HitPredict

Interactor 1: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2

Interactor 2: COPG2 (Q9UBF2)
Coatomer subunit gamma-2 (Gamma-2-coat protein) (Gamma-2-COP)
Gene: COPG2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.50	0.60	0.552

Property	Details
Experiments	unassigned1853, 24725412
Identification Methods	anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000139 - Golgi membrane GO:0005783 - endoplasmic reticulum GO:0005789 - endoplasmic reticulum membrane GO:0005829 - cytosol GO:0030426 - growth cone
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 2527 Hs			1 871
+	Hs
		1130787 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		COPG1_HUMAN (1-871): 0: 844: 80.44
+	Hs
		302166 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		AP2A2_HUMAN (24-871): 1.93e-180: 546: 15.30
+	Hs
		1014027 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		AP1B1_HUMAN (14-638): 2.54e-177: 538: 14.84
+	Hs
		3574 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		A0A140VJE8_HUMAN (14-600): 6.11e-176: 535: 14.45
+	Hs
		72401 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		B3KXW5_HUMAN (20-738): 4.82e-170: 516: 15.07
+	Hs
		276370 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		AP1G2_HUMAN (23-740): 4.9e-158: 483: 14.04
+	Hs
		321525 M3K9_HUMAN (1874-2136): 3.07e-24: 114: 32.38		AP2A1_HUMAN (24-871): 0: 567: 14.88
+	Hs
		302135 M3K9_HUMAN (1874-2136): 3.07e-24: 114: 32.38		AP2A2_HUMAN (24-871): 1.93e-180: 546: 15.30