Protein: AGO4
Protein argonaute-4 (Argonaute4) (hAgo4) (Argonaute RISC catalytic component 4) (Eukaryotic translation initiation factor 2C 4) (eIF-2C 4) (eIF2C 4)

Gene: AGO4
Organism: Homo sapiens
Interactions: 123
UniProt ID: Q9HCK5

Gene Ontology (top 5):
GO:0000932 - P-body
GO:0003725 - double-stranded RNA binding
GO:0003727 - single-stranded RNA binding
GO:0004521 - RNA endonuclease activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1334275

AGO3
Protein argonaute-3

3

12

High-throughput

0.861

High

1336290

DICER
Endoribonuclease Dicer

2

20

Small-scale

0.789

High

1242663

TNR6A
Trinucleotide repeat-containing gene 6A protein

5

19

Small-scale

0.723

High

1336287

AGO2
Protein argonaute-2

1

12

High-throughput

0.691

High

1336289

TNR6B
Trinucleotide repeat-containing gene 6B protein

3

18

Small-scale

0.678

High

1336198

TNR6C
Trinucleotide repeat-containing gene 6C protein

2

20

Small-scale

0.646

High

585074

RO52
E3 ubiquitin-protein ligase TRIM21

2

3

Small-scale

0.639

High

1069522

TEBP
Prostaglandin E synthase 3

2

10

High-throughput

0.628

High

502572

BIP
Endoplasmic reticulum chaperone BiP

2

3

Small-scale

0.619

High

395820

A4
Amyloid-beta precursor protein

2

1

High-throughput

0.602

High

178277

IPO8
Importin-8

1

5

High-throughput

0.586

High

1217275

ANKY2
Ankyrin repeat and MYND domain-containing protein 2

2

6

High-throughput

0.574

High

64563

ZSWM8
Zinc finger SWIM domain-containing protein 8

1

1

High-throughput

0.536

High

153799

ANM5
Protein arginine N-methyltransferase 5

1

3

High-throughput

0.536

High

212182

HTSF1
17S U2 SnRNP complex component HTATSF1

1

14

High-throughput

0.536

High

243622

DNJA2
DnaJ homolog subfamily A member 2

1

8

High-throughput

0.536

High

397519

ADT2
ADP/ATP translocase 2

1

8

High-throughput

0.536

High

428452

TBB5
Tubulin beta chain

1

7

High-throughput

0.536

High

432278

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.536

High

432939

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

5

High-throughput

0.536

High

438545

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.536

High

504793

HSP7C
Heat shock cognate 71 kDa protein

1

6

High-throughput

0.536

High

506061

ODB2
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

1

4

High-throughput

0.536

High

574755

ARF4
ADP-ribosylation factor 4

1

1

High-throughput

0.536

High

616872

JAK1
Tyrosine-protein kinase JAK1

1

2

High-throughput

0.536

High

618719

IF4B
Eukaryotic translation initiation factor 4B

1

15

High-throughput

0.536

High

640631

DDX6
Probable ATP-dependent RNA helicase DDX6

1

20

High-throughput

0.536

High

644177

EF1G
Elongation factor 1-gamma

1

1

High-throughput

0.536

High

681611

DNJA1
DnaJ homolog subfamily A member 1

1

8

High-throughput

0.536

High

736066

ATPG
ATP synthase subunit gamma, mitochondrial

1

2

High-throughput

0.536

High

790572

RL35
Large ribosomal subunit protein uL29

1

2

High-throughput

0.536

High

805812

RL27A
Large ribosomal subunit protein uL15

1

4

High-throughput

0.536

High

807014

RS9
Small ribosomal subunit protein uS4

1

3

High-throughput

0.536

High

807242

RS5
Small ribosomal subunit protein uS7

1

4

High-throughput

0.536

High

821421

TCPE
T-complex protein 1 subunit epsilon

1

4

High-throughput

0.536

High

827605

EFTU
Elongation factor Tu, mitochondrial

1

4

High-throughput

0.536

High

839151

EMD
Emerin

1

1

High-throughput

0.536

High

858335

TXTP
Tricarboxylate transport protein, mitochondrial

1

9

High-throughput

0.536

High

892048

ACTB
