Protein: PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial (PCCase subunit alpha) (EC 6.4.1.3) (Propanoyl-CoA:carbon dioxide ligase subunit alpha)

Gene: PCCA
Organism: Homo sapiens
Interactions: 120
UniProt ID: P05165

Gene Ontology (top 5):
GO:0004485 - methylcrotonoyl-CoA carboxylase activity
GO:0004658 - propionyl-CoA carboxylase activity
GO:0004847 - urea carboxylase activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

398215

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

4

18

Small-scale

0.909

High

398261

ACSM5
Acyl-coenzyme A synthetase ACSM5, mitochondrial

2

1

High-throughput

0.628

High

398294

TTC1
Tetratricopeptide repeat protein 1

2

6

High-throughput

0.628

High

398219

PYC
Pyruvate carboxylase, mitochondrial

1

15

High-throughput

0.618

High

398251

ACACA
Acetyl-CoA carboxylase 1

1

16

High-throughput

0.618

High

398291

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

16

High-throughput

0.618

High

398298

MCCB
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

1

18

High-throughput

0.618

High

398259

SYRM
Probable arginine--tRNA ligase, mitochondrial

2

1

High-throughput

0.611

High

398226

CRCM
Colorectal mutant cancer protein

2

1

High-throughput

0.606

High

226252

PRKN
E3 ubiquitin-protein ligase parkin

2

12

High-throughput

0.584

High

398229

PML
Protein PML

2

8

High-throughput

0.584

High

398234

CCNF
Cyclin-F

2

5

High-throughput

0.584

High

258647

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

1

1

High-throughput

0.536

High

270903

KBL
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial

1

1

High-throughput

0.536

High

398216

IFIT1
Interferon-induced protein with tetratricopeptide repeats 1

1

4

High-throughput

0.536

High

398227

KAD4
Adenylate kinase 4, mitochondrial

1

1

High-throughput

0.536

High

398235

PLPL4
Patatin-like phospholipase domain-containing protein 4

1

1

High-throughput

0.536

High

398238

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

2

High-throughput

0.536

High

398242

YBEY
Endoribonuclease YbeY

1

2

High-throughput

0.536

High

398263

FAHD1
Oxaloacetate decarboxylase, mitochondrial

1

1

High-throughput

0.536

High

398284

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

1

2

High-throughput

0.536

High

398297

MTG2
Mitochondrial ribosome-associated GTPase 2

1

2

High-throughput

0.536

High

398304

NPS3A
Protein NipSnap homolog 3A

1

2

High-throughput

0.536

High

398307

MRM2
rRNA methyltransferase 2, mitochondrial

1

1

High-throughput

0.536

High

398313

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

2

High-throughput

0.536

High

398314

RIPK3
Receptor-interacting serine/threonine-protein kinase 3

1

5

High-throughput

0.536

High

398256

TAZ
Tafazzin

1

0

High-throughput

0.513

High

398287

NTAQ1
Protein N-terminal glutamine amidohydrolase

1

0

High-throughput

0.513

High

398289

IP6K3
Inositol hexakisphosphate kinase 3

1

0

High-throughput

0.513

High

398303

RM27
Large ribosomal subunit protein bL27m

1

0

High-throughput

0.513

High

398224

FPR1
fMet-Leu-Phe receptor

1

1

High-throughput

0.489

High

398274

PAF1
RNA polymerase II-associated factor 1 homolog

1

3

High-throughput

0.489

High

398283

TRI43
Tripartite motif-containing protein 43

1

2

High-throughput

0.489

High

398285

RT24
Small ribosomal subunit protein uS3m

1

1

High-throughput

0.489

High

398290

O52B2
Olfactory receptor 52B2

1

1

High-throughput

0.489

High

398295

LSMD1
N-alpha-acetyltransferase 38, NatC auxiliary subunit

1

1

High-throughput

0.489

High

398296

HDHD3
Haloacid dehalogenase-like hydrolase domain-containing protein 3

1

1

High-throughput

0.489

High

398277

PJA1
E3 ubiquitin-protein ligase Praja-1

1

0

Small-scale

0.480

High

116955

SGK1
Serine/threonine-protein kinase Sgk1

1

8

High-throughput

0.479

High

119081

LEG9
Galectin-9

1

6

High-throughput

0.479

High

165904

PER2
Period circadian protein homolog 2

1

4

Small-scale

0.479

High

231961

KDM1A
Lysine-specific histone demethylase 1A

1

4

High-throughput

0.479

High

296852

LTN1
E3 ubiquitin-protein ligase listerin

1

3

High-throughput

0.479

High

385912

P53
Cellular tumor antigen p53

1

5

Small-scale

0.479

High

398217

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

8

Small-scale

0.479

High

398218

HSP7C
Heat shock cognate 71 kDa protein

1

4

High-throughput

0.479

High

398220

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

398221

LEG3
Galectin-3

1

6

Small-scale

0.479

High

398222

ARF4
ADP-ribosylation factor 4

1

10

High-throughput

0.479

High

398228

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.479

High

398233

ARL1
ADP-ribosylation factor-like protein 1

1

11

High-throughput

0.479

High

398237

YAP1
Transcriptional coactivator YAP1

1

10

High-throughput

0.479

High

398243

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

6

Small-scale

0.479

High

398244

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

2

Small-scale

0.479

High

398246

RBX1
E3 ubiquitin-protein ligase RBX1

1

5

High-throughput

0.479

High

398252

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

2

