Protein: TRXR1
Thioredoxin reductase 1, mitochondrial (EC 1.8.1.9)

Gene: TRXR1
Organism: Drosophila melanogaster
Interactions: 179
UniProt ID: P91938

Gene Ontology (top 5):
GO:0004791 - thioredoxin-disulfide reductase (NADPH) activity
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005829 - cytosol
GO:0008340 - determination of adult lifespan

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

929467

PDI
Protein disulfide-isomerase

2

8

High-throughput

0.737

High

1019628

THIO2
Thioredoxin-2

2

9

High-throughput

0.737

High

1019670

TRXR2
Thioredoxin reductase 2, mitochondrial

2

15

High-throughput

0.737

High

1019686

Q9VVL7
Dihydrolipoyl dehydrogenase

2

15

High-throughput

0.726

High

578057

ENO
Enolase

3

4

High-throughput

0.629

High

1019684

Q9VUG9
Thioredoxin-1

1

11

High-throughput

0.575

High

1019699

Q9W022
GEO01508p1

1

14

High-throughput

0.575

High

195019

O16043
Anon1A4

2

1

High-throughput

0.571

High

476923

NDKA
Nucleoside diphosphate kinase

2

1

High-throughput

0.571

High

649021

ANX10
Annexin B10

2

4

High-throughput

0.571

High

712334

CALR
Calreticulin

2

1

High-throughput

0.571

High

835130

6PGD
6-phosphogluconate dehydrogenase, decarboxylating

2

2

High-throughput

0.571

High

855984

MOEH
Moesin/ezrin/radixin homolog 1

2

1

High-throughput

0.571

High

1019583

NLP
Nucleoplasmin-like protein

2

3

High-throughput

0.571

High

1019589

Q7JX87
1-Cys peroxiredoxin

2

8

High-throughput

0.571

High

1019607

Q8STA5
Histidine triad nucleotide binding protein 1, isoform A

2

1

High-throughput

0.571

High

1019644

Q9VEB1
Malate dehydrogenase, mitochondrial

2

6

High-throughput

0.571

High

1019652

Q9VHN7
transketolase

2

4

High-throughput

0.571

High

1019676

Q9VRD6
NTF2-related export protein

2

2

High-throughput

0.571

High

1019680

Q9VSL2
Glutathione S transferase O3

2

3

High-throughput

0.571

High

1019681

Q9VTY2
Uncharacterized protein, isoform A

2

9

High-throughput

0.571

High

1019703

Q9W227
Peptidyl-prolyl cis-trans isomerase

2

1

High-throughput

0.571

High

1019597

STX4
Syntaxin-4

2

0

High-throughput

0.569

High

1019625

Q9V3V2
peptidylprolyl isomerase

2

7

High-throughput

0.521

High

1019648

Q9VGK3
peptidylprolyl isomerase

2

7

High-throughput

0.521

High

1019584

Q3YMU0
Protein disulfide-isomerase

1

6

High-throughput

0.514

High

1019614

Q95TL8
Endoplasmic reticulum protein 44, isoform A

1

9

High-throughput

0.514

High

1019629

PDIA6
Protein disulfide-isomerase A6 homolog

1

7

High-throughput

0.514

High

1019646

Q9VG33
Sulfurtransferase

1

1

High-throughput

0.514

High

1019666

Q9VMQ9
Thioredoxin domain-containing protein 17

1

0

High-throughput

0.486

High

1019610

PUF68
Poly(U)-binding-splicing factor hfp

1

2

High-throughput

0.464

High

963840

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.458

High

1019674

GOLP3
Golgi phosphoprotein 3 homolog sauron

1

0

High-throughput

0.458

High

1019693

TNG2
Transport and Golgi organization protein 2

1

0

High-throughput

0.458

High

1019581

Q0E924
Prohibitin

1

2

High-throughput

0.457

High

1019623

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

3

High-throughput

0.457

High

114333

H0RN74
FI16840p1

1

1

High-throughput

0.451

High

305555

O77434
EG:34F3.8 protein

1

1

High-throughput

0.451

High

1019604

Q8IRP2
IP07229p

1

1

High-throughput

0.451

High

53989

A1Z892
1-Cys peroxiredoxin

1

8

High-throughput

0.445

High

57536

A1ZB71
Glutathione S transferase E6

1

3

High-throughput

0.445

High

57758

A1ZB77
Uncharacterized protein, isoform J

1

2

High-throughput

0.445

High

121202

ALDR
Aldo-keto reductase 1B

1

9

High-throughput

0.445

High

197746

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

2

High-throughput

0.445

High

305644

IPYR
Inorganic pyrophosphatase

1

2

High-throughput

0.445

High

357273

O97428
Ciboulot, isoform A

1

1

High-throughput

0.445

High

357484

INO1
Inositol-3-phosphate synthase

1

1

High-throughput

0.445

High

458090

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

1

High-throughput

0.445

High

460018

ALF
Fructose-bisphosphate aldolase

1

1

High-throughput

0.445

High

556654

PSA1
Proteasome subunit alpha type-1

1

1

High-throughput

0.445

High

609375

PCNA
Proliferating cell nuclear antigen

1

1

High-throughput

0.445

High

648873

ANXB9
Annexin B9

1

4

High-throughput

0.445

High

682724

PROF
Profilin

1

3

High-throughput

0.445

High

762527

UCHL
