HitPredict

Interactor 1: KLH12 (Q53G59)
Kelch-like protein 12 (CUL3-interacting protein 1) (DKIR homolog) (hDKIR)
Gene: KLHL12

Interactor 2: FXL17 (Q9UF56)
F-box/LRR-repeat protein 17 (F-box and leucine-rich repeat protein 17) (F-box only protein 13)
Gene: FBXL17

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.91	1.00	0.957

Property	Details
Experiments	30190310, 31560077, 32814905, 35869491, 27716508, 35120648
Identification Methods	affinity chromatography technology, pull down, enzymatic study, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	BTB~LRR_6
Common GO terms	GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 568 Hs			1 701
+	Hs
		1354642 KLH20_HUMAN (2-566): 1.23e-174: 509: 43.94		FXL17_HUMAN (1-701): 6.07e-166: 494: 100.00
+	Hs
		1164601 KLH17_HUMAN (11-566): 1.87e-162: 479: 40.40		FXL17_HUMAN (1-701): 6.07e-166: 494: 100.00
+	Hs
		1049349 KEAP1_HUMAN (8-564): 2.73e-161: 475: 35.88		FXL17_HUMAN (1-701): 6.07e-166: 494: 100.00
+	Hs
		307226 KLHL2_HUMAN (13-567): 3.8e-158: 466: 41.36		FXL17_HUMAN (1-701): 6.07e-166: 494: 100.00
+	Hs
		1221252 KLHL7_HUMAN (19-563): 2.02e-155: 459: 32.19		FXL17_HUMAN (1-701): 6.07e-166: 494: 100.00
+	Hs
		1348054 KLH28_HUMAN (15-565): 1.89e-155: 458: 37.77		FXL17_HUMAN (1-701): 6.07e-166: 494: 100.00
+	Hs
		1350481 KLH13_HUMAN (380-568): 2.64e-43: 165: 28.06		FXL17_HUMAN (1-701): 6.07e-166: 494: 100.00
+	Hs
		1350369 KLHL9_HUMAN (380-568): 3.91e-43: 164: 27.55		FXL17_HUMAN (1-701): 6.07e-166: 494: 100.00
+	Hs
		1354637 KLHL3_HUMAN (422-568): 1.81e-34: 139: 36.05		FXL17_HUMAN (1-701): 6.07e-166: 494: 100.00
+	Hs
		1153798 KLH10_HUMAN (428-568): 1.65e-33: 136: 33.80		FXL17_HUMAN (1-701): 6.07e-166: 494: 100.00
+	Hs
		1354646 IPP_HUMAN (425-567): 7.83e-33: 134: 33.78		FXL17_HUMAN (1-701): 6.07e-166: 494: 100.00
+	Hs
		152501 ENC1_HUMAN (378-568): 9.99e-32: 131: 21.29		FXL17_HUMAN (1-701): 6.07e-166: 494: 100.00
+	Hs
		1121505 KLH26_HUMAN (365-568): 5.54e-30: 126: 23.26		FXL17_HUMAN (1-701): 6.07e-166: 494: 100.00
+	Hs
		1164633 KLH24_HUMAN (394-568): 1.15e-28: 122: 29.67		FXL17_HUMAN (1-701): 6.07e-166: 494: 100.00
+	Hs
		1327770 KLH25_HUMAN (471-567): 4.6e-11: 67.5: 16.33		FXL17_HUMAN (1-701): 6.07e-166: 494: 100.00
+	Hs
		1354639 KLH21_HUMAN (427-553): 2.26e-10: 65.5: 35.39		FXL17_HUMAN (1-701): 6.07e-166: 494: 100.00