HitPredict

Interactor 1: GRM5 (Q3UVX5)
Metabotropic glutamate receptor 5 (mGluR5)
Gene: GRM5

Interactor 2: HOME2 (Q9QWW1)
Homer protein homolog 2 (Homer-2) (Cupidin) (VASP/Ena-related gene up-regulated during seizure and LTP 2) (Vesl-2)
Gene: Homer2

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	9808458
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0007216 - G protein-coupled glutamate receptor signaling pathway GO:0030425 - dendrite GO:0098978 - glutamatergic synapse
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 1203 Mm			1 354
+	Mm
		1113353 GRM5_MOUSE (15-1203): 0: 1086: 100.00		HOME1_MOUSE (1-350): 5.59e-49: 170: 50.55
+	Rn
		680341 GRM5_RAT (15-1203): 0: 1087: 98.99		HOME1_RAT (1-350): 3.1e-48: 168: 50.55
+	Hs
		783783 GRM5_HUMAN (15-1203): 0: 1028: 93.99		HOME1_HUMAN (1-350): 2.35e-52: 178: 50.86
+	Rn
		292329 GRM1_RAT (2-1203): 0: 930: 58.34		HOME2_RAT (1-354): 1.18e-55: 187: 98.59
+	Mm
		956897 GRM1_MOUSE (2-1203): 0: 924: 58.35		HOME2_MOUSE (1-354): 7.07e-56: 187: 100.00
+	Hs
		1029211 GRM1_HUMAN (3-1203): 0: 927: 58.52		HOME1_HUMAN (1-350): 2.35e-52: 178: 50.86
+	Rn
		616098 GRM1_RAT (2-1203): 0: 930: 58.34		HOME1_RAT (1-350): 3.1e-48: 168: 50.55
+	Rn
		616099 GRM1_RAT (2-1203): 0: 930: 58.34		HOME3_RAT (3-350): 3.71e-48: 167: 45.43
+	Mm
		956898 GRM1_MOUSE (2-1203): 0: 924: 58.35		HOME1_MOUSE (1-350): 5.59e-49: 170: 50.55
+	Rn
		936851 GRM8_RAT (4-850): 0: 843: 40.81		ROCK2_RAT (20-346): 1.02e-27: 116: 12.13
+	Dm
		115347 GRM_DROME (1-931): 0: 812: 35.74		M9PEX1_DROME (1-350): 1.59e-28: 116: 30.00
+	Hs
		148808 GRM2_HUMAN (17-840): 0: 783: 43.40		CTRO_HUMAN (19-352): 3.61e-16: 82: 14.25