Protein: ACSF2
Medium-chain acyl-CoA ligase ACSF2, mitochondrial (EC 6.2.1.2)

Gene: ACSF2
Organism: Homo sapiens
Interactions: 77
UniProt ID: Q96CM8

Gene Ontology (top 5):
GO:0004467 - long-chain fatty acid-CoA ligase activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0006631 - fatty acid metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1238405

ACSM5
Acyl-coenzyme A synthetase ACSM5, mitochondrial

2

9

High-throughput

0.811

High

1386074

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

5

1

High-throughput

0.657

High

1386083

IPYR2
Inorganic pyrophosphatase 2, mitochondrial

2

1

High-throughput

0.611

High

275080

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

2

2

High-throughput

0.606

High

914701

RM12
Large ribosomal subunit protein bL12m

2

0

High-throughput

0.602

High

1220526

MIC13
MICOS complex subunit MIC13

2

0

High-throughput

0.580

High

1315185

CJ067
Uncharacterized protein C10orf67, mitochondrial

2

0

High-throughput

0.580

High

1253304

DG2L6
Diacylglycerol O-acyltransferase 2-like protein 6

2

1

High-throughput

0.553

High

1351676

GP152
Probable G-protein coupled receptor 152

2

4

High-throughput

0.553

High

1386085

SENP2
Sentrin-specific protease 2

2

1

High-throughput

0.553

High

230389

CREB3
Cyclic AMP-responsive element-binding protein 3

2

2

High-throughput

0.539

High

275340

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

1

2

High-throughput

0.536

High

288247

KBL
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial

1

1

High-throughput

0.536

High

425945

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

1

High-throughput

0.536

High

532845

CH60
60 kDa heat shock protein, mitochondrial

1

5

High-throughput

0.536

High

690529

KAD4
Adenylate kinase 4, mitochondrial

1

1

High-throughput

0.536

High

842226

THIM
3-ketoacyl-CoA thiolase, mitochondrial

1

1

High-throughput

0.536

High

869208

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

2

High-throughput

0.536

High

1242606

FAHD1
Oxaloacetate tautomerase FAHD1, mitochondrial

1

1

High-throughput

0.536

High

1275808

RM21
Large ribosomal subunit protein bL21m

1

1

High-throughput

0.536

High

1386075

RT24
Small ribosomal subunit protein uS3m

1

2

High-throughput

0.536

High

1386080

NPS3B
Protein NipSnap homolog 3B

1

2

High-throughput

0.536

High

1386081

LDH6B
L-lactate dehydrogenase A-like 6B

1

2

High-throughput

0.536

High

1386084

MTG2
Mitochondrial ribosome-associated GTPase 2

1

1

High-throughput

0.536

High

1386089

DIC
Mitochondrial dicarboxylate carrier

1

1

High-throughput

0.536

High

1386090

NPS3A
Protein NipSnap homolog 3A

1

2

High-throughput

0.536

High

1386092

AMACR
Alpha-methylacyl-CoA racemase

1

1

High-throughput

0.536

High

1386093

MRM2
rRNA methyltransferase 2, mitochondrial

1

1

High-throughput

0.536

High

1386094

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

2

High-throughput

0.536

High

289800

MTU1
Mitochondrial tRNA-specific 2-thiouridylase 1

1

0

High-throughput

0.513

High

349698

BPNT1
3'(2'),5'-bisphosphate nucleotidase 1

1

0

High-throughput

0.513

High

774549

BASI
Basigin

1

0

High-throughput

0.513

High

1100633

DHRS2
Dehydrogenase/reductase SDR family member 2, mitochondrial

1

0

High-throughput

0.513

High

1158257

RM23
Large ribosomal subunit protein uL23m

1

0

High-throughput

0.513

High

1160432

TAZ
Tafazzin

1

0

High-throughput

0.513

High

1293467

NIT1
Deaminated glutathione amidase

1

0

High-throughput

0.513

High

1341184

PPTC7
Protein phosphatase PTC7 homolog

1

0

High-throughput

0.513

High

260928

RAMP3
Receptor activity-modifying protein 3

1

2

High-throughput

0.489

High

634792

GRAH
Granzyme H

1

6

High-throughput

0.489

High

664072

PRTN3
Myeloblastin

1

6

High-throughput

0.489

High

1206340

WDR44
WD repeat-containing protein 44

1

2

High-throughput

0.489

High

1349086

F174A
Membrane protein FAM174A

1

2

High-throughput

0.489

High

1363198

AQP3
Aquaporin-3

1

2

High-throughput

0.489

High

1384938

TRI43
Tripartite motif-containing protein 43

1

2

High-throughput

0.489

High

1386073

ARHGQ
Rho guanine nucleotide exchange factor 26

1

1

High-throughput

0.489

High

1386077

RSLAB
Ras-like protein family member 10B

1

1

High-throughput

0.489

High

1386086

S6A20
Sodium- and chloride-dependent transporter XTRP3

1

1

High-throughput

0.489

High

1386096

GPR45
Probable G-protein coupled receptor 45

1

2

High-throughput

0.489

High

242533

PRKN
E3 ubiquitin-protein ligase parkin

1

8

High-throughput

0.479

High

984232

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

1

High-throughput

0.470

High

1359172

MAIP1
m-AAA protease-interacting protein 1, mitochondrial

1

0

High-throughput

0.458

High

1386097

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

2

High-throughput

0.445

High

1386087

UBP40
Ubiquitin carboxyl-terminal hydrolase 40

1

5

Small-scale

0.439

High

589367

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.437

High

696167

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.437

High

1254986

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.437

High

1386091

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.437

High

1139238

AR6P1
ADP-ribosylation factor-like protein 6-interacting protein 1

5

0

High-throughput

0.375

High

1247387

ATRAP
Type-1 angiotensin II receptor-associated protein

2

0

High-throughput

0.327

High

226490

SNG3
Synaptogyrin-3

2

0

High-throughput

0.316

High

387596

APOC1
Apolipoprotein C-I

2

0

High-throughput

0.316

High

1187525

AR13B
ADP-ribosylation factor-like protein 13B

2

0

High-throughput

0.316

High

1238180

RHBD2
Rhomboid domain-containing protein 2

2

0

High-throughput

0.316

High

1246206

APOA5
Apolipoprotein A-V

2

0

High-throughput

0.316

High

1307729

CLC10
C-type lectin domain family 10 member A

2

0

High-throughput

0.316

High

1317099

RDH10
Retinol dehydrogenase 10

2

0

High-throughput

0.316

High

1386076

SIG12
Sialic acid-binding Ig-like lectin 12

2

0

High-throughput

0.316

High

366429

FA12
Coagulation factor XII

1

0

High-throughput

0.279

Low

1386072

NUD16
U8 snoRNA-decapping enzyme

1

0

High-throughput

0.279

Low

1386078

GML
Glycosyl-phosphatidylinositol-anchored molecule-like protein

1

0

High-throughput

0.279

Low

1386079

NAA38
N-alpha-acetyltransferase 38, NatC auxiliary subunit

1

0

High-throughput

0.279

Low

1386082

COMD5
COMM domain-containing protein 5

1

0

High-throughput

0.279

Low

595551

H15
Histone H1.5

1

0

High-throughput

0.269

Low

1386095

SHLB1
Endophilin-B1

1

0

High-throughput

0.268

Low

910627

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

0

High-throughput

0.249

Low

1334746

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.249

Low

1386088

NXF1
Nuclear RNA export factor 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025