HitPredict

Interactor 1: CUL1 (Q13616)
Cullin-1 (CUL-1)
Gene: CUL1

Interactor 2: CSN6 (Q7L5N1)
COP9 signalosome complex subunit 6 (SGN6) (Signalosome subunit 6) (JAB1-containing signalosome subunit 6) (MOV34 homolog) (Vpr-interacting protein) (hVIP)
Gene: COPS6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	1.00	0.960

Property	Details
Experiments	29103612, 34237211, 21145461, 22474075, 19615732, 19295130, unassigned3799
Identification Methods	affinity chromatography technology, tandem affinity purification, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cullin_Nedd8~JAB
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 776 Hs			1 327
+	Hs
		1114915 CUL4A_HUMAN (7-776): 0: 778: 30.41		CSN6_HUMAN (1-327): 1.81e-141: 404: 100.00
+	Hs
		1115271 CUL4B_HUMAN (7-776): 0: 771: 29.90		CSN6_HUMAN (1-327): 1.81e-141: 404: 100.00
+	Hs
		95846 CUL4B_HUMAN (7-776): 0: 771: 29.90		E7EM64_HUMAN (1-327): 1.08e-139: 399: 99.69
+	Hs
		1113512 CUL3_HUMAN (9-776): 0: 746: 30.47		CSN6_HUMAN (1-327): 1.81e-141: 404: 100.00
+	Hs
		1112891 CUL2_HUMAN (13-776): 0: 718: 35.98		CSN6_HUMAN (1-327): 1.81e-141: 404: 100.00
+	Hs
		131421 CUL3_HUMAN (9-776): 0: 746: 30.47		EIF3F_HUMAN (10-306): 1.15e-110: 327: 22.07
+	Hs
		906515 CUL3_HUMAN (9-776): 0: 746: 30.47		PSMD7_HUMAN (37-317): 1.49e-97: 292: 24.48
+	Hs
		1272514 CUL5_HUMAN (2-776): 0: 620: 28.85		CSN6_HUMAN (1-327): 1.81e-141: 404: 100.00
+	Hs
		187963 CUL4A_HUMAN (7-776): 0: 778: 30.41		EIF3H_HUMAN (33-305): 9.06e-59: 194: 14.38
+	Ce
		1018841 CUL3_CAEEL (10-776): 0: 667: 27.06		CSN5_CAEEL (29-253): 1.44e-51: 176: 11.95