HitPredict

Interactor 1: NHRF3 (Q5T2W1)
Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (NHERF-3) (CFTR-associated protein of 70 kDa) (Na(+)/H(+) exchanger regulatory factor 3) (Na/Pi cotransporter C-terminal-associated protein 1) (NaPi-Cap1) (PDZ domain-containing protein 1) (Sodium-hydrogen exchanger regulatory factor 3)
Gene: PDZK1

Interactor 2: RHG17 (Q68EM7)
Rho GTPase-activating protein 17 (Rho-type GTPase-activating protein 17) (RhoGAP interacting with CIP4 homologs protein 1) (RICH-1)
Gene: ARHGAP17

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 519 Hs			1 881
+	Hs
		1148381 DLG3_HUMAN (3-359): 3.36e-32: 133: 17.27		RHG17_HUMAN (1-881): 4.48e-144: 450: 100.00
+	Hs
		153929 NHRF1_HUMAN (5-134): 6.99e-24: 104: 31.54		RHG17_HUMAN (1-881): 4.48e-144: 450: 100.00
+	Hs
		1075417 NHRF2_HUMAN (5-146): 7.72e-20: 92.8: 28.17		RHG17_HUMAN (1-881): 4.48e-144: 450: 100.00
+	Hs
		67911 PDZ1P_HUMAN (6-134): 6.25e-18: 87.9: 28.68		RHG17_HUMAN (1-881): 4.48e-144: 450: 100.00
+	Hs
		1075409 NHRF2_HUMAN (5-146): 7.72e-20: 92.8: 28.17		RHG44_HUMAN (1-754): 4.1e-106: 348: 46.20
+	Hs
		506603 NHRF3_HUMAN (1-519): 1.87e-114: 350: 100.00		BCR_HUMAN (250-408): 2.36e-16: 86.3: 33.54
+	Hs
		253346 PTN13_HUMAN (72-497): 1.88e-29: 125: 12.84		SRGP2_HUMAN (13-819): 1.69e-82: 289: 14.90
+	Hs
		1020174 PTN13_HUMAN (72-497): 1.88e-29: 125: 12.84		RHG29_HUMAN (8-786): 6.57e-78: 278: 13.09
+	Mm
		1131438 DLG4_MOUSE (3-344): 3.77e-36: 144: 16.96		ABR_MOUSE (1-412): 1.2e-70: 252: 18.94
+	Mm
		1265174 LNX2_MOUSE (174-495): 2.29e-20: 96.8: 13.25		SRGP2_MOUSE (13-819): 5.39e-85: 296: 14.65
+	Mm
		250652 LNX1_MOUSE (2-213): 1.09e-19: 94.8: 15.70		SRGP2_MOUSE (13-819): 5.39e-85: 296: 14.65
+	Hs
		253399 MAGI1_HUMAN (183-460): 1.21e-20: 98.3: 19.89		SRGP2_HUMAN (13-819): 1.69e-82: 289: 14.90
+	Mm
		250653 LNX1_MOUSE (2-213): 1.09e-19: 94.8: 15.70		SRGP1_MOUSE (13-823): 4.01e-78: 276: 14.51
+	Hs
		1021847 LNX1_HUMAN (4-213): 1.57e-20: 97.1: 16.74		ABR_HUMAN (1-412): 3.62e-71: 253: 19.17
+	Hs
		856141 NHRF2_HUMAN (5-146): 7.72e-20: 92.8: 28.17		CHIO_HUMAN (231-442): 5.78e-65: 227: 25.12
+	Mm
		1143388 DLG4_MOUSE (3-344): 3.77e-36: 144: 16.96		RHG32_MOUSE (250-462): 2.1e-17: 89.7: 29.41
+	Hs
		506645 MAGI1_HUMAN (183-460): 1.21e-20: 98.3: 19.89		BCR_HUMAN (250-408): 2.36e-16: 86.3: 33.54
+	Hs
		506626 LNX1_HUMAN (4-213): 1.57e-20: 97.1: 16.74		BCR_HUMAN (250-408): 2.36e-16: 86.3: 33.54
+	Mm
		250626 LNX1_MOUSE (2-213): 1.09e-19: 94.8: 15.70		BCR_MOUSE (250-408): 6.8e-17: 88.2: 33.54
+	Hs
		67905 PDZ1P_HUMAN (6-134): 6.25e-18: 87.9: 28.68		BCR_HUMAN (250-408): 2.36e-16: 86.3: 33.54