Protein: PKHF2
Pleckstrin homology domain-containing family F member 2 (PH domain-containing family F member 2) (Endoplasmic reticulum-associated apoptosis-involved protein containing PH and FYVE domains) (EAPF) (PH and FYVE domain-containing protein 2) (Phafin-2) (Phafin2) (Zinc finger FYVE domain-containing protein 18)

Gene: PKHF2, PLEKHF2
Organism: Homo sapiens
Interactions: 179
UniProt ID: Q9H8W4

Gene Ontology (top 5):
GO:0005769 - early endosome
GO:0005783 - endoplasmic reticulum
GO:0007032 - endosome organization
GO:0008270 - zinc ion binding
GO:0008333 - endosome to lysosome transport

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

291030

ADAP1
Arf-GAP with dual PH domain-containing protein 1

2

3

High-throughput

0.783

High

1038357

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

2

2

High-throughput

0.783

High

1228889

ZFY26
Zinc finger FYVE domain-containing protein 26

2

13

High-throughput

0.783

High

1436621

DP13A
DCC-interacting protein 13-alpha

1

1

High-throughput

0.723

High

902252

RAB28
Ras-related protein Rab-28

2

8

High-throughput

0.700

High

933897

GEM
GTP-binding protein GEM

2

8

High-throughput

0.700

High

1396045

SCYL1
N-terminal kinase-like protein

2

2

High-throughput

0.700

High

1436610

PK1IP
p21-activated protein kinase-interacting protein 1

2

8

High-throughput

0.700

High

1395250

LMBL3
Lethal(3)malignant brain tumor-like protein 3

3

2

High-throughput

0.675

High

1381283

FBXW5
F-box/WD repeat-containing protein 5

2

0

High-throughput

0.655

High

585103

ZN250
Zinc finger protein 250

2

3

High-throughput

0.633

High

1436626

TRAF6
TNF receptor-associated factor 6

2

12

High-throughput

0.633

High

1286238

NPM2
Nucleoplasmin-2

3

5

High-throughput

0.616

High

1419485

FRMD8
FERM domain-containing protein 8

3

4

High-throughput

0.616

High

1436630

SETBP
SET-binding protein

3

1

High-throughput

0.616

High

343810

LDOC1
Protein LDOC1

3

1

High-throughput

0.613

High

959657

MAX
Protein max

3

4

High-throughput

0.609

High

1436064

UBE2Z
Ubiquitin-conjugating enzyme E2 Z

3

2

High-throughput

0.609

High

355600

NSD2
Histone-lysine N-methyltransferase NSD2

2

6

High-throughput

0.606

High

520635

RARA
Retinoic acid receptor alpha

2

8

High-throughput

0.606

High

675684

TYY1
Transcriptional repressor protein YY1

2

6

High-throughput

0.606

High

892422

ZN165
Zinc finger protein 165

2

3

High-throughput

0.606

High

992533

RS21
Small ribosomal subunit protein eS21

2

1

High-throughput

0.606

High

1081306

RGF1B
Ras-GEF domain-containing family member 1B

2

3

High-throughput

0.606

High

1156076

ZBTB6
Zinc finger and BTB domain-containing protein 6

2

4

High-throughput

0.606

High

1249654

ZDH24
Probable palmitoyltransferase ZDHHC24

2

1

High-throughput

0.606

High

1315294

TRI22
E3 ubiquitin-protein ligase TRIM22

2

9

High-throughput

0.606

High

1336732

ZN439
Zinc finger protein 439

2

5

High-throughput

0.606

High

1436614

ZN581
Zinc finger protein 581

2

5

High-throughput

0.606

High

1436623

BL1S6
Biogenesis of lysosome-related organelles complex 1 subunit 6

2

0

High-throughput

0.601

High

2935

A0A0C4DGQ7
EMAP like 2

1

3

High-throughput

0.594

High

1053279

Q05BL1
TP53BP2 protein

1

13

High-throughput

0.594

High

1097744

STK3
Serine/threonine-protein kinase 3

1

3

High-throughput

0.594

High

1206594

RAB41
Ras-related protein Rab-41

1

19

High-throughput

0.594

High

335293

TFIP8
Tumor necrosis factor alpha-induced protein 8