Ubiquitin carboxyl-terminal hydrolase

1

2

High-throughput

0.445

High

821826

PSA2
Proteasome subunit alpha type-2

1

1

High-throughput

0.445

High

871607

FKB12
Peptidyl-prolyl cis-trans isomerase Fkbp12

1

7

High-throughput

0.445

High

874633

RIR2
Ribonucleoside-diphosphate reductase subunit M2

1

1

High-throughput

0.445

High

928946

DOD
Putative peptidyl-prolyl cis-trans isomerase dodo

1

2

High-throughput

0.445

High

1019577

1433E
14-3-3 protein epsilon

1

3

High-throughput

0.445

High

1019578

PGK
Phosphoglycerate kinase

1

1

High-throughput

0.445

High

1019580

ATPB
ATP synthase subunit beta, mitochondrial

1

2

High-throughput

0.445

High

1019582

Q0KHZ6
Electron transfer flavoprotein subunit beta

1

3

High-throughput

0.445

High

1019587

Q76NR6
Regucalcin

1

2

High-throughput

0.445

High

1019588

Q7JVH6
LD24696p

1

9

High-throughput

0.445

High

1019590

Q7JXC4
CG6459 protein

1

1

High-throughput

0.445

High

1019591

Q7K148
Proteasome subunit beta

1

2

High-throughput

0.445

High

1019593

TERA
Transitional endoplasmic reticulum ATPase TER94

1

5

High-throughput

0.445

High

1019594

Q7KN99
Phosphopantothenoylcysteine synthetase, isoform A

1

1

High-throughput

0.445

High

1019596

Q7KTW5
Inositol-1-monophosphatase

1

2

High-throughput

0.445

High

1019599

Q8INK3
Fatty acid-binding protein, muscle

1

1

High-throughput

0.445

High

1019601

Q8IQZ7
FI19014p1

1

6

High-throughput

0.445

High

1019602

Q8IRD3
Glutathione peroxidase

1

1

High-throughput

0.445

High

1019605

Q8MT58
Carnosine dipeptidase 2, isoform A

1

1

High-throughput

0.445

High

1019606

Q8MYY7
RE44624p

1

3

High-throughput

0.445

High

1019608

OLA1
Obg-like ATPase 1

1

2

High-throughput

0.445

High

1019609

Q8T0L3
E1 ubiquitin-activating enzyme

1

2

High-throughput

0.445

High

1019611

NACA
Nascent polypeptide-associated complex subunit alpha

1

2

High-throughput

0.445

High

1019612

ACPM
Acyl carrier protein, mitochondrial

1

3

High-throughput

0.445

High

1019613

FAXC
Failed axon connections

1

2

High-throughput

0.445

High

1019615

IF5A
Eukaryotic translation initiation factor 5A

1

1

High-throughput

0.445

High

1019616

JUPIT
Microtubule-associated protein Jupiter

1

1

High-throughput

0.445

High

1019618

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

2

High-throughput

0.445

High

1019620

SH3BG
SH3 domain-binding glutamic acid-rich protein homolog

1

1

High-throughput

0.445

High

1019624

Q9V3I1
Deoxyuridine 5'-triphosphate nucleotidohydrolase

1

1

High-throughput

0.445

High

1019630

PSA3
Proteasome subunit alpha type-3

1

4

High-throughput

0.445

High

1019633

Q9VAC1
GM14349p

1

1

High-throughput

0.445

High

1019634

Q9VAC4
GEO09167p1

1

3

High-throughput

0.445

High

1019635

Q9VAN7
Phosphoglycerate mutase

1

2

High-throughput

0.445

High

1019640

Q9VCK6
LD34157p

1

1

High-throughput

0.445

High

1019641

Q9VD02
GH14779p

1

3

High-throughput

0.445

High

1019642

Q9VD29
small monomeric GTPase

1

5

High-throughput

0.445

High

1019645

FLNA
Filamin-A

1

4

High-throughput

0.445

High

1019649

TCTP
Translationally-controlled tumor protein homolog

1

1

High-throughput

0.445

High

1019651

TEBPH
Cytosolic Prostaglandin E synthase

1

2

High-throughput

0.445

High

1019653

Q9VHX4
LD24679p

1

9

High-throughput

0.445

High

1019654

Q9VIE8
Aconitate hydratase, mitochondrial

1

1

High-throughput

0.445

High

1019657

Q9VKB0
threonine--tRNA ligase

1

3

High-throughput

0.445

High

1019658

Q9VKW5
Prolyl endopeptidase

1

1

High-throughput

0.445

High

1019659

EF1D
Probable elongation factor 1-delta

1

3

High-throughput

0.445

High

1019660

Q9VL68
Enoyl-CoA delta isomerase 1, mitochondrial

1

4

High-throughput

0.445

High

1019661

Q9VL70
HL08109p

1

1

High-throughput

0.445

High

1019662

FKB59
FK506-binding protein 59

1

5

High-throughput

0.445

High

1019663

Q9VLB7
Rab GDP dissociation inhibitor

1

1

High-throughput

0.445

High

1019664

AK200
A-kinase anchor protein 200

1

4

High-throughput

0.445

High

1019665

Q9VLS7
LD21067p

1

1

High-throughput

0.445

High

1019668

PSB4
Proteasome subunit beta type-4

1

6

High-throughput

0.445

High

1019672

Q9VPN5
Stress-induced-phosphoprotein 1

1

3

High-throughput

0.445

High

1019673

Q9VPX6
Adenylyl cyclase-associated protein

1

2

High-throughput

0.445

High

1019677

Q9VRL1
GEO06356p1

1

1

High-throughput

0.445

High

1019679

Q9VSI6
Isocitrate dehydrogenase [NADP]

