Protein: ACSF3
Malonate--CoA ligase ACSF3, mitochondrial (EC 6.2.1.76) (Acyl-CoA synthetase family member 3)

Gene: ACSF3
Organism: Homo sapiens
Interactions: 61
UniProt ID: Q4G176

Gene Ontology (top 5):
GO:0005524 - ATP binding
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0006631 - fatty acid metabolic process
GO:0006633 - fatty acid biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1194745

ACSM5
Acyl-coenzyme A synthetase ACSM5, mitochondrial

1

8

High-throughput

0.691

High

532633

CH60
60 kDa heat shock protein, mitochondrial

3

6

High-throughput

0.667

High

1194742

OXLD1
Oxidoreductase-like domain-containing protein 1

3

0

High-throughput

0.638

High

275302

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

2

2

High-throughput

0.628

High

1194762

TMM70
Transmembrane protein 70, mitochondrial

2

1

High-throughput

0.628

High

572005

TRI27
Zinc finger protein RFP

2

2

High-throughput

0.606

High

1194760

KCD14
BTB/POZ domain-containing protein KCTD14

3

1

High-throughput

0.604

High

641789

SDHB
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

2

0

High-throughput

0.602

High

1194763

TR61B
tRNA

2

0

High-throughput

0.602

High

786118

LONM
Lon protease homolog, mitochondrial

2

3

High-throughput

0.601

High

241866

PRKN
E3 ubiquitin-protein ligase parkin

2

8

High-throughput

0.584

High

635323

IMDH1
Inosine-5'-monophosphate dehydrogenase 1

2

3

High-throughput

0.574

High

1194756

ASPP1
Apoptosis-stimulating of p53 protein 1

2

1

High-throughput

0.553

High

258910

DNJA2
DnaJ homolog subfamily A member 2

1

1

High-throughput

0.536

High

690497

KAD4
Adenylate kinase 4, mitochondrial

1

1

High-throughput

0.536

High

842210

THIM
3-ketoacyl-CoA thiolase, mitochondrial

1

2

High-throughput

0.536

High

869169

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

2

High-throughput

0.536

High

1194746

FAHD1
Oxaloacetate tautomerase FAHD1, mitochondrial

1

1

High-throughput

0.536

High

1194754

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

1

1

High-throughput

0.536

High

1194755

RT24
Small ribosomal subunit protein uS3m

1

2

High-throughput

0.536

High

1194768

DIC
Mitochondrial dicarboxylate carrier

1

1

High-throughput

0.536

High

1194769

NPS3A
Protein NipSnap homolog 3A

1

2

High-throughput

0.536

High

1194770

AMACR
Alpha-methylacyl-CoA racemase

1

1

High-throughput

0.536

High

1194771

MRM2
rRNA methyltransferase 2, mitochondrial

1

1

High-throughput

0.536

High

1194774

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

2

High-throughput

0.536

High

1194775

RT02
Small ribosomal subunit protein uS2m

1

1

High-throughput

0.536

High

593389

PGFRA
Platelet-derived growth factor receptor alpha

1

0

High-throughput

0.513

High

1194743

TTBK1
Tau-tubulin kinase 1

1

0

High-throughput

0.513

High

1194750

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1194751

ETKMT
Electron transfer flavoprotein beta subunit lysine methyltransferase

1

0

High-throughput

0.513

High

1194761

MYL10
Myosin regulatory light chain 10

1

0

High-throughput

0.513

High

1194764

GATA
Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

1

0

High-throughput

0.513

High

1194773

RT07
Small ribosomal subunit protein uS7m

1

0

High-throughput

0.513

High

846069

GLP1R
Glucagon-like peptide 1 receptor

1

3

Small-scale

0.504

High

1194766

ABHDA
Palmitoyl-protein thioesterase ABHD10, mitochondrial

1

0

High-throughput

0.493

High

260762

RAMP2
Receptor activity-modifying protein 2

1

2

High-throughput

0.489

High

1194752

F174A
Membrane protein FAM174A

1

2

High-throughput

0.489

High

1194753

TRI43
Tripartite motif-containing protein 43

1

2

High-throughput

0.489

High

1194758

RSLAB
Ras-like protein family member 10B

1

1

High-throughput

0.489

High

1194759

PFD5
Prefoldin subunit 5

1

1

High-throughput

0.489

High

471056

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

1

High-throughput

0.479

High

1162351

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

1

High-throughput

0.479

High

883256

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

0

High-throughput

0.458

High

1048536

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1194777

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

2

High-throughput

0.445

High

588840

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.437

High

695616

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.437

High

768344

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

1194748

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.437

High

653354

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.426

High

1194772

ITM2B
Integral membrane protein 2B

1

0

High-throughput

0.426

High

1194749

ZN467
Zinc finger protein 467

1

1

High-throughput

0.407

High

1194747

T184A
Transmembrane protein 184A

2

0

High-throughput

0.328

High

337508

MATN4
Matrilin-4

2

0

High-throughput

0.316

High

902245

RAB28
Ras-related protein Rab-28

2

0

High-throughput

0.316

High

1194744

K1C40
Keratin, type I cytoskeletal 40

2

0

High-throughput

0.316

High

946416

MTPN
Myotrophin

1

0

High-throughput

0.279

Low

1194767

HAUS2
HAUS augmin-like complex subunit 2

1

0

High-throughput

0.279

Low

1194757

FXL18
F-box/LRR-repeat protein 18

1

0

Small-scale

0.249

Low

1194765

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1194776

AUP1
Lipid droplet-regulating VLDL assembly factor AUP1

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025