Actin, cytoplasmic 1

1

2

High-throughput

0.536

High

899855

RL27
Large ribosomal subunit protein eL27

1

2

High-throughput

0.536

High

910939

RS18
Small ribosomal subunit protein uS13

1

4

High-throughput

0.536

High

919526

RL23
Large ribosomal subunit protein uL14

1

5

High-throughput

0.536

High

920701

RS26
Small ribosomal subunit protein eS26

1

2

High-throughput

0.536

High

923231

RL11
Large ribosomal subunit protein uL5

1

4

High-throughput

0.536

High

928825

RL38
Large ribosomal subunit protein eL38

1

3

High-throughput

0.536

High

931425

YBOX1
Y-box-binding protein 1

1

8

High-throughput

0.536

High

933986

TBB4B
Tubulin beta-4B chain

1

7

High-throughput

0.536

High

949567

RL24
Large ribosomal subunit protein eL24

1

3

High-throughput

0.536

High

959317

S25A3
Solute carrier family 25 member 3

1

12

High-throughput

0.536

High

989399

PRDX1
Peroxiredoxin-1

1

1

High-throughput

0.536

High

1031470

PABP4
Polyadenylate-binding protein 4

1

10

High-throughput

0.536

High

1034412

SF3B2
Splicing factor 3B subunit 2

1

2

High-throughput

0.536

High

1035009

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

16

High-throughput

0.536

High

1061626

CUL7
Cullin-7

1

3

High-throughput

0.536

High

1063288

SART3
Squamous cell carcinoma antigen recognized by T-cells 3

1

14

High-throughput

0.536

High

1075639

TRBP2
RISC-loading complex subunit TARBP2

1

15

High-throughput

0.536

High

1173881

UBP34
Ubiquitin carboxyl-terminal hydrolase 34

1

1

High-throughput

0.536

High

1219374

CUL9
Cullin-9

1

4

High-throughput

0.536

High

1237160

PAF1
RNA polymerase II-associated factor 1 homolog

1

1

High-throughput

0.536

High

1245065

KBTB8
Kelch repeat and BTB domain-containing protein 8

1

2

High-throughput

0.536

High

1261113

TRI41
E3 ubiquitin-protein ligase TRIM41

1

3

High-throughput

0.536

High

1289447

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

2

High-throughput

0.536

High

1297934

ZFP42
Zinc finger protein 42 homolog

1

2

High-throughput

0.536

High

1303434

MYCBP
c-Myc-binding protein

1

1

High-throughput

0.536

High

1308591

DHB14
17-beta-hydroxysteroid dehydrogenase 14

1

1

High-throughput

0.536

High

1309289

MEP50
Methylosome protein WDR77

1

6

High-throughput

0.536

High

1332260

STPAP
Speckle targeted PIP5K1A-regulated poly(A) polymerase

1

5

High-throughput

0.536

High

1336278

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

14

High-throughput

0.536

High

1336281

DJB11
DnaJ homolog subfamily B member 11

1

8

High-throughput

0.536

High

1336282

DIC
Mitochondrial dicarboxylate carrier

1

8

High-throughput

0.536

High

500133

CH60
60 kDa heat shock protein, mitochondrial

1

4

High-throughput

0.515

High

317768

STABP
STAM-binding protein

1

0

High-throughput

0.513

High

327711

ECD
Protein ecdysoneless homolog

1

0

High-throughput

0.513

High

506666

BCR
Breakpoint cluster region protein

1

0

High-throughput

0.513

High

847221

GALK1
Galactokinase

1

0

High-throughput

0.513

High

976190

PTPS
6-pyruvoyl tetrahydrobiopterin synthase

1

0

High-throughput

0.513

High

981436

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.513

High

1121336

AGK
Acylglycerol kinase, mitochondrial

1

0

High-throughput

0.513

High

1153146

TYW3
tRNA wybutosine-synthesizing protein 3 homolog

1

0

High-throughput

0.513

High

1261240

LEO1
RNA polymerase-associated protein LEO1

1

0

High-throughput

0.513

High

1336285

CTNA3
Catenin alpha-3

1

0

High-throughput

0.513

High

1336288

TBX20
T-box transcription factor TBX20

