Interactor 1: MCM6 (Q14566)
DNA replication licensing factor MCM6 (EC 3.6.4.12) (p105MCM)
Gene: MCM6
Interactor 2: CDT1 (Q9H211)
DNA replication factor Cdt1 (Double parked homolog) (DUP)
Gene: CDT1
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.90 | 1.00 | 0.952 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 21099365, 26496610, 18162579, 18184650, 22140117, 20202939 |
| Identification Methods | pull down, affinity chromatography technology, two hybrid, x-ray crystallography, anti tag coimmunoprecipitation, nuclear magnetic resonance |
| Interaction Type | direct interaction, physical association, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | CDT1_C~MCM, CDT1_C~MCM6_C, CDT1_C~MCM_lid, CDT1~MCM_N, CDT1_C~MCM_N, CDT1_C~MCM_OB |
| Common GO terms | GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0030174 - regulation of DNA-templated DNA replication initiation |
| Homologous interactions | 7 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
