HitPredict

Interactor 1: PP6R3 (Q5H9R7)
Serine/threonine-protein phosphatase 6 regulatory subunit 3 (SAPS domain family member 3) (Sporulation-induced transcript 4-associated protein SAPL)
Gene: PPP6R3

Interactor 2: PP6R1 (Q9UPN7)
Serine/threonine-protein phosphatase 6 regulatory subunit 1 (SAPS domain family member 1)
Gene: PPP6R1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	35271311, 24255178
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0019888 - protein phosphatase regulator activity GO:0019903 - protein phosphatase binding GO:0043666 - regulation of phosphoprotein phosphatase activity
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 873 Hs			1 881
+	Hs
		257184 PP6R3_HUMAN (1-873): 0: 854: 100.00		PP6R2_HUMAN (1-880): 0: 793: 40.08
+	Hs
		257236 PP6R2_HUMAN (1-870): 0: 766: 45.79		PP6R1_HUMAN (1-881): 0: 828: 100.00
+	Zm
		111693 K7TSJ7_MAIZE (1-812): 0: 655: 23.08		K7TSJ7_MAIZE (1-791): 0: 687: 23.44
+	Sc
		777295 SA185_YEAST (366-735): 1.84e-48: 188: 15.05		SA185_YEAST (377-774): 3.41e-56: 212: 14.32
+	Dm
		113976 M9PB30_DROME (544-872): 1.33e-09: 64.5: 10.27		M9PB30_DROME (592-880): 8.55e-09: 61.9: 10.54
+	Mm
		1351630 PCLO_MOUSE (528-871): 1.98e-09: 63.8: 8.40		PCLO_MOUSE (639-870): 5.03e-09: 62.6: 14.22