HitPredict

Interactor 1: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2

Interactor 2: V9HWD6 (V9HWD6)
14-3-3 protein beta/alpha
Gene: HEL-S-1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	unassigned1853
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2527 Hs			1 246
+	Hs
		909643 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		1433E_HUMAN (3-243): 4.39e-144: 405: 65.43
+	Hs
		683408 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		1433B_HUMAN (1-246): 3.48e-144: 404: 100.00
+	Hs
		927126 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60
+	Hs
		646960 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		1433T_HUMAN (3-244): 3.24e-127: 361: 81.82
+	Hs
		904667 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		1433G_HUMAN (3-246): 1.91e-109: 317: 75.40
+	Hs
		982094 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		1433F_HUMAN (4-244): 2.7e-107: 311: 75.51
+	Hs
		684088 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		1433S_HUMAN (3-239): 3.38e-100: 293: 68.62
+	Mm
		910249 LRRK2_MOUSE (1-2527): 0: 2865: 86.09		1433E_MOUSE (3-243): 4.39e-144: 405: 65.43
+	Mm
		926794 LRRK2_MOUSE (1-2527): 0: 2865: 86.09		1433Z_MOUSE (3-244): 3.14e-142: 399: 88.02
+	Mm
		1130124 LRRK2_MOUSE (1-2527): 0: 2865: 86.09		1433B_MOUSE (1-246): 5.56e-141: 396: 98.78
+	Mm
		933123 LRRK2_MOUSE (1-2527): 0: 2865: 86.09		1433T_MOUSE (3-244): 9.37e-127: 360: 81.82
+	Mm
		905338 LRRK2_MOUSE (1-2527): 0: 2865: 86.09		1433G_MOUSE (3-246): 1.91e-109: 317: 75.40
+	Mm
		935502 LRRK2_MOUSE (1-2527): 0: 2865: 86.09		1433F_MOUSE (4-244): 8.67e-108: 312: 75.51
+	At
		186958 BRI1_ARATH (774-1520): 4.76e-120: 414: 14.52		14332_ARATH (1-241): 4.75e-145: 407: 63.27
+	Hs
		788960 MATK_HUMAN (1683-2160): 3.41e-106: 352: 20.43		1433E_HUMAN (3-243): 4.39e-144: 405: 65.43
+	Hs
		782766 CSK_HUMAN (1722-2140): 2.25e-102: 339: 20.74		1433E_HUMAN (3-243): 4.39e-144: 405: 65.43
+	Hs
		683181 CSK_HUMAN (1722-2140): 2.25e-102: 339: 20.74		1433B_HUMAN (1-246): 3.48e-144: 404: 100.00
+	Hs
		782768 CSK_HUMAN (1722-2140): 2.25e-102: 339: 20.74		1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60
+	Hs
		782764 CSK_HUMAN (1722-2140): 2.25e-102: 339: 20.74		1433G_HUMAN (3-246): 1.91e-109: 317: 75.40
+	Hs
		683883 MATK_HUMAN (1683-2160): 3.41e-106: 352: 20.43		1433S_HUMAN (3-239): 3.38e-100: 293: 68.62