2

2

High-throughput

0.584

High

531150

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

2

2

High-throughput

0.584

High

1436620

PRAF1
Prenylated Rab acceptor protein 1

2

1

High-throughput

0.584

High

1436622

CHIC2
Cysteine-rich hydrophobic domain-containing protein 2

2

1

High-throughput

0.584

High

1436616

HSPB7
Heat shock protein beta-7

2

1

High-throughput

0.583

High

50067

ANO9
Anoctamin-9

2

0

High-throughput

0.580

High

325600

YIF1A
Protein YIF1A

2

0

High-throughput

0.580

High

1086109

ASPH
Aspartyl/asparaginyl beta-hydroxylase

2

0

High-throughput

0.580

High

1313051

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

2

0

High-throughput

0.580

High

1429788

XRN2
5'-3' exoribonuclease 2

2

0

High-throughput

0.580

High

1435208

BCAS3
BCAS3 microtubule associated cell migration factor

2

0

High-throughput

0.580

High

1436615

THA10
THAP domain-containing protein 10

2

0

High-throughput

0.580

High

1393109

ACY3
N-acyl-aromatic-L-amino acid amidohydrolase

2

1

High-throughput

0.573

High

1289309

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

4

High-throughput

0.573

High

1350528

ZN398
Zinc finger protein 398

1

5

High-throughput

0.573

High

1405480

S10AD
Protein S100-A13

1

6

High-throughput

0.573

High

1115613

ASPP2
Apoptosis-stimulating of p53 protein 2

1

12

High-throughput

0.555

High

223471

RGS10
Regulator of G-protein signaling 10

2

3

High-throughput

0.553

High

298081

SPF27
Pre-mRNA-splicing factor SPF27

2

1

High-throughput

0.553

High

637738

FLNA
Filamin-A

2

12

High-throughput

0.553

High

684030

PTN3
Tyrosine-protein phosphatase non-receptor type 3

2

5

High-throughput

0.553

High

855286

XCR1
Chemokine XC receptor 1

2

4

High-throughput

0.553

High

930366

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

2

2

High-throughput

0.553

High

945545

RGS8
Regulator of G-protein signaling 8

2

3

High-throughput

0.553

High

948726

KR10A
Keratin-associated protein 10-10

2

1

High-throughput

0.553

High

1088026

NFIA
Nuclear factor 1 A-type

2

2

High-throughput

0.553

High

1095056

DUS4
Dual specificity protein phosphatase 4

2

2

High-throughput

0.553

High

1139135

DAZP2
DAZ-associated protein 2

2

2

High-throughput

0.553

High

1158762

U1SBP
U11/U12 small nuclear ribonucleoprotein 35 kDa protein

2

5

High-throughput

0.553

High

1165352

SYT16
Synaptotagmin-16

2

3

High-throughput

0.553

High

1195602

ARI4B
AT-rich interactive domain-containing protein 4B

2

6

High-throughput

0.553

High

1197712

MIDN
Midnolin

2

1

High-throughput

0.553

High

1208766

TBCEL
Tubulin-specific chaperone cofactor E-like protein

2

3

High-throughput

0.553

High

1233851

GRAM4
GRAM domain-containing protein 4

2

1

High-throughput

0.553

High

1235879

KRA54
Keratin-associated protein 5-4

2

1

High-throughput

0.553

High

1239744

PPR18
Phostensin

2

3

High-throughput

0.553

High

1288692

MAGI2
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2

2

5

High-throughput

0.553

High

1293328

DAA11
Dynein axonemal assembly factor 11

2

12

High-throughput

0.553

High

1314915

CC146
Coiled-coil domain-containing protein 146

2

18

High-throughput

0.553

High

1316244

DOCK3
Dedicator of cytokinesis protein 3

2

3

High-throughput

0.553

High

1328127

TTC9C
Tetratricopeptide repeat protein 9C

2

4

High-throughput

0.553

High

1331104

TEANC
Transcription elongation factor A N-terminal and central domain-containing protein

