HitPredict

Interactor 1: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2

Interactor 2: FANCM (Q8IYD8)
Fanconi anemia group M protein (Protein FACM) (EC 3.6.4.13) (ATP-dependent RNA helicase FANCM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog)
Gene: FANCM

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	29513927
Identification Methods	pull down, protein array
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 2527 Hs			1 2048
+	Hs
		229420 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		SMCA5_HUMAN (4-1049): 3.79e-105: 365: 12.02
+	Hs
		2785 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		A0A0C4DGG9_HUMAN (41-1065): 1.18e-90: 331: 11.85
+	Hs
		111380 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		J3KTA4_HUMAN (13-334): 3.61e-20: 99.3: 16.10
+	Hs
		571483 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		DDX5_HUMAN (13-334): 4.25e-20: 98.9: 16.10
+	Hs
		134075 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		DDX3X_HUMAN (19-341): 3.67e-19: 96.2: 15.70
+	Hs
		2821 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		A0A0D9SF53_HUMAN (19-341): 2.23e-18: 93.9: 15.70
+	Hs
		1130627 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		DDX21_HUMAN (473-672): 2.66e-15: 84.1: 20.48
+	Hs
		1130306 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		Q8IYV2_HUMAN (70-378): 1.91e-14: 81.2: 11.91
+	Hs
		201203 M3K7_HUMAN (1869-2132): 8.36e-23: 107: 28.83		DDX5_HUMAN (13-334): 4.25e-20: 98.9: 16.10