Protein: DNM3B
DNA (cytosine-5)-methyltransferase 3B (Dnmt3b) (EC 2.1.1.37) (DNA methyltransferase HsaIIIB) (DNA MTase HsaIIIB) (M.HsaIIIB)

Gene: DNM3B, DNMT3B
Organism: Homo sapiens
Interactions: 103
UniProt ID: Q9UBC3

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003677 - DNA binding
GO:0003714 - transcription corepressor activity
GO:0003886 - DNA (cytosine-5-)-methyltransferase activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1458302

DNM3A
DNA

7

8

Small-scale

0.963

High

685080

DNMT1
DNA

7

9

Small-scale

0.961

High

1458297

DNM3L
DNA

5

8

Small-scale

0.924

High

853425

CBX5
Chromobox protein homolog 5

4

8

Small-scale

0.893

High

243756

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

2

7

Small-scale

0.799

High

1097604

CBX3
Chromobox protein homolog 3

2

8

Small-scale

0.768

High

1449043

HELLS
Lymphoid-specific helicase

1

10

Small-scale

0.724

High

1155856

EZH2
Histone-lysine N-methyltransferase EZH2

5

15

Small-scale

0.721

High

1110143

HDAC1
Histone deacetylase 1

4

7

Small-scale

0.692

High

1403665

UHRF1
E3 ubiquitin-protein ligase UHRF1

3

9

Small-scale

0.661

High

216552

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

9

Small-scale

0.647

High

998901

H31
Histone H3.1

1

8

Small-scale

0.647

High

285504

EED
Polycomb protein EED

2

5

Small-scale

0.635

High

1368174

HDAC2
Histone deacetylase 2

2

7

Small-scale

0.624

High

277840

H2AY
Core histone macro-H2A.1

1

4

High-throughput

0.618

High

317019

MTA2
Metastasis-associated protein MTA2

1

4

Small-scale

0.618

High

591869

H2AX
Histone H2AX

1

4

High-throughput

0.618

High

1014221

CBX1
Chromobox protein homolog 1

1

8

Small-scale

0.618

High

1102677

MTA1
Metastasis-associated protein MTA1

1

4

Small-scale

0.618

High

1133023

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

7

Small-scale

0.618

High

1439227

CHD8
Chromodomain-helicase-DNA-binding protein 8

1

7

Small-scale

0.618

High

874009

NRIP1
Nuclear receptor-interacting protein 1

1

1

Small-scale

0.586

High

993784

UBC9
SUMO-conjugating enzyme UBC9

1

1

Small-scale

0.581

High

1388759

SIR1
NAD-dependent protein deacetylase sirtuin-1

2

0

Small-scale

0.576

High

1458299

PCDGG
Protocadherin gamma-B4

2

2

High-throughput

0.574

High

1458298

ZHX1
Zinc fingers and homeoboxes protein 1

1

1

Small-scale

0.573

High

609940

SPI1
Transcription factor PU.1

1

2

Small-scale

0.561

High

1110912

TDG
G/T mismatch-specific thymine DNA glycosylase

1

1

Small-scale

0.561

High

1115471

CUL4B
Cullin-4B

1

6

Small-scale

0.561

High

991446

SUMO1
Small ubiquitin-related modifier 1

1

0

Small-scale

0.557

High

334116

SMC2
Structural maintenance of chromosomes protein 2

1

1

Small-scale

0.550

High

1409676

CND3
Condensin complex subunit 3

1

0

Small-scale

0.537

High

940470

TCL1A
T-cell leukemia/lymphoma protein 1A

1

1

High-throughput

0.536

High

1137562

SUZ12
Polycomb protein SUZ12

1

4

Small-scale

0.536

High

331606

KIF4A
Chromosome-associated kinesin KIF4A

1

0

Small-scale

0.527

High

1139859

SETB1
Histone-lysine N-methyltransferase SETDB1

1

18

Small-scale

0.515

High

1204401

SGO1
Shugoshin 1

1

0

High-throughput

0.513

High

657935

SYWC
Tryptophan--tRNA ligase, cytoplasmic

1

1

High-throughput

0.508

High

860994

RS10
Small ribosomal subunit protein eS10

1

1

High-throughput

0.508

High

224908

BUD23
18S rRNA

1

1

Small-scale

0.501

High

331683

MBD4
Methyl-CpG-binding domain protein 4

1

4

Small-scale

0.501

High

1157978

DDB1
DNA damage-binding protein 1

1

2

Small-scale

0.501

High

1458296

BAZ2A
Bromodomain adjacent to zinc finger domain protein 2A

1

2

Small-scale

0.501

High

1062692

DHX9
ATP-dependent RNA helicase A

1

0

High-throughput

0.493

High

1400519

CDK15
Cyclin-dependent kinase 15

1

0

High-throughput

0.493

High

274926

LRP5
Low-density lipoprotein receptor-related protein 5

1

1

High-throughput

0.489

High

287621

LRP6
Low-density lipoprotein receptor-related protein 6

1

1

High-throughput

0.489

High

1051880

EF1A2
Elongation factor 1-alpha 2

1

1

High-throughput

0.489

High

1458300

PCDA4
Protocadherin alpha-4

1

2

High-throughput

0.489

High

1152487

T22D1
TSC22 domain family protein 1

1

0

High-throughput

0.486

High

1383941

UBE2W
Ubiquitin-conjugating enzyme E2 W