2

1

High-throughput

0.553

High

1349979

CERK1
Ceramide kinase

2

2

High-throughput

0.553

High

1358429

TP8L1
Tumor necrosis factor alpha-induced protein 8-like protein 1

2

2

High-throughput

0.553

High

1364880

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

2

10

High-throughput

0.553

High

1365436

DOCK2
Dedicator of cytokinesis protein 2

2

3

High-throughput

0.553

High

1370539

FGF13
Fibroblast growth factor 13

2

2

High-throughput

0.553

High

1398772

PWP2A
PWWP domain-containing protein 2A

2

3

High-throughput

0.553

High

1399259

SAM11
Sterile alpha motif domain-containing protein 11

2

2

High-throughput

0.553

High

1405356

P2RX7
P2X purinoceptor 7

2

1

High-throughput

0.553

High

1414137

SPON2
Spondin-2

2

1

High-throughput

0.553

High

1416455

GTPB2
GTP-binding protein 2

2

5

High-throughput

0.553

High

1417652

PACN1
Protein kinase C and casein kinase substrate in neurons protein 1

2

2

High-throughput

0.553

High

1436603

CBX8
Chromobox protein homolog 8

2

5

High-throughput

0.553

High

1436604

BRD7
Bromodomain-containing protein 7

2

4

High-throughput

0.553

High

1436607

RPRM
Protein reprimo

2

1

High-throughput

0.553

High

1436613

BARH2
BarH-like 2 homeobox protein

2

2

High-throughput

0.553

High

1436624

INO80
Chromatin-remodeling ATPase INO80

2

4

High-throughput

0.553

High

1436625

EXOC7
Exocyst complex component 7

2

1

High-throughput

0.553

High

221760

TPPC3
Trafficking protein particle complex subunit 3

1

0

High-throughput

0.549

High

171926

ZN263
Zinc finger protein 263

1

8

High-throughput

0.541

High

329013

RTN3
Reticulon-3

1

5

High-throughput

0.541

High

578721

GLNA
Glutamine synthetase

1

1

High-throughput

0.541

High

1163616

RTN1
Reticulon-1

1

5

High-throughput

0.541

High

1436605

RTN4
Reticulon-4

1

5

High-throughput

0.541

High

657045

S10A1
Protein S100-A1

1

6

High-throughput

0.523

High

1121199

SEPT6
Septin-6

1

6

High-throughput

0.523

High

1137014

SEPT2
Septin-2

1

6

High-throughput

0.523

High

1250144

RSPO2
R-spondin-2

1

7

High-throughput

0.523

High

1292623

GPBP1
Vasculin

1

1

High-throughput

0.523

High

423196

A4
Amyloid-beta precursor protein

1

5

High-throughput

0.501

High

346747

CAVN2
Caveolae-associated protein 2

1

2

High-throughput

0.494

High

730895

1433S
14-3-3 protein sigma

1

20

High-throughput

0.494

High

1127987

KPRA
Phosphoribosyl pyrophosphate synthase-associated protein 1

1

1

High-throughput

0.494

High

1144475

NONO
Non-POU domain-containing octamer-binding protein

1

3

High-throughput

0.494

High

1436602

GPBL1
Vasculin-like protein 1

1

1

High-throughput

0.494

High

1341025

THOC2
THO complex subunit 2

1

15

High-throughput

0.489

High

1384658

AIDA
Axin interactor, dorsalization-associated protein

1

0

High-throughput

0.486

High

1116589

FHL3
Four and a half LIM domains protein 3

1

3

High-throughput

0.481

High

1429047

PRD14
PR domain zinc finger protein 14

1

5

High-throughput

0.481

High

1436619

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

60759

A2RU80
MAGUK p55 subfamily member 4

1

5

High-throughput

0.470

High

1385729

Q96C98
FHL3 protein

1

4

High-throughput

0.470

High

648379

USF1
Upstream stimulatory factor 1

1

4

High-throughput

0.464

High

1133359

NC2A
Dr1-associated corepressor

1

2

High-throughput

0.464

High

1406707

SEPT5
Septin-5

1

6

High-throughput

0.464

High

178513

TBX3
T-box transcription factor TBX3

1

4

High-throughput

0.439

High

348915

EMAL2
Echinoderm microtubule-associated protein-like 2

1

5

High-throughput

0.439

High

510110

GG12I
G antigen 12I

1

1

High-throughput

0.439

High

1196249

GAG2E
G antigen 2E

1

1

High-throughput

0.439

High

1294631

NUTM1
NUT family member 1

1

2

High-throughput

0.439

High

1394860

MPP4
MAGUK p55 subfamily member 4

1

5

High-throughput

0.439

High

1436608

MBIP1
MAP3K12-binding inhibitory protein 1

3

0

High-throughput

0.358

High

1436609

FBX28
F-box only protein 28

3

0

High-throughput

0.352

High

1436627

SPEF1
Sperm flagellar protein 1

3

0

High-throughput

0.348

High

1436601

EAF6
Chromatin modification-related protein MEAF6

2

0

High-throughput

0.339

High

216308

KCAB3
Voltage-gated potassium channel subunit beta-3

2

0

High-throughput

0.316

High

225170

TRIA1
TP53-regulated inhibitor of apoptosis 1

2

0

High-throughput

0.316

High

369919

CO3
Complement C3

2

0

High-throughput

0.316

High

388090

MBP
Myelin basic protein

2

0

High-throughput

0.316

High

437472

CRBA1
Beta-crystallin A3 [Cleaved into: Beta-crystallin A3, isoform A1, Delta4 form; Beta-crystallin A3, isoform A1, Delta7 form; Beta-crystallin A3, isoform A1, Delta8 form]