1

3

High-throughput

0.445

High

1019682

Q9VU35
10 kDa heat shock protein, mitochondrial

1

1

High-throughput

0.445

High

1019683

Q9VUC1
Hsc70Cb, isoform A

1

7

High-throughput

0.445

High

1019685

Y9705
Cold shock domain-containing protein CG9705

1

1

High-throughput

0.445

High

1019687

Q9VW59
Rho GDP-dissociation inhibitor 3

1

1

High-throughput

0.445

High

1019690

DHB4
Peroxisomal multifunctional enzyme type 2

1

2

High-throughput

0.445

High

1019692

CLIC
Chloride intracellular channel Clic

1

3

High-throughput

0.445

High

1019700

Q9W0H8
Reticulocalbin-3

1

1

High-throughput

0.445

High

1019701

SND1
Staphylococcal nuclease domain-containing protein 1

1

2

High-throughput

0.445

High

1019704

Q9W3X6
fumarate hydratase

1

1

High-throughput

0.445

High

1019705

Q9W3Y3
Calcyclin-binding protein

1

3

High-throughput

0.445

High

1019706

CISY
Probable citrate synthase, mitochondrial

1

3

High-throughput

0.445

High

1019707

WUHO
tRNA

1

2

High-throughput

0.445

High

1019708

Q9W457
Serine hydroxymethyltransferase

1

2

High-throughput

0.445

High

1019710

PSB3
Proteasome subunit beta type-3

1

4

High-throughput

0.445

High

1019711

Q9XYZ9
Glutathione S transferase E12, isoform A

1

3

High-throughput

0.445

High

1019712

Q9XZ57
Eb1, isoform E

1

1

High-throughput

0.445

High

1019713

PSA6
Proteasome subunit alpha type-6

1

5

High-throughput

0.445

High

1019714

PURA
Adenylosuccinate synthetase

1

1

High-throughput

0.445

High

1019715

Q9Y112
BcDNA.GH10614

1

9

High-throughput

0.445

High

121788

M9PGI6
Secretory 22, isoform B

1

1

High-throughput

0.439

High

121905

M9PGX4
Uncharacterized protein, isoform D

1

1

High-throughput

0.439

High

1019585

Q6NP71
Lipophorin receptor 1, isoform J

1

2

High-throughput

0.439

High

1019698

Q9VZT5
GEO02591p1

1

1

High-throughput

0.439

High

120758

M9PE30
Transgelin

1

2

High-throughput

0.437

High

1019695

Q9VYR1
Regucalcin

1

2

High-throughput

0.437

High

1019598

QPCT2
Glutaminyl-peptide cyclotransferase

1

0

High-throughput

0.426

High

1019622

NIF3L
NIF3-like protein 1

1

0

High-throughput

0.426

High

1019691

Q9VXQ3
Diphosphomevalonate decarboxylase

1

0

High-throughput

0.426

High

1019694

PEPE
Probable alpha-aspartyl dipeptidase

1

0

High-throughput

0.426

High

1019631

SAM50
SAM50-like protein CG7639

1

1

High-throughput

0.417

High

1019637

Q9VBN1
Lipophorin receptor 1, isoform G

1

2

High-throughput

0.417

High

86470

B9EQV3
Endoplasmic reticulum transmembrane protein

1

1

High-throughput

0.407

High

304610

RS21
Small ribosomal subunit protein eS21

1

1

