Protein: DNM3A
DNA (cytosine-5)-methyltransferase 3A (Dnmt3a) (EC 2.1.1.37) (Cysteine methyltransferase DNMT3A) (EC 2.1.1.-) (DNA methyltransferase HsaIIIA) (DNA MTase HsaIIIA) (M.HsaIIIA)

Gene: DNM3A, DNMT3A
Organism: Homo sapiens
Interactions: 92
UniProt ID: Q9Y6K1

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000775 - chromosome, centromeric region
GO:0000791 - euchromatin
GO:0000792 - heterochromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1460711

DNM3L
DNA

7

8

Small-scale

0.970

High

1458302

DNM3B
DNA

7

8

Small-scale

0.963

High

999016

H31
Histone H3.1

6

8

Small-scale

0.941

High

1403677

UHRF1
E3 ubiquitin-protein ligase UHRF1

3

9

Small-scale

0.861

High

685090

DNMT1
DNA

3

9

Small-scale

0.857

High

1017341

H33
Histone H3.3

3

8

Small-scale

0.848

High

853445

CBX5
Chromobox protein homolog 5

3

8

Small-scale

0.834

High

1405207

MPP8
M-phase phosphoprotein 8

2

6

Small-scale

0.812

High

1491848

DNM3A
DNA

2

8

Small-scale

0.792

High

981209

H2B1C
Histone H2B type 1-C/E/F/G/I

2

6

High-throughput

0.754

High

129835

CBX4
E3 SUMO-protein ligase CBX4

1

9

Small-scale

0.724

High

216573

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

9

Small-scale

0.724

High

940478

TCL1A
T-cell leukemia/lymphoma protein 1A

5

1

High-throughput

0.721

High

1110230

HDAC1
Histone deacetylase 1

3

7

Small-scale

0.664

High

1014242

CBX1
Chromobox protein homolog 1

1

8

Small-scale

0.647

High

1155958

EZH2
Histone-lysine N-methyltransferase EZH2

2

15

Small-scale

0.634

High

297721

PIAS1
E3 SUMO-protein ligase PIAS1

2

2

Small-scale

0.631

High

1405551

ZBT18
Zinc finger and BTB domain-containing protein 18

2

7

Small-scale

0.629

High

373651

MYC
Myc proto-oncogene protein

2

3

Small-scale

0.624

High

277866

H2AY
Core histone macro-H2A.1

1

4

High-throughput

0.618

High

502192

H2AZ
Histone H2A.Z

1

4

High-throughput

0.618

High

591907

H2AX
Histone H2AX

1

4

High-throughput

0.618

High

883750

CENPA
Histone H3-like centromeric protein A

1

8

High-throughput

0.618

High

1399983

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

8

Small-scale

0.618

High

1371813

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

0

Small-scale

0.614

High

874021

NRIP1
Nuclear receptor-interacting protein 1

1

1

Small-scale

0.586

High

1139888

SETB1
Histone-lysine N-methyltransferase SETDB1

1

18

Small-scale

0.586

High

1331146

ZN513
Zinc finger protein 513

2

0

High-throughput

0.580

High

1407147

MDFI
MyoD family inhibitor

2

0

High-throughput

0.580

High

297888

PIAS2
E3 SUMO-protein ligase PIAS2

1

2

Small-scale

0.573

High

993836

UBC9
SUMO-conjugating enzyme UBC9

1

1

Small-scale

0.573

High

659328

SP100
Nuclear autoantigen Sp-100

1

1

High-throughput

0.573

High

442844

RB
Retinoblastoma-associated protein

2

0

Small-scale

0.569

High

224914

BUD23
18S rRNA

1

1

Small-scale

0.561

High

414937

P53
Cellular tumor antigen p53

1

1

Small-scale

0.561

High

609944

SPI1
Transcription factor PU.1

1

2

Small-scale

0.561

High

1115499

CUL4B
Cullin-4B

1

6

Small-scale

0.561

High

1158022

DDB1
DNA damage-binding protein 1

1

1

Small-scale

0.561

High

1094516

ZBT17
Zinc finger and BTB domain-containing protein 17

2

0

Small-scale

0.559

High

285543

EED
Polycomb protein EED

1

5

Small-scale

0.554

High

162749

ANM5
Protein arginine N-methyltransferase 5

1

0

Small-scale

0.554

High

1452501

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.529

High

1144238

TEBP
Prostaglandin E synthase 3

1

1

Small-scale

0.527

High

1040654

CREM
cAMP-responsive element modulator

1

4

Small-scale

