HitPredict

Interactor 1: KLH12 (Q53G59)
Kelch-like protein 12 (CUL3-interacting protein 1) (DKIR homolog) (hDKIR)
Gene: KLHL12

Interactor 2: KLH17 (Q6TDP4)
Kelch-like protein 17 (Actinfilin)
Gene: KLHL17

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.80	0.514

Property	Details
Experiments	30190310
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	BACK~BTB, BTB~BTB, Kelch_1~Kelch_1
Common GO terms	-
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 568 Hs			1 642
+	Mm
		1164599 KLH17_MOUSE (11-566): 1.56e-162: 479: 40.75		KLH17_MOUSE (1-642): 0: 543: 97.04
+	Hs
		1120764 KLH12_HUMAN (1-568): 2.43e-180: 522: 100.00		KLH12_HUMAN (72-625): 1.67e-169: 497: 40.40
+	Hs
		1120822 KLH12_HUMAN (1-568): 2.43e-180: 522: 100.00		KLH13_HUMAN (55-641): 4.61e-155: 463: 28.36
+	Hs
		1120786 KLH12_HUMAN (1-568): 2.43e-180: 522: 100.00		Q8N4I8_HUMAN (74-335): 2.15e-95: 297: 53.23
+	Hs
		1120830 KLH12_HUMAN (1-568): 2.43e-180: 522: 100.00		KLH20_HUMAN (417-641): 3.51e-66: 230: 43.61
+	Hs
		1377320 KLH20_HUMAN (2-566): 1.23e-174: 509: 43.94		KLH20_HUMAN (417-641): 3.51e-66: 230: 43.61
+	Dm
		1374538 KLHDB_DROME (3-566): 3.83e-171: 500: 42.23		KLHDB_DROME (435-641): 2.68e-64: 225: 46.64
+	Hs
		1120826 KLH12_HUMAN (1-568): 2.43e-180: 522: 100.00		KLHL3_HUMAN (438-640): 1.32e-55: 200: 40.00
+	Hs
		307182 KLH12_HUMAN (1-568): 2.43e-180: 522: 100.00		KLHL2_HUMAN (417-640): 7.4e-53: 193: 36.73
+	Hs
		1120821 KLH12_HUMAN (1-568): 2.43e-180: 522: 100.00		KLHL9_HUMAN (438-640): 1.02e-48: 181: 26.67
+	Hs
		1120833 KLH12_HUMAN (1-568): 2.43e-180: 522: 100.00		IPP_HUMAN (482-642): 3.42e-37: 148: 30.18
+	Hs
		1049221 KLH12_HUMAN (1-568): 2.43e-180: 522: 100.00		KEAP1_HUMAN (470-641): 1.48e-35: 144: 31.25
+	Hs
		1120769 KLH12_HUMAN (1-568): 2.43e-180: 522: 100.00		KLH24_HUMAN (447-642): 9.5e-33: 135: 24.62
+	Hs
		1377325 KLH20_HUMAN (2-566): 1.23e-174: 509: 43.94		IPP_HUMAN (482-642): 3.42e-37: 148: 30.18
+	Hs
		1164636 KLH20_HUMAN (2-566): 1.23e-174: 509: 43.94		KLH24_HUMAN (447-642): 9.5e-33: 135: 24.62
+	Hs
		1377330 KLH20_HUMAN (2-566): 1.23e-174: 509: 43.94		NS1BP_HUMAN (320-517): 2.29e-29: 125: 35.00
+	Dm
		980055 KELC_DROME (9-567): 1.41e-157: 489: 40.04		KELC_DROME (531-641): 7.64e-24: 109: 29.73
+	Hs
		1120827 KLH12_HUMAN (1-568): 2.43e-180: 522: 100.00		KLH21_HUMAN (350-516): 3.43e-11: 68.2: 29.55
+	Hs
		1356007 KLH20_HUMAN (2-566): 1.23e-174: 509: 43.94		KLH21_HUMAN (350-516): 3.43e-11: 68.2: 29.55