Protein: HIPK2
Homeodomain-interacting protein kinase 2 (hHIPk2) (EC 2.7.11.1)

Gene: HIPK2
Organism: Homo sapiens
Interactions: 91
UniProt ID: Q9H2X6

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001654 - eye development
GO:0003016 - respiratory system process
GO:0003713 - transcription coactivator activity
GO:0003714 - transcription corepressor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1432267

HIPK2
Homeodomain-interacting protein kinase 2

6

16

Small-scale

0.936

High

181174

AXIN1
Axin-1

3

3

Small-scale

0.827

High

1201058

ACTBL
Beta-actin-like protein 2

2

8

High-throughput

0.789

High

214032

M3K7
Mitogen-activated protein kinase kinase kinase 7

2

20

Small-scale

0.777

High

414605

P53
Cellular tumor antigen p53

12

14

Small-scale

0.760

High

1432275

ZBTB4
Zinc finger and BTB domain-containing protein 4

1

3

Small-scale

0.756

High

362375

ABL1
Tyrosine-protein kinase ABL1

1

20

Small-scale

0.747

High

1307794

SIAH1
E3 ubiquitin-protein ligase SIAH1

5

13

Small-scale

0.732

High

993743

UBC9
SUMO-conjugating enzyme UBC9

5

14

Small-scale

0.719

High

714419

PML
Protein PML

4

20

Small-scale

0.694

High

1098844

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

20

Small-scale

0.691

High

1028390

MDM2
E3 ubiquitin-protein ligase Mdm2

3

8

Small-scale

0.681

High

964738

DCAF7
DDB1- and CUL4-associated factor 7

3

19

Small-scale

0.680

High

1432276

NLK
Serine/threonine-protein kinase NLK

1

18

Small-scale

0.680

High

1432278

DAXX
Death domain-associated protein 6

3

3

Small-scale

0.664

High

991425

SUMO1
Small ubiquitin-related modifier 1

3

8

Small-scale

0.661

High

1067711

EP300
Histone acetyltransferase p300

2

20

Small-scale

0.650

High

412600

NTRK1
High affinity nerve growth factor receptor

1

20

Small-scale

0.647

High

519421

MYB
Transcriptional activator Myb

2

20

Small-scale

0.636

High

211597

SIAH2
E3 ubiquitin-protein ligase SIAH2

2

17

Small-scale

0.634

High

227666

SPOP
Speckle-type POZ protein

2

7

Small-scale

0.634

High

1414067

MKNK1
MAP kinase-interacting serine/threonine-protein kinase 1

1

20

High-throughput

0.621

High

1116010

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

17

Small-scale

0.618

High

1432282

DYR1B
Dual specificity tyrosine-phosphorylation-regulated kinase 1B

1

20

Small-scale

0.618

High

1029942

RUNX1
Runt-related transcription factor 1

1

3

Small-scale

0.609

High

905137

MECP2
Methyl-CpG-binding protein 2

1

8

Small-scale

0.578

High

1163202

H2B2E
Histone H2B type 2-E

1

17

Small-scale

0.578

High

1388730

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

17

Small-scale

0.578

High

1432268

P63
Tumor protein 63

2

14

Small-scale

0.576

High

1411294

LZTS2
Leucine zipper putative tumor suppressor 2

2

20

High-throughput

0.574

High

487744

PARP1
Poly [ADP-ribose] polymerase 1

1

14

Small-scale

0.561

High

555425

SKI
Ski oncogene

1

5

Small-scale

0.561

High

685345

PAX6
Paired box protein Pax-6

1

8

Small-scale

0.561

High

1097554

CBX3
Chromobox protein homolog 3

1

4

Small-scale

0.561

High

1154007

SMAD1
Mothers against decapentaplegic homolog 1

1

18

Small-scale

0.561

High

1156208

ZYX
Zyxin

1

15

Small-scale

0.561

High

1139133

DAZP2
DAZ-associated protein 2

1

0

Small-scale

0.554

High

1402298

RANB9
Ran-binding protein 9

1

16

Small-scale

0.552

High

1432283

WSB1
WD repeat and SOCS box-containing protein 1

1

18

Small-scale

0.542

High

1382490

T53I1
Tumor protein p53-inducible nuclear protein 1

1

0

Small-scale

0.537

High

1432273

AATF
Protein AATF

1

0

Small-scale

0.537

High

1116586

FHL3
Four and a half LIM domains protein 3

1

15

High-throughput

0.536

High

1123110

FHL2
Four and a half LIM domains protein 2

