HitPredict

Interactor 1: DDI2 (Q5TDH0)
Protein DDI1 homolog 2 (EC 3.4.23.-)
Gene: DDI2

Interactor 2: RN166 (Q96A37)
E3 ubiquitin-protein ligase RNF166 (EC 2.3.2.27) (RING finger protein 166) (RING-type E3 ubiquitin transferase RNF166)
Gene: RNF166

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.80	0.618

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	ubiquitin~zf-RING_UBOX
Common GO terms	-
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 399 Hs			1 237
+	Hs
		1020830 DDI1_HUMAN (1-392): 7.44e-148: 426: 70.75		TRAF2_HUMAN (15-186): 9.47e-27: 109: 20.65
+	Hs
		1345055 UBQL4_HUMAN (8-241): 1.8e-44: 164: 14.59		RN114_HUMAN (18-236): 1.44e-49: 163: 46.12
+	Hs
		1019380 UBQL2_HUMAN (5-241): 1.08e-47: 173: 15.20		TRI26_HUMAN (19-174): 1.05e-34: 131: 18.24
+	Hs
		1313380 UBQL2_HUMAN (5-241): 1.08e-47: 173: 15.20		TRAF4_HUMAN (17-212): 3.54e-28: 112: 18.50
+	Hs
		1318731 UBQL2_HUMAN (5-241): 1.08e-47: 173: 15.20		TRIM4_HUMAN (22-162): 4.4e-28: 112: 19.58
+	Hs
		1020971 UBQL2_HUMAN (5-241): 1.08e-47: 173: 15.20		TRAF2_HUMAN (15-186): 9.47e-27: 109: 20.65
+	Hs
		1318716 UBQL2_HUMAN (5-241): 1.08e-47: 173: 15.20		TRIM5_HUMAN (21-166): 6.19e-25: 103: 20.53
+	Hs
		1020952 UBQL4_HUMAN (8-241): 1.8e-44: 164: 14.59		TRAF2_HUMAN (15-186): 9.47e-27: 109: 20.65
+	Hs
		584896 BAG6_HUMAN (4-173): 4.8e-28: 118: 15.08		RO52_HUMAN (19-166): 8.73e-31: 120: 20.95
+	Hs
		872150 RD23A_HUMAN (3-198): 2.36e-28: 116: 15.00		TRAF3_HUMAN (15-215): 4.28e-31: 121: 20.29
+	Hs
		129543 RD23A_HUMAN (3-198): 2.36e-28: 116: 15.00		TRAF5_HUMAN (12-237): 8.71e-31: 120: 21.21
+	Mm
		936293 BAG6_MOUSE (4-181): 9.27e-28: 117: 14.14		TRAF6_MOUSE (8-235): 1.28e-29: 117: 16.52
+	Hs
		872235 RD23A_HUMAN (3-198): 2.36e-28: 116: 15.00		TRAF6_HUMAN (8-235): 8.66e-29: 114: 17.83
+	Hs
		872149 RD23A_HUMAN (3-198): 2.36e-28: 116: 15.00		TRAF2_HUMAN (15-186): 9.47e-27: 109: 20.65
+	Hs
		872214 RD23A_HUMAN (3-198): 2.36e-28: 116: 15.00		RNF41_HUMAN (25-145): 9.57e-28: 109: 21.43
+	Mm
		924236 RS27A_MOUSE (10-77): 3.2e-14: 71.7: 22.06		RO52_MOUSE (15-165): 5.11e-31: 120: 18.54
+	Hs
		924227 RS27A_HUMAN (10-77): 3.2e-14: 71.7: 22.06		TRAF6_HUMAN (8-235): 8.66e-29: 114: 17.83
+	Hs
		924151 RS27A_HUMAN (10-77): 3.2e-14: 71.7: 22.06		TRI31_HUMAN (19-180): 1.72e-25: 104: 15.85