2

0

High-throughput

0.316

High

528515

COX5B
Cytochrome c oxidase subunit 5B, mitochondrial

2

0

High-throughput

0.316

High

599521

FAAA
Fumarylacetoacetase

2

0

High-throughput

0.316

High

897129

AP4A
Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]

2

0

High-throughput

0.316

High

935632

MFAP1
Microfibrillar-associated protein 1

2

0

High-throughput

0.316

High

1160958

PDK4
[Pyruvate dehydrogenase

2

0

High-throughput

0.316

High

1162247

NDUA5
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5

2

0

High-throughput

0.316

High

1164205

UGPA
UTP--glucose-1-phosphate uridylyltransferase

2

0

High-throughput

0.316

High

1292081

SPA24
Spermatogenesis-associated protein 24

2

0

High-throughput

0.316

High

1292649

CCD25
Coiled-coil domain-containing protein 25

2

0

High-throughput

0.316

High

1294646

CD20B
Cell division cycle protein 20 homolog B

2

0

High-throughput

0.316

High

1328720

TR1L1
Translocating chain-associated membrane protein 1-like 1

2

0

High-throughput

0.316

High

1347769

KC5S1
Uncharacterized protein KCNJ5-AS1

2

0

High-throughput

0.316

High

1383616

RPE
Ribulose-phosphate 3-epimerase

2

0

High-throughput

0.316

High

1385800

COAC
Phosphopantothenoylcysteine decarboxylase

2

0

High-throughput

0.316

High

1390680

STALP
AMSH-like protease

2

0

High-throughput

0.316

High

1394241

BOD1
Biorientation of chromosomes in cell division protein 1

2

0

High-throughput

0.316

High

1405768

EIF3C
Eukaryotic translation initiation factor 3 subunit C

2

0

High-throughput

0.316

High

1410450

SOST
Sclerostin

2

0

High-throughput

0.316

High

1413986

MMTA2
Multiple myeloma tumor-associated protein 2

2

0

High-throughput

0.316

High

1414828

MTNA
Methylthioribose-1-phosphate isomerase

2

0

High-throughput

0.316

High

1430853

ABCG4
ATP-binding cassette sub-family G member 4

2

0

High-throughput

0.316

High

1436606

DMRT3
Doublesex- and mab-3-related transcription factor 3

2

0

High-throughput

0.316

High

1436611

THG1
Probable tRNA(His) guanylyltransferase

2

0

High-throughput

0.316

High

1436617

S14L4
SEC14-like protein 4

2

0

High-throughput

0.316

High

1436628

HEBP2
Heme-binding protein 2

2

0

High-throughput

0.316

High

1436629

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

2

0

High-throughput

0.316

High

938676

ALR
FAD-linked sulfhydryl oxidase ALR

1

0

High-throughput

0.299

High

1096637

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.299

High

1391511

BSCL2
Seipin

1

0

High-throughput

0.299

High

1421212

CEP44
Centrosomal protein of 44 kDa

1

0

High-throughput

0.299

High

1436612

TXN4B
Thioredoxin-like protein 4B

1

0

High-throughput

0.299

High

751343

DUT
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial

1

0

High-throughput

0.292

High

1330686

BEND7
BEN domain-containing protein 7

1

0

High-throughput

0.292

High

1131934

GNMT
Glycine N-methyltransferase

1

0

High-throughput

0.282

High

1154594

CC85B
Coiled-coil domain-containing protein 85B

1

0

High-throughput

0.282

High

1405414

T22D3
TSC22 domain family protein 3

1

0

High-throughput

0.282

High

608353

EGLN
Endoglin

1

0

High-throughput

0.279

Low

185113

TELT
Telethonin

1

0

High-throughput

0.268

Low

1201677

KHDC3
KH domain-containing protein 3

1

0

High-throughput

0.268

Low

505681

CC172
Coiled-coil domain-containing protein 172

1

0

High-throughput

0.265

Low

1237845

RADX
RPA-related protein RADX

1

0

High-throughput

0.265

Low

1271227

DPPA4
Developmental pluripotency-associated protein 4

1

0

High-throughput

0.265

Low

1436618

CGBP1
CGG triplet repeat-binding protein 1

1

0

High-throughput

0.265

Low

1331337

AL14E
ARL14 effector protein

1

0

High-throughput

0.251

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025