1

15

High-throughput

0.536

High

1384203

RGMA
Repulsive guidance molecule A

1

1

High-throughput

0.536

High

1047863

TLE1
Transducin-like enhancer protein 1

1

17

Small-scale

0.527

High

1275970

SETX
Probable helicase senataxin

1

6

Small-scale

0.508

High

1432269

CHM4B
Charged multivesicular body protein 4b

1

4

High-throughput

0.508

High

388089

MBP
Myelin basic protein

1

1

Small-scale

0.501

High

519454

MYBA
Myb-related protein A

1

20

Small-scale

0.501

High

939227

SUMO3
Small ubiquitin-related modifier 3

1

8

Small-scale

0.501

High

964454

SUMO2
Small ubiquitin-related modifier 2

1

8

Small-scale

0.501

High

1014614

SMAD3
Mothers against decapentaplegic homolog 3

1

18

Small-scale

0.501

High

1153906

SMAD2
Mothers against decapentaplegic homolog 2

1

18

Small-scale

0.501

High

1432274

SENP1
Sentrin-specific protease 1

1

2

Small-scale

0.501

High

1055035

MEF2C
Myocyte-specific enhancer factor 2C

1

7

Small-scale

0.500

High

186804

P73
Tumor protein p73

1

14

Small-scale

0.481

High

731607

STIP1
Stress-induced-phosphoprotein 1

1

12

Small-scale

0.481

High

851812

NKX21
Homeobox protein Nkx-2.1

1

6

Small-scale

0.481

High

129804

CBX4
E3 SUMO-protein ligase CBX4

1

4

Small-scale

0.479

High

179741

MDM4
Protein Mdm4

1

8

Small-scale

0.479

High

219751

FOXO3
Forkhead box protein O3

1

13

Small-scale

0.479

High

325107

HEXI1
Protein HEXIM1

1

6

High-throughput

0.479

High

519564

MYBB
Myb-related protein B

1

20

Small-scale

0.479

High

520369

ANDR
Androgen receptor

1

20

High-throughput

0.479

High

540948

ERG
Transcriptional regulator ERG

1

2

High-throughput

0.479

High

659300

SP100
Nuclear autoantigen Sp-100

1

19

Small-scale

0.479

High

941552

CTBP2
C-terminal-binding protein 2

1

13

High-throughput

0.479

High

1090913

TRAF2
TNF receptor-associated factor 2

1

15

Small-scale

0.479

High

1103369

CTBP1
C-terminal-binding protein 1

1

13

High-throughput

0.479

High

1109387

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

4

Small-scale

0.479

High

1112710

CUL1
Cullin-1

1

16

Small-scale

0.479

High

1232907

XAF1
XIAP-associated factor 1

1

2

Small-scale

0.479

High

1357556

DCAF4
DDB1- and CUL4-associated factor 4

1

1

High-throughput

0.479

High

1368481

CBP
CREB-binding protein

1

19

Small-scale

0.479

High

1371434

DVL3
Segment polarity protein dishevelled homolog DVL-3

1

20

Small-scale

0.479

High

1380158

FBXW7
F-box/WD repeat-containing protein 7

1

18

Small-scale

0.479

High

1432270

SMUF2
E3 ubiquitin-protein ligase SMURF2

1

20

Small-scale

0.479

High

1432271

SENP2
Sentrin-specific protease 2

1

2

Small-scale

0.479

High

1432277

ZMYM2
Zinc finger MYM-type protein 2

1

1

High-throughput

0.479

High

1432279

FBX3
F-box only protein 3

1

1

Small-scale

0.479

High

1432280

CHIP
E3 ubiquitin-protein ligase CHIP

1

10

Small-scale

0.479

High

1432281

FBW1A
F-box/WD repeat-containing protein 1A

1

18

Small-scale

0.479

High

1150567

TRADD
Tumor necrosis factor receptor type 1-associated DEATH domain protein

1

0

Small-scale

0.458

High

1339882

KNL1
Outer kinetochore KNL1 complex subunit KNL1

1

0

High-throughput

0.458

High

1118160

DX39B
Spliceosome RNA helicase DDX39B

1

18

Small-scale

0.457

High

601852

HMGA1
High mobility group protein HMG-I/HMG-Y

1

2

Small-scale

0.445

High

1395026

SPTCS
Spatacsin

1

0

Small-scale

0.438

High

1399136

CF418
Cilia- and flagella-associated protein 418

1

0

Small-scale

0.438

High

1432272

DISC1
Disrupted in schizophrenia 1 protein

1

2

High-throughput

0.417

High

480504

GROA
Growth-regulated alpha protein

1

0

Small-scale

0.292

High


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Last updated: 11Aug2025