HitPredict

Interactor 1: PYDC2 (Q56P42)
Pyrin domain-containing protein 2 (Pyrin-only protein 2) (cellular POP2) (cPOP2)
Gene: PYDC2

Interactor 2: NLRP1 (Q9C000)
NACHT, LRR and PYD domains-containing protein 1 (EC 3.4.-.-) (EC 3.6.4.-) (Caspase recruitment domain-containing protein 7) (Death effector filament-forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain) [Cleaved into: NACHT, LRR and PYD domains-containing protein 1, C-terminus (NLRP1-CT); NACHT, LRR and PYD domains-containing protein 1, N-terminus (NLRP1-NT)]
Gene: NLRP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	17178784
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PYRIN~PYRIN
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005730 - nucleolus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 97 Hs			1 1473
+	Mm
		1246896 NLRP3_MOUSE (6-91): 9.3e-30: 112: 23.26		NLRP3_MOUSE (199-1105): 0: 646: 30.52
+	Hs
		1299023 NLRP3_HUMAN (3-91): 1.7e-29: 111: 22.47		NLRP3_HUMAN (199-1102): 0: 634: 31.19
+	Hs
		1122746 PYDC2_HUMAN (1-97): 1.23e-34: 115: 100.00		NALP2_HUMAN (142-1098): 2.1e-176: 557: 25.34
+	Hs
		1263222 NALP2_HUMAN (1-91): 7.16e-28: 107: 67.03		NALP7_HUMAN (207-1106): 1.02e-165: 526: 25.18
+	Hs
		886442 NALP5_HUMAN (6-91): 9.09e-26: 101: 27.91		NALP7_HUMAN (207-1106): 1.02e-165: 526: 25.18
+	Hs
		1299048 NLRP3_HUMAN (3-91): 1.7e-29: 111: 22.47		CARD8_HUMAN (1049-1462): 3.91e-137: 434: 42.21
+	Hs
		1202833 NAL10_HUMAN (1-93): 1.05e-26: 103: 19.36		NAL10_HUMAN (208-728): 3.96e-119: 390: 30.44
+	Hs
		1202832 NAL14_HUMAN (7-91): 1.59e-29: 112: 30.59		NAL14_HUMAN (711-1098): 1.9e-52: 204: 21.31
+	Hs
		886444 NLRP3_HUMAN (3-91): 1.7e-29: 111: 22.47		NALP5_HUMAN (576-1110): 3.01e-52: 203: 19.11
+	Hs
		886448 NALP2_HUMAN (1-91): 7.16e-28: 107: 67.03		NALP5_HUMAN (576-1110): 3.01e-52: 203: 19.11
+	Hs
		1122747 PYDC2_HUMAN (1-97): 1.23e-34: 115: 100.00		ASC_HUMAN (1353-1459): 1.19e-42: 156: 50.00
+	Hs
		1299043 NLRP3_HUMAN (3-91): 1.7e-29: 111: 22.47		ASC_HUMAN (1353-1459): 1.19e-42: 156: 50.00
+	Hs
		1122744 PYDC2_HUMAN (1-97): 1.23e-34: 115: 100.00		NALP4_HUMAN (625-983): 1.2e-35: 149: 23.83
+	Hs
		1347596 NALP2_HUMAN (1-91): 7.16e-28: 107: 67.03		ASC_HUMAN (1353-1459): 1.19e-42: 156: 50.00
+	Hs
		1202839 NAL10_HUMAN (1-93): 1.05e-26: 103: 19.36		ASC_HUMAN (1353-1459): 1.19e-42: 156: 50.00
+	Mm
		1246900 NLRP3_MOUSE (6-91): 9.3e-30: 112: 23.26		ASC_MOUSE (1380-1461): 2.2e-36: 138: 59.76
+	Hs
		1297962 NALP4_HUMAN (1-91): 1.42e-36: 132: 31.87		NLRC4_HUMAN (675-1029): 6.26e-21: 102: 17.53
+	Hs
		1299032 NLRP3_HUMAN (3-91): 1.7e-29: 111: 22.47		NLRC4_HUMAN (675-1029): 6.26e-21: 102: 17.53
+	Hs
		1299030 NLRP3_HUMAN (3-91): 1.7e-29: 111: 22.47		NOD2_HUMAN (898-1136): 4.02e-13: 76.7: 14.80
+	Hs
		886408 PYDC2_HUMAN (1-97): 1.23e-34: 115: 100.00		NAL12_HUMAN (917-1185): 4.71e-10: 66.7: 15.49