HitPredict

Interactor 1: DDI2 (Q5TDH0)
Protein DDI1 homolog 2 (EC 3.4.23.-)
Gene: DDI2

Interactor 2: DDI1 (Q8WTU0)
Protein DDI1 homolog 1 (EC 3.4.23.-)
Gene: DDI1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Asp_protease~Asp_protease, ubiquitin~ubiquitin
Common GO terms	GO:0004190 - aspartic-type endopeptidase activity GO:0010498 - proteasomal protein catabolic process GO:0031647 - regulation of protein stability GO:0072711 - cellular response to hydroxyurea GO:0097752 - regulation of DNA stability
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 399 Hs			1 396
+	Hs
		1136623 DDI2_HUMAN (1-399): 1.67e-162: 463: 100.00		DDI2_HUMAN (1-392): 2.76e-155: 445: 70.93
+	Hs
		1259544 DDI1_HUMAN (1-392): 7.44e-148: 426: 70.75		DDI1_HUMAN (1-396): 4.1e-163: 465: 100.00
+	Dm
		1375389 Q9VXF9_DROME (5-395): 2.61e-124: 368: 46.38		Q9VXF9_DROME (5-395): 3.91e-131: 386: 47.58
+	Hs
		1136657 DDI2_HUMAN (1-399): 1.67e-162: 463: 100.00		UBQL2_HUMAN (5-249): 4.55e-46: 168: 14.74
+	Hs
		1136655 DDI2_HUMAN (1-399): 1.67e-162: 463: 100.00		NRIP3_HUMAN (243-382): 9.23e-43: 151: 24.65
+	Hs
		1259556 DDI1_HUMAN (1-392): 7.44e-148: 426: 70.75		NRIP3_HUMAN (243-382): 9.23e-43: 151: 24.65
+	Sc
		768183 DDI1_YEAST (3-395): 7.99e-93: 287: 30.92		DDI1_YEAST (14-369): 1.01e-91: 284: 29.41
+	Hs
		803572 DDI2_HUMAN (1-399): 1.67e-162: 463: 100.00		BAG6_HUMAN (4-168): 1.28e-24: 108: 15.25
+	Zm
		80385 K7UR93_MAIZE (5-384): 2.9e-111: 333: 35.25		B6TNT9_MAIZE (4-249): 2.98e-49: 176: 17.46
+	Dm
		1362834 Q9VXF9_DROME (5-395): 2.61e-124: 368: 46.38		Q9VCD5_DROME (5-218): 1.23e-30: 120: 18.92
+	Hs
		1357342 UBQL1_HUMAN (5-241): 5.78e-49: 176: 14.80		UBQL1_HUMAN (5-249): 3.83e-47: 171: 14.74
+	Hs
		1355403 UBQL1_HUMAN (5-241): 5.78e-49: 176: 14.80		UBQL2_HUMAN (5-249): 4.55e-46: 168: 14.74
+	Hs
		1345051 UBQL1_HUMAN (5-241): 5.78e-49: 176: 14.80		UBQL4_HUMAN (8-249): 3.58e-43: 160: 14.24
+	Mm
		1246842 UBQL1_MOUSE (5-241): 1.94e-49: 177: 14.80		UBQL2_MOUSE (5-249): 6.77e-41: 155: 14.18
+	Hs
		803807 UBQL1_HUMAN (5-241): 5.78e-49: 176: 14.80		BAG6_HUMAN (4-168): 1.28e-24: 108: 15.25
+	Hs
		803794 UBQL2_HUMAN (5-241): 1.08e-47: 173: 15.20		BAG6_HUMAN (4-168): 1.28e-24: 108: 15.25
+	Hs
		924216 UBQL1_HUMAN (5-241): 5.78e-49: 176: 14.80		RS27A_HUMAN (5-93): 5.56e-24: 98.8: 17.98
+	Hs
		924208 UBQL2_HUMAN (5-241): 1.08e-47: 173: 15.20		RS27A_HUMAN (5-93): 5.56e-24: 98.8: 17.98