
Transcription factor E3

1

9

High-throughput

0.479

High

1000015

ZBT7B
Zinc finger and BTB domain-containing protein 7B

1

19

High-throughput

0.479

High

1000024

Q8BPK8
Fragile X messenger ribonucleoprotein 1

1

10

High-throughput

0.479

High

1000026

A16L1
Autophagy-related protein 16-1

1

12

High-throughput

0.479

High

1000027

Q8C5P6
C2H2-type domain-containing protein

1

14

Small-scale

0.479

High

1000033

TF7L2
Transcription factor 7-like 2

1

20

Small-scale

0.479

High

1000036

CNTP2
Contactin-associated protein-like 2

1

3

High-throughput

0.479

High

1000039

CAF1A
Chromatin assembly factor 1 subunit A

1

7

High-throughput

0.479

High

1000041

KLF5
Krueppel-like factor 5

1

20

Small-scale

0.479

High

148244

OGG1
N-glycosylase/DNA lyase [Includes: 8-oxoguanine DNA glycosylase

1

0

Small-scale

0.458

High

441581

CD4
T-cell surface glycoprotein CD4

1

0

Small-scale

0.458

High

1000017

TEDC2
Tubulin epsilon and delta complex protein 2

1

0

High-throughput

0.458

High

204744

AN32A
Acidic leucine-rich nuclear phosphoprotein 32 family member A

1

5

Small-scale

0.457

High

777856

FMR1
Fragile X messenger ribonucleoprotein 1

1

10

High-throughput

0.445

High

883758

CENPC
Centromere protein C

1

8

High-throughput

0.445

High

999990

TBX5
T-box transcription factor TBX5

1

7

Small-scale

0.445

High

1000029

MT21E
Protein-lysine methyltransferase METTL21E

1

4

High-throughput

0.437

High

915533

HMGA2
High mobility group protein HMGI-C

1

0

High-throughput

0.426

High

378660

IL2RA
Interleukin-2 receptor subunit alpha

1

0

Small-scale

0.249

Low

1000000

LCLT1
Lysocardiolipin acyltransferase 1

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025