HitPredict

Interactor 1: KLH22 (Q53GT1)
Kelch-like protein 22
Gene: KLHL22

Interactor 2: CSN5 (Q92905)
COP9 signalosome complex subunit 5 (SGN5) (Signalosome subunit 5) (EC 3.4.-.-) (Jun activation domain-binding protein 1)
Gene: COPS5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.621

Property	Details
Experiments	19615732, 21145461
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 634 Hs			1 334
+	Hs
		1120793 KLH12_HUMAN (30-594): 7.74e-153: 454: 25.18		CSN5_HUMAN (1-334): 6.64e-131: 378: 100.00
+	Hs
		1272543 KLH15_HUMAN (29-603): 8.9e-82: 271: 30.54		CSN5_HUMAN (1-334): 6.64e-131: 378: 100.00
+	Hs
		1272661 KLHL8_HUMAN (446-633): 3.96e-39: 154: 19.05		CSN5_HUMAN (1-334): 6.64e-131: 378: 100.00
+	Hs
		1153787 KLH10_HUMAN (448-633): 1.27e-38: 153: 18.18		CSN5_HUMAN (1-334): 6.64e-131: 378: 100.00
+	Hs
		299528 KLH18_HUMAN (474-634): 1.53e-31: 131: 16.67		CSN5_HUMAN (1-334): 6.64e-131: 378: 100.00
+	Hs
		1121485 KLH26_HUMAN (378-633): 3.87e-23: 106: 16.30		CSN5_HUMAN (1-334): 6.64e-131: 378: 100.00
+	Hs
		1239682 KLH23_HUMAN (494-631): 3.21e-23: 106: 23.74		CSN5_HUMAN (1-334): 6.64e-131: 378: 100.00
+	Hs
		1164621 KLH24_HUMAN (269-446): 1.01e-16: 85.7: 20.11		CSN5_HUMAN (1-334): 6.64e-131: 378: 100.00
+	Hs
		1272662 KLHL9_HUMAN (546-633): 4.32e-10: 64.9: 12.50		CSN5_HUMAN (1-334): 6.64e-131: 378: 100.00
+	Hs
		1272664 KLH13_HUMAN (546-633): 8.97e-10: 63.7: 12.50		CSN5_HUMAN (1-334): 6.64e-131: 378: 100.00
+	Hs
		1233686 KLH36_HUMAN (543-633): 3.85e-09: 61.8: 13.04		CSN5_HUMAN (1-334): 6.64e-131: 378: 100.00
+	Hs
		131121 IPP_HUMAN (445-632): 9.93e-39: 152: 16.84		PSDE_HUMAN (50-331): 1.67e-79: 246: 31.51