High-throughput

0.479

High

398253

HDAC1
Histone deacetylase 1

1

10

High-throughput

0.479

High

398260

DCA15
DDB1- and CUL4-associated factor 15

1

4

High-throughput

0.479

High

398262

ZN746
Zinc finger protein 746

1

4

High-throughput

0.479

High

398267

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

9

High-throughput

0.479

High

398269

NAA40
N-alpha-acetyltransferase 40

1

4

High-throughput

0.479

High

398271

SMC5
Structural maintenance of chromosomes protein 5

1

6

High-throughput

0.479

High

398272

SLX4
Structure-specific endonuclease subunit SLX4

1

5

High-throughput

0.479

High

398273

WDTC1
WD and tetratricopeptide repeats protein 1

1

16

High-throughput

0.479

High

398281

FBXW5
F-box/WD repeat-containing protein 5

1

2

High-throughput

0.479

High

398282

PF21A
PHD finger protein 21A

1

5

High-throughput

0.479

High

398286

BICD1
Protein bicaudal D homolog 1

1

1

High-throughput

0.479

High

398292

RUFY1
RUN and FYVE domain-containing protein 1

1

4

High-throughput

0.479

High

398293

NECD
Necdin

1

3

High-throughput

0.479

High

398305

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

398310

DCTN4
Dynactin subunit 4

1

2

High-throughput

0.479

High

398311

RCOR1
REST corepressor 1

1

4

High-throughput

0.479

High

398316

SAR1B
Small COPII coat GTPase SAR1B

1

19

High-throughput

0.479

High

398309

ERRFI
ERBB receptor feedback inhibitor 1

1

0

Small-scale

0.460

High

398280

NALP7
NACHT, LRR and PYD domains-containing protein 7

1

0

High-throughput

0.458

High

398250

FMR1
Fragile X messenger ribonucleoprotein 1

1

1

High-throughput

0.457

High

398236

GATA4
Transcription factor GATA-4

1

1

High-throughput

0.457

High

398223

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

10

High-throughput

0.445

High

398249

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

5

High-throughput

0.445

High

398268

TLK2
Serine/threonine-protein kinase tousled-like 2

1

5

High-throughput

0.445

High

398317

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

14

High-throughput

0.445

High

225462

PCDH7
Protocadherin-7

1

2

High-throughput

0.437

High

329232

AGR2
Anterior gradient protein 2 homolog

1

4

High-throughput

0.437

High

345678

MYC
Myc proto-oncogene protein

1

6

High-throughput

0.437

High

353366

PIGR
Polymeric immunoglobulin receptor

1

4

Small-scale

0.437

High

398225

SP100
Nuclear autoantigen Sp-100

1

2

High-throughput

0.437

High

398230

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.437

High

398231

ARL3
ADP-ribosylation factor-like protein 3

1

13

High-throughput

0.437

High

398232

TRI23
E3 ubiquitin-protein ligase TRIM23

1

15

High-throughput

0.437

High

398239

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

5

High-throughput

0.437

High

398240

ARL4D
ADP-ribosylation factor-like protein 4D

1

17

High-throughput

0.437

High

398241

TSP3
Thrombospondin-3

1

1

High-throughput

0.437

High

398245

H4
Histone H4

1

4

High-throughput

0.437

High

398247

DYLT1
Dynein light chain Tctex-type 1

1

3

High-throughput

0.437

High

398248

ARF5
ADP-ribosylation factor 5

1

10

High-throughput

0.437

High

398257

ISX
Intestine-specific homeobox

1

3

High-throughput

0.437

High

398264

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.437

High

398265

UBP53
Inactive ubiquitin carboxyl-terminal hydrolase 53

1

8

Small-scale

0.437

High

398266

DET1
DET1 homolog

1

4

High-throughput

0.437

High

398270

HOOK3
Protein Hook homolog 3

1

8

High-throughput

0.437

High

398276

ARL10
ADP-ribosylation factor-like protein 10

1

17

High-throughput

0.437

High

398279

DCAF4
DDB1- and CUL4-associated factor 4

1

3

High-throughput

0.437

High

398288

ARL5B
ADP-ribosylation factor-like protein 5B

1

18

High-throughput

0.437

High

398299

SAR1A
Small COPII coat GTPase SAR1A

1

20

High-throughput

0.437

High

398301

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

3

High-throughput

0.437

High

398302

VSX1
Visual system homeobox 1

1

3

High-throughput

0.437

High

398308

HOOK1
Protein Hook homolog 1

1

8

High-throughput

0.437

High

398315

ARL5A
ADP-ribosylation factor-like protein 5A

1

19

High-throughput

0.437

High

323542

BAG2
BAG family molecular chaperone regulator 2

1

0

Small-scale

0.426

High

239242

ICMT
Protein-S-isoprenylcysteine O-methyltransferase

2

0

High-throughput

0.328

High

398312

LAMP3
Lysosome-associated membrane glycoprotein 3

2

0

High-throughput

0.328

High

64043

AQ12B
Aquaporin-12B

1

0

High-throughput

0.279

Low

398258

TBC25
TBC1 domain family member 25

1

0

High-throughput

0.279

Low

398278

FA81A
Protein FAM81A

1

0

High-throughput

0.279

Low

398300

CT096
Uncharacterized protein C20orf96

1

0

High-throughput

0.279

Low

398306

PARP2
Poly [ADP-ribose] polymerase 2

1

0

Small-scale

0.261

Low

398255

T132D
Transmembrane protein 132D

1

0

Small-scale

0.251

Low

159317

PLD2
Phospholipase D2

1

0

High-throughput

0.249

Low

398254

TRI14
Tripartite motif-containing protein 14

1

0

High-throughput

0.249

Low

398275

PLD5
Inactive phospholipase D5

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024