HitPredict

Interactor 1: CUL4A (Q13619)
Cullin-4A (CUL-4A)
Gene: CUL4A

Interactor 2: DCNL1 (Q96GG9)
DCN1-like protein 1 (DCNL1) (DCUN1 domain-containing protein 1) (Defective in cullin neddylation protein 1-like protein 1) (Squamous cell carcinoma-related oncogene)
Gene: DCUN1D1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	1.00	0.968

Property	Details
Experiments	31973889, 21145461, 23201271, 26906416, 30587576, 19617556, 18826954
Identification Methods	affinity chromatography technology, enzymatic study, pull down, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Cullin_Nedd8~Cullin_binding
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 759 Hs			1 259
+	Hs
		1114898 CUL4A_HUMAN (1-759): 0: 958: 100.00		DCNL2_HUMAN (1-257): 3.47e-130: 370: 78.21
+	Hs
		1115358 CUL4B_HUMAN (10-759): 0: 922: 82.31		DCNL1_HUMAN (1-259): 3.36e-134: 380: 100.00
+	Hs
		1115254 CUL4B_HUMAN (10-759): 0: 922: 82.31		DCNL2_HUMAN (1-257): 3.47e-130: 370: 78.21
+	Hs
		1114969 CUL4A_HUMAN (1-759): 0: 958: 100.00		DCNL4_HUMAN (42-250): 9.79e-90: 269: 31.10
+	Hs
		1114927 CUL4A_HUMAN (1-759): 0: 958: 100.00		DCNL3_HUMAN (54-250): 7.9e-85: 257: 41.58
+	Hs
		1115036 CUL4A_HUMAN (1-759): 0: 958: 100.00		DCNL5_HUMAN (55-248): 1.36e-85: 256: 34.02
+	Hs
		1115330 CUL4B_HUMAN (10-759): 0: 922: 82.31		DCNL4_HUMAN (42-250): 9.79e-90: 269: 31.10
+	Hs
		1113983 CUL3_HUMAN (32-759): 0: 810: 38.23		DCNL1_HUMAN (1-259): 3.36e-134: 380: 100.00
+	Hs
		1113434 CUL3_HUMAN (32-759): 0: 810: 38.23		DCNL2_HUMAN (1-257): 3.47e-130: 370: 78.21
+	Hs
		1115287 CUL4B_HUMAN (10-759): 0: 922: 82.31		DCNL3_HUMAN (54-250): 7.9e-85: 257: 41.58
+	Hs
		1115393 CUL4B_HUMAN (10-759): 0: 922: 82.31		DCNL5_HUMAN (55-248): 1.36e-85: 256: 34.02
+	Hs
		1112655 CUL1_HUMAN (59-759): 0: 740: 30.55		DCNL1_HUMAN (1-259): 3.36e-134: 380: 100.00
+	Dm
		1202995 Q5BI50_DROME (27-759): 0: 872: 65.90		DCNL3_DROME (37-250): 4.93e-79: 243: 35.95
+	Hs
		1112556 CUL1_HUMAN (59-759): 0: 740: 30.55		DCNL2_HUMAN (1-257): 3.47e-130: 370: 78.21
+	Hs
		1113872 CUL3_HUMAN (32-759): 0: 810: 38.23		DCNL4_HUMAN (42-250): 9.79e-90: 269: 31.10
+	Hs
		1113623 CUL3_HUMAN (32-759): 0: 810: 38.23		DCNL3_HUMAN (54-250): 7.9e-85: 257: 41.58
+	Hs
		1114161 CUL3_HUMAN (32-759): 0: 810: 38.23		DCNL5_HUMAN (55-248): 1.36e-85: 256: 34.02
+	Hs
		1112632 CUL1_HUMAN (59-759): 0: 740: 30.55		DCNL4_HUMAN (42-250): 9.79e-90: 269: 31.10
+	Hs
		1112587 CUL1_HUMAN (59-759): 0: 740: 30.55		DCNL3_HUMAN (54-250): 7.9e-85: 257: 41.58
+	Hs
		1112694 CUL1_HUMAN (59-759): 0: 740: 30.55		DCNL5_HUMAN (55-248): 1.36e-85: 256: 34.02