High-throughput

0.407

High

305183

TRMB
tRNA

1

1

High-throughput

0.407

High

356323

O97102
Small ubiquitin-related modifier

1

2

High-throughput

0.407

High

930117

VATE
V-type proton ATPase subunit E

1

1

High-throughput

0.407

High

1019579

HMGD
High mobility group protein D

1

1

High-throughput

0.407

High

1019592

Q7K2K2
FI04612p

1

1

High-throughput

0.407

High

1019595

Q7KTJ7
Basigin, isoform G

1

1

High-throughput

0.407

High

1019617

NASP
Nuclear autoantigenic sperm protein homolog

1

1

High-throughput

0.407

High

1019627

Q9V3V9
Endonuclease G inhibitor, isoform A

1

1

High-throughput

0.407

High

1019632

Q9V9U3
LD45254p

1

1

High-throughput

0.407

High

1019636

Q9VAY2
Heat shock protein 83

1

4

High-throughput

0.407

High

1019638

Q9VBR6
RE74917p

1

1

High-throughput

0.407

High

1019667

Q9VMU6
LD31822p

1

1

High-throughput

0.407

High

1019669

Q9VNB2
RE42193p

1

1

High-throughput

0.407

High

1019675

BACC
Bacchus

1

1

High-throughput

0.407

High

1019678

Q9VRP2
Uncharacterized protein, isoform A

1

2

High-throughput

0.407

High

1019689

RS10B
Small ribosomal subunit protein eS10B

1

1

High-throughput

0.407

High

1019697

Q9VZI1
Transgelin

1

2

High-throughput

0.407

High

1019709

Q9W478
RE43153p

1

1

High-throughput

0.407

High

1019619

Q9I7U2
GH23190p

2

0

High-throughput

0.310

High

1019643

GOSR1
Golgi SNAP receptor complex member 1

2

0

High-throughput

0.310

High

1019655

Q9VIL1
Transmembrane protein 230

2

0

High-throughput

0.310

High

1019696

Q9VZB5
MIP31077p

2

0

High-throughput

0.310

High

1019702

Q9W219
GEO12575p1

1

0

High-throughput

0.265

Low

1019647

Q9VGJ9
Heme oxygenase

1

0

High-throughput

0.249

Low

1019650

Q9VGV7
CG4570 protein

1

0

High-throughput

0.249

Low

657737

VATL
V-type proton ATPase 16 kDa proteolipid subunit c

1

0

High-throughput

0.232

Low

1019381

PEPT1
Peptide transporter family 1

1

0

High-throughput

0.232

Low

1019586

Q6QU65
ADAM metalloprotease

1

0

High-throughput

0.232

Low

1019600

Q8IPU8
BNIP3, isoform B

1

0

High-throughput

0.232

Low

1019603

Q8IRE7
PAN2-PAN3 deadenylation complex subunit PAN3

1

0

High-throughput

0.232

Low

1019621

CP2B
Cardio acceleratory peptide 2b

1

0

High-throughput

0.232

Low

1019626

SPC25
Kinetochore protein Spc25

1

0

High-throughput

0.232

Low

1019639

Q9VBT1
CHK kinase-like domain-containing protein

1

0

High-throughput

0.232

Low

1019656

Q9VIT9
TEP1-F

1

0

High-throughput

0.232

Low

1019671

Q9VP52
GH24315p

1

0

High-throughput

0.232

Low

1019688

Q9VW70
FI21813p1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025