HitPredict

Interactor 1: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2

Interactor 2: GHC1 (Q9H936)
Mitochondrial glutamate carrier 1 (GC-1) (Glutamate/H(+) symporter 1) (Solute carrier family 25 member 22)
Gene: SLC25A22

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.50	0.60	0.552

Property	Details
Experiments	unassigned1853, 24725412
Identification Methods	anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005743 - mitochondrial inner membrane
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 2527 Hs			1 323
+	Hs
		3090 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		A0A0S2Z3H3_HUMAN (97-322): 2.72e-38: 139: 19.48
+	Hs
		518152 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		ADT1_HUMAN (97-322): 2.72e-38: 139: 19.48
+	Hs
		1130213 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		Q6NVC0_HUMAN (101-322): 1.03e-37: 138: 18.50
+	Hs
		397411 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		ADT2_HUMAN (101-322): 5.12e-38: 138: 18.50
+	Hs
		858269 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		TXTP_HUMAN (5-306): 1.85e-24: 102: 27.10
+	Hs
		90255 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		D9HTE9_HUMAN (15-306): 2.48e-23: 99.8: 27.43
+	Hs
		1121048 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		Q53GR7_HUMAN (229-323): 4.85e-21: 95.7: 32.65
+	Hs
		73279 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		B4E290_HUMAN (215-313): 3.26e-17: 83.8: 17.17
+	Hs
		1123866 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		Q59EI9_HUMAN (224-322): 4.19e-13: 70.7: 25.49
+	Hs
		518382 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		ADT3_HUMAN (224-322): 3.75e-13: 70.7: 25.49
+	Hs
		397303 CSK_HUMAN (1722-2140): 2.25e-102: 339: 20.74		ADT2_HUMAN (101-322): 5.12e-38: 138: 18.50