0.515

High

733235

OTX1
Homeobox protein OTX1

1

1

High-throughput

0.515

High

1232660

Q6FHY5
MEOX2 protein

1

3

High-throughput

0.515

High

1278373

COMD6
COMM domain-containing protein 6

1

0

High-throughput

0.513

High

1396338

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

8

Small-scale

0.501

High

1436934

EHMT1
Histone-lysine N-methyltransferase EHMT1

1

8

Small-scale

0.501

High

301785

WFS1
Wolframin

1

0

High-throughput

0.493

High

1462210

PCDA4
Protocadherin alpha-4

1

2

High-throughput

0.489

High

894277

MEOX2
Homeobox protein MOX-2

1

2

High-throughput

0.481

High

660903

HAP40
40-kDa huntingtin-associated protein

1

0

Small-scale

0.480

High

406859

MYCN
N-myc proto-oncogene protein

1

3

Small-scale

0.479

High

487944

PARP1
Poly [ADP-ribose] polymerase 1

1

1

High-throughput

0.479

High

613244

EGR1
Early growth response protein 1

1

3

High-throughput

0.479

High

621807

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

1

Small-scale

0.479

High

667526

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

1

Small-scale

0.479

High

851717

GATA4
Transcription factor GATA-4

1

2

High-throughput

0.479

High

887482

CEBPD
CCAAT/enhancer-binding protein delta

1

6

Small-scale

0.479

High

905354

MECP2
Methyl-CpG-binding protein 2

1

7

High-throughput

0.479

High

912163

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

1

Small-scale

0.479

High

932534

PRRX1
Paired mesoderm homeobox protein 1

1

2

Small-scale

0.479

High

1085646

FOXO1
Forkhead box protein O1

1

1

Small-scale

0.479

High

1100597

TIF1B
Transcription intermediary factor 1-beta

1

1

Small-scale

0.479

High

1110914

TDG
G/T mismatch-specific thymine DNA glycosylase

1

1

Small-scale

0.479

High

1127709

HIC1
Hypermethylated in cancer 1 protein

1

2

Small-scale

0.479

High

1236147

TET2
Methylcytosine dioxygenase TET2

1

1

Small-scale

0.479

High

1240734

CDC73
Parafibromin

1

1

Small-scale

0.479

High

1243888

CTR9
RNA polymerase-associated protein CTR9 homolog

1

1

Small-scale

0.479

High

1286811

KAISO
Transcriptional regulator Kaiso

1

2

Small-scale

0.479

High

1330585

PAF1
RNA polymerase II-associated factor 1 homolog

1

1

Small-scale

0.479

High

1357926

LEO1
RNA polymerase-associated protein LEO1

1

1

Small-scale

0.479

High

1364049

RTF1
RNA polymerase-associated protein RTF1 homolog

1

1

Small-scale

0.479

High

1449746

ZFP57
Zinc finger protein 57 homolog

1

1

Small-scale

0.479

High

1459502

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

171953

ZN263
Zinc finger protein 263

1

0

Small-scale

0.458

High

191187

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

High-throughput

0.458

High

431624

AP2A
Transcription factor AP-2-alpha

1

0

Small-scale

0.458

High

462090

HS90A
Heat shock protein HSP 90-alpha

1

0

High-throughput

0.458

High

732439

PRDX2
Peroxiredoxin-2

1

0

Small-scale

0.458

High

984042

RBX1
E3 ubiquitin-protein ligase RBX1

1

0

Small-scale

0.458

High

1028148

IRF9
Interferon regulatory factor 9

1

0

Small-scale

0.458

High

1215393

DCAF8
DDB1- and CUL4-associated factor 8

1

0

Small-scale

0.458

High

1281651

SLN11
Schlafen family member 11

1

0

High-throughput

0.458

High

1415923

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

1416673

SALL3
Sal-like protein 3

1

0

Small-scale

0.458

High

1449273

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.458

High

1459023

DAXX
Death domain-associated protein 6

1

0

Small-scale

0.458

High

1491283

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

106941

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025