HitPredict

Interactor 1: FBW1A (Q3ULA2)
F-box/WD repeat-containing protein 1A (Beta-TrCP protein E3RS-IkappaB) (Beta-transducin repeat-containing protein) (Beta-TrCP) (E3RSIkappaB) (mE3RS-IkappaB) (F-box and WD repeats protein beta-TrCP) (HOS) (Ubiquitin ligase FWD1) (pIkappaB-E3 receptor subunit)
Gene: Btrc

Interactor 2: CUL1 (Q9WTX6)
Cullin-1 (CUL-1)
Gene: CUL1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.830

Property	Details
Experiments	10097128, 11735228, 23452855
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cullin~F-box-like
Common GO terms	GO:0006511 - ubiquitin-dependent protein catabolic process GO:0016567 - protein ubiquitination GO:0019005 - SCF ubiquitin ligase complex GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process GO:0070936 - protein K48-linked ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 605 Mm			1 776
+	Hs
		1041292 FBW1A_HUMAN (1-605): 0: 585: 98.68		CUL1_HUMAN (1-776): 0: 911: 99.87
+	Hs
		1043319 FBW1A_HUMAN (1-605): 0: 585: 98.68		CUL4A_HUMAN (7-776): 0: 783: 30.41
+	Hs
		1041266 FBW1B_HUMAN (110-605): 3.55e-147: 437: 87.30		CUL1_HUMAN (1-776): 0: 911: 99.87
+	Hs
		1043297 FBW1B_HUMAN (110-605): 3.55e-147: 437: 87.30		CUL4A_HUMAN (7-776): 0: 783: 30.41
+	Hs
		1043637 FBW1B_HUMAN (110-605): 3.55e-147: 437: 87.30		CUL4B_HUMAN (7-776): 0: 774: 29.90
+	Hs
		1274084 FBW1A_HUMAN (1-605): 0: 585: 98.68		CUL5_HUMAN (2-776): 0: 622: 28.98
+	Mm
		1257398 FBXW7_MOUSE (409-603): 3.53e-53: 195: 31.63		CUL1_MOUSE (1-776): 0: 912: 100.00
+	Hs
		1041133 FBXW7_HUMAN (409-603): 5.92e-53: 194: 31.63		CUL1_HUMAN (1-776): 0: 911: 99.87
+	Hs
		903206 WDR5_HUMAN (458-605): 7.01e-38: 144: 25.33		CUL1_HUMAN (1-776): 0: 911: 99.87
+	Sp
		142905 POP2_SCHPO (35-603): 5.81e-99: 318: 19.38		CUL1_SCHPO (1-776): 0: 733: 41.04
+	Hs
		1041272 FBXW2_HUMAN (459-591): 3.56e-26: 113: 25.71		CUL1_HUMAN (1-776): 0: 911: 99.87
+	Hs
		792982 LIS1_HUMAN (124-494): 8.72e-70: 233: 19.13		CUL4A_HUMAN (7-776): 0: 783: 30.41
+	Hs
		1043085 WDR5B_HUMAN (160-491): 5.58e-64: 215: 18.39		CUL4A_HUMAN (7-776): 0: 783: 30.41
+	Hs
		1043441 WDR5B_HUMAN (160-491): 5.58e-64: 215: 18.39		CUL4B_HUMAN (7-776): 0: 774: 29.90
+	Hs
		1043499 FBXW7_HUMAN (409-603): 5.92e-53: 194: 31.63		CUL4B_HUMAN (7-776): 0: 774: 29.90
+	Sp
		142916 POP1_SCHPO (64-522): 7.79e-53: 195: 16.60		CUL1_SCHPO (1-776): 0: 733: 41.04
+	Hs
		903208 WDR5_HUMAN (458-605): 7.01e-38: 144: 25.33		CUL4A_HUMAN (7-776): 0: 783: 30.41
+	Hs
		903209 WDR5_HUMAN (458-605): 7.01e-38: 144: 25.33		CUL4B_HUMAN (7-776): 0: 774: 29.90
+	Hs
		903207 WDR5_HUMAN (458-605): 7.01e-38: 144: 25.33		CUL3_HUMAN (9-776): 0: 749: 30.47
+	Sp
		142915 POF1_SCHPO (59-431): 6.76e-34: 138: 15.43		CUL1_SCHPO (1-776): 0: 733: 41.04