HitPredict

Interactor 1: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2

Interactor 2: COR1C (Q9ULV4)
Coronin-1C (Coronin-3) (hCRNN4)
Gene: CORO1C

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	33938021
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001933 - negative regulation of protein phosphorylation GO:0007165 - signal transduction GO:0031267 - small GTPase binding
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 2527 Hs			1 474
+	Hs
		1123861 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		Q59EA2_HUMAN (1-474): 1.77e-136: 404: 100.00
+	Hs
		1130429 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		SNR40_HUMAN (160-435): 1.36e-38: 145: 11.87
+	Hs
		48975 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		A0MNP2_HUMAN (160-435): 1.36e-38: 145: 11.87
+	Hs
		1083273 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		RBBP7_HUMAN (14-341): 1.13e-35: 139: 18.94
+	Hs
		2056 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		A0A0A6YYL4_HUMAN (2-203): 1.07e-23: 106: 12.22
+	Hs
		997755 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		RBBP4_HUMAN (129-345): 4.31e-24: 106: 15.39
+	Hs
		1130792 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		WSB1_HUMAN (145-313): 6.42e-16: 81.6: 22.09
+	Hs
		903286 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		WDR5_HUMAN (257-397): 3.67e-15: 78.4: 8.39
+	Mm
		222644 LRRK2_MOUSE (1-2527): 0: 2865: 86.09		WSB1_MOUSE (145-313): 3.19e-16: 82.4: 23.84