1

0

High-throughput

0.486

High

1415393

DUS23
Dual specificity protein phosphatase 23

1

0

High-throughput

0.486

High

1154946

NEDD8
Ubiquitin-like protein NEDD8

1

0

Small-scale

0.480

High

166577

BACH1
Transcription regulator protein BACH1

1

3

Small-scale

0.479

High

193352

MAFG
Transcription factor MafG

1

1

Small-scale

0.479

High

208907

ZBT24
Zinc finger and BTB domain-containing protein 24

1

1

Small-scale

0.479

High

297699

PIAS1
E3 SUMO-protein ligase PIAS1

1

2

Small-scale

0.479

High

334592

ZBT7A
Zinc finger and BTB domain-containing protein 7A

1

5

Small-scale

0.479

High

508762

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

2

Small-scale

0.479

High

593234

CREB1
Cyclic AMP-responsive element-binding protein 1

1

4

Small-scale

0.479

High

621780

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

3

Small-scale

0.479

High

667494

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

2

Small-scale

0.479

High

851689

GATA4
Transcription factor GATA-4

1

2

High-throughput

0.479

High

887475

CEBPD
CCAAT/enhancer-binding protein delta

1

6

Small-scale

0.479

High

905235

MECP2
Methyl-CpG-binding protein 2

1

7

High-throughput

0.479

High

912148

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

1

Small-scale

0.479

High

1066528

RBBP4
Histone-binding protein RBBP4

1

7

Small-scale

0.479

High

1100482

TIF1B
Transcription intermediary factor 1-beta

1

1

Small-scale

0.479

High

1112753

CUL1
Cullin-1

1

6

Small-scale

0.479

High

1113008

CUL2
Cullin-2

1

6

Small-scale

0.479

High

1114530

CUL3
Cullin-3

1

6

Small-scale

0.479

High

1115113

CUL4A
Cullin-4A

1

6

Small-scale

0.479

High

1127708

HIC1
Hypermethylated in cancer 1 protein

1

2

Small-scale

0.479

High

1151977

TWST1
Twist-related protein 1

1

1

Small-scale

0.479

High

1159032

RBBP7
Histone-binding protein RBBP7

1

7

Small-scale

0.479

High

1240713

CDC73
Parafibromin

1

1

Small-scale

0.479

High

1243875

CTR9
RNA polymerase-associated protein CTR9 homolog

1

1

Small-scale

0.479

High

1250682

BCOR
BCL-6 corepressor

1

8

Small-scale

0.479

High

1286805

KAISO
Transcriptional regulator Kaiso

1

2

Small-scale

0.479

High

1330577

PAF1
RNA polymerase II-associated factor 1 homolog

1

1

Small-scale

0.479

High

1357920

LEO1
RNA polymerase-associated protein LEO1

1

1

Small-scale

0.479

High

1364044

RTF1
RNA polymerase-associated protein RTF1 homolog

1

1

Small-scale

0.479

High

1371888

CUL5
Cullin-5

1

6

Small-scale

0.479

High

1396314

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

8

Small-scale

0.479

High

1399973

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

8

Small-scale

0.479

High

1449745

ZFP57
Zinc finger protein 57 homolog

1

1

Small-scale

0.479

High

212343

SNUT1
U4/U6.U5 tri-snRNP-associated protein 1

1

0

High-throughput

0.458

High

446547

DPOLB
DNA polymerase beta

1

0

Small-scale

0.458

High

1037425

H11
Histone H1.1

1

0

Small-scale

0.458

High

1061621

FOXM1
Forkhead box protein M1

1

0

Small-scale

0.458

High

487843

PARP1
Poly [ADP-ribose] polymerase 1

1

1

Small-scale

0.445

High

1403035

SIN3A
Paired amphipathic helix protein Sin3a

1

2

Small-scale

0.445

High

1449551

SMC4
Structural maintenance of chromosomes protein 4

1

1

Small-scale

0.445

High

932039

EPHB1
Ephrin type-B receptor 1

1

1

Small-scale

0.437

High

1452804

UGGG1
UDP-glucose:glycoprotein glucosyltransferase 1

1

0

High-throughput

0.279

Low

1404315

PCY2
Ethanolamine-phosphate cytidylyltransferase

1

0

High-throughput

0.265

Low

1428400

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

0

High-throughput

0.265

Low

1451067

PKHJ1
Pleckstrin homology domain-containing family J member 1

1

0

High-throughput

0.265

Low

1451907

CKLF6
CKLF-like MARVEL transmembrane domain-containing protein 6

1

0

High-throughput

0.265

Low

1458301

TIM16
Mitochondrial import inner membrane translocase subunit TIM16

1

0

High-throughput

0.265

Low

1386729

AP2M1
AP-2 complex subunit mu

1

0

High-throughput

0.261

Low

1386518

FXRD1
FAD-dependent oxidoreductase domain-containing protein 1

1

0

High-throughput

0.249

Low

1214212

LITD1
LINE-1 type transposase domain-containing protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025