HitPredict

Interactor 1: LARP7 (Q4G0J3)
La-related protein 7 (La ribonucleoprotein domain family member 7) (hLARP7) (P-TEFb-interaction protein for 7SK stability) (PIP7S)
Gene: LARP7

Interactor 2: CDK12 (Q9NYV4)
Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12)
Gene: CDK12

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	29845934
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006397 - mRNA processing GO:0008380 - RNA splicing
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 582 Hs			1 1490
+	Hs
		1047603 LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00		CDK13_HUMAN (305-1490): 2.21e-167: 545: 41.39
+	Hs
		625477 LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00		CDK2_HUMAN (724-1026): 4.65e-140: 433: 41.12
+	Hs
		960098 LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00		CDK3_HUMAN (724-1028): 3.61e-139: 431: 42.48
+	Hs
		414946 LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00		CDK1_HUMAN (724-1025): 9.75e-134: 416: 39.15
+	Hs
		841759 LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00		CDK9_HUMAN (724-1079): 1.45e-124: 394: 42.90
+	Hs
		960291 LARP7_HUMAN (1-582): 1.26e-127: 388: 100.00		CDK5_HUMAN (724-1026): 1.2e-121: 383: 39.15
+	Mm
		985653 LARP7_MOUSE (8-582): 1.3e-120: 370: 79.20		CDK9_MOUSE (724-1079): 1.88e-124: 394: 43.72
+	Hs
		403088 LA_HUMAN (24-365): 5.96e-44: 163: 18.83		CDK2_HUMAN (724-1026): 4.65e-140: 433: 41.12
+	Hs
		516362 PABP1_HUMAN (1-405): 1.94e-40: 157: 10.29		CDK2_HUMAN (724-1026): 4.65e-140: 433: 41.12
+	At
		1103363 LRP1A_ARATH (10-367): 4.77e-56: 204: 16.85		CKB12_ARATH (724-1028): 7.95e-121: 382: 36.62
+	Hs
		516422 PABP1_HUMAN (1-405): 1.94e-40: 157: 10.29		CDK9_HUMAN (724-1079): 1.45e-124: 394: 42.90
+	Hs
		841792 LARP4_HUMAN (22-216): 3.23e-40: 157: 21.32		CDK9_HUMAN (724-1079): 1.45e-124: 394: 42.90
+	Mm
		857304 TIA1_MOUSE (120-325): 5.06e-24: 106: 13.94		MK01_MOUSE (713-1052): 1.32e-134: 421: 32.65
+	Hs
		414931 ELAV1_HUMAN (92-211): 7.72e-13: 71.9: 22.50		CDK1_HUMAN (724-1025): 9.75e-134: 416: 39.15
+	Hs
		841782 LARP1_HUMAN (29-114): 6.35e-13: 73.8: 40.23		CDK9_HUMAN (724-1079): 1.45e-124: 394: 42.90
+	Sc
		376920 PABP_YEAST (9-243): 8.44e-33: 134: 13.47		CTK1_YEAST (733-1056): 2.54e-73: 256: 45.73