HitPredict

Interactor 1: HDAC1 (Q13547)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein deacylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1

Interactor 2: DNM3L (Q9UJW3)
DNA (cytosine-5)-methyltransferase 3-like
Gene: DNMT3L

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.639

The method score is based on:

Property	Details
Experiments	12177302, 12202768
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000792 - heterochromatin GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006346 - DNA methylation-dependent constitutive heterochromatin formation and 3 others more... GO:0019899 - enzyme binding GO:0045814 - negative regulation of gene expression, epigenetic GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1	482
Hs

1	386

Service provided by Combinatics, Japan

Last updated: 11Aug2025