HitPredict

Interactor 1: CRY2 (Q49AN0)
Cryptochrome-2
Gene: CRY2

Interactor 2: FBXL3 (Q9UKT7)
F-box/LRR-repeat protein 3 (F-box and leucine-rich repeat protein 3A) (F-box/LRR-repeat protein 3A)
Gene: FBXL3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	0.60	0.751

Property	Details
Experiments	25756610, 31155351, 33961781, 17463251, 27529127, 32937135, 24085301
Identification Methods	affinity chromatography technology, pull down, two hybrid, enzymatic study, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0042752 - regulation of circadian rhythm GO:0043153 - entrainment of circadian clock by photoperiod
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 593 Hs			1 428
+	Mm
		1207952 CRY2_MOUSE (18-593): 0: 810: 96.01		FBXL3_MOUSE (1-428): 0: 821: 97.20
+	Mm
		1206353 CRY2_MOUSE (18-593): 0: 810: 96.01		FXL21_MOUSE (19-428): 0: 721: 75.18
+	Mm
		956905 CRY1_MOUSE (21-524): 0: 677: 80.16		FBXL3_MOUSE (1-428): 0: 821: 97.20
+	Hs
		1082163 CRY1_HUMAN (21-524): 0: 678: 80.75		FBXL3_HUMAN (1-428): 0: 819: 100.00
+	Hs
		1115766 CRY2_HUMAN (18-593): 0: 781: 100.00		FXL21_HUMAN (16-428): 0: 713: 72.73
+	Mm
		956903 CRY1_MOUSE (21-524): 0: 677: 80.16		FXL21_MOUSE (19-428): 0: 721: 75.18
+	Hs
		1082162 CRY1_HUMAN (21-524): 0: 678: 80.75		FXL21_HUMAN (16-428): 0: 713: 72.73