1

0

High-throughput

0.513

High

1160976

CTR9
RNA polymerase-associated protein CTR9 homolog

1

1

High-throughput

0.489

High

1333985

GHC1
Mitochondrial glutamate carrier 1

1

9

High-throughput

0.489

High

1336286

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

8

High-throughput

0.489

High

63212

WTIP
Wilms tumor protein 1-interacting protein

1

7

Small-scale

0.479

High

170484

TIF1A
Transcription intermediary factor 1-alpha

1

13

Small-scale

0.479

High

309081

KI20A
Kinesin-like protein KIF20A

1

9

High-throughput

0.479

High

647966

MARK3
MAP/microtubule affinity-regulating kinase 3

1

11

High-throughput

0.479

High

1066731

KIF14
Kinesin-like protein KIF14

1

6

High-throughput

0.479

High

1168845

MEX3B
RNA-binding protein MEX3B

1

6

High-throughput

0.479

High

1183128

MARK2
Serine/threonine-protein kinase MARK2

1

11

High-throughput

0.479

High

1336279

MARK1
Serine/threonine-protein kinase MARK1

1

11

High-throughput

0.479

High

1336283

LIMD1
LIM domain-containing protein 1

1

7

Small-scale

0.479

High

391914

H2A1B
Histone H2A type 1-B/E

1

2

High-throughput

0.445

High

516701

PABP1
Polyadenylate-binding protein 1

1

10

High-throughput

0.445

High

671347

RL12
Large ribosomal subunit protein uL11

1

2

High-throughput

0.445

High

882582

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

6

High-throughput

0.445

High

898495

RS3A
Small ribosomal subunit protein eS1

1

3

High-throughput

0.445

High

923542

RL8
Large ribosomal subunit protein uL2

1

2

High-throughput

0.445

High

932879

EF1A1
Elongation factor 1-alpha 1

1

3

High-throughput

0.445

High

958134

RBM10
RNA-binding protein 10

1

14

High-throughput

0.445

High

1123442

H90B4
Putative heat shock protein HSP 90-beta 4

1

20

High-throughput

0.445

High

1123506

HS905
Putative heat shock protein HSP 90-alpha A5

1

20

High-throughput

0.445

High

1175197

TBA1A
Tubulin alpha-1A chain

1

6

High-throughput

0.445

High

1301388

NUDC1
NudC domain-containing protein 1

1

1

High-throughput

0.445

High

1336277

QPCTL
Glutaminyl-peptide cyclotransferase-like protein

1

1

High-throughput

0.445

High

153389

CDIPT
CDP-diacylglycerol--inositol 3-phosphatidyltransferase

1

0

High-throughput

0.426

High

631244

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.426

High

912569

SMD2
Small nuclear ribonucleoprotein Sm D2

1

0

High-throughput

0.426

High

920562

RS25
Small ribosomal subunit protein eS25

1

0

High-throughput

0.426

High

623592

IBP6
Insulin-like growth factor-binding protein 6

1

0

High-throughput

0.279

Low

817332

LEPR
Leptin receptor

1

0

High-throughput

0.279

Low

880518

ATP5I
ATP synthase subunit e, mitochondrial

1

0

High-throughput

0.279

Low

1127416

PREP
Presequence protease, mitochondrial

1

0

High-throughput

0.279

Low

1147532

UTP25
U3 small nucleolar RNA-associated protein 25 homolog

1

0

High-throughput

0.279

Low

1157007

PR40B
Pre-mRNA-processing factor 40 homolog B

1

0

High-throughput

0.279

Low

1245846

RASF8
Ras association domain-containing protein 8

1

0

High-throughput

0.279

Low

1293820

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

1

0

High-throughput

0.279

Low

1336280

SUCB1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

1

0

High-throughput

0.279

Low

1336284

PCS1N
ProSAAS

1

0

High-throughput

0.279

Low

1336291

PPME1
Protein phosphatase methylesterase 1

1

0

High-throughput

0.279

Low

1336276

RS10L
Putative ribosomal protein eS10-like

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024