Protein: HERP1
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (Methyl methanesulfonate (MMF)-inducible fragment protein 1)

Gene: HERP1, HERPUD1
Organism: Homo sapiens
Interactions: 164
UniProt ID: Q15011

Gene Ontology (top 5):
GO:0000836 - Hrd1p ubiquitin ligase complex
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0006986 - response to unfolded protein

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1136701

AMFR
E3 ubiquitin-protein ligase AMFR

8

2

Small-scale

0.968

High

1136657

SYVN1
E3 ubiquitin-protein ligase synoviolin

8

2

Small-scale

0.966

High

1136698

UBQL2
Ubiquilin-2

3

4

Small-scale

0.827

High

934627

TERA
Transitional endoplasmic reticulum ATPase

2

1

Small-scale

0.806

High

294783

CAN15
Calpain-15

3

0

High-throughput

0.709

High

1136685

TOLIP
Toll-interacting protein

1

0

High-throughput

0.663

High

1136666

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

2

0

High-throughput

0.648

High

1136656

SH3R1
E3 ubiquitin-protein ligase SH3RF1

1

0

Small-scale

0.633

High

507995

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

1

Small-scale

0.618

High

610332

PRS6A
26S proteasome regulatory subunit 6A

1

2

High-throughput

0.618

High

856697

BAG6
Large proline-rich protein BAG6

1

4

High-throughput

0.618

High

1136689

UBQL4
Ubiquilin-4

1

4

Small-scale

0.618

High

1136703

UBQL1
Ubiquilin-1

1

4

Small-scale

0.618

High

1136655

ATG9A
Autophagy-related protein 9A

2

0

High-throughput

0.602

High

138115

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

0

High-throughput

0.586

High

443368

CDK1
Cyclin-dependent kinase 1

1

0

High-throughput

0.586

High

987031

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

0

High-throughput

0.586

High

1097985

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

0

Small-scale

0.586

High

1136637

ELOC
Elongin-C

1

0

High-throughput

0.586

High

1136676

CGRF1
Cell growth regulator with RING finger domain protein 1

1

0

High-throughput

0.586

High

1136707

AUP1
Lipid droplet-regulating VLDL assembly factor AUP1

1

0

High-throughput

0.586

High

1032971

EWS
RNA-binding protein EWS

1

0

High-throughput

0.584

High

889985

PSN1
Presenilin-1

2

0

Small-scale

0.559

High

1136660

KATL2
Katanin p60 ATPase-containing subunit A-like 2

1

2

High-throughput

0.553

High

466848

ACM2
Muscarinic acetylcholine receptor M2

1

0

High-throughput

0.518

High

619312

LFA3
Lymphocyte function-associated antigen 3

1

0

High-throughput

0.518

High

835484

CCR2
C-C chemokine receptor type 2

1

0

High-throughput

0.518

High

936951

CASP9
Caspase-9

1

0

High-throughput

0.517

High

1004581

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.517

High

1136662

IASPP
RelA-associated inhibitor

1

0

High-throughput

0.517

High

1136673

TRI47
E3 ubiquitin-protein ligase TRIM47

1

0

High-throughput

0.517

High

1136677

TS101
Tumor susceptibility gene 101 protein

1

0

High-throughput

0.517

High

1136697

TBK1
Serine/threonine-protein kinase TBK1

1

0

Small-scale

0.517

High

1136664

SFT2A
Vesicle transport protein SFT2A

1

0

High-throughput

0.513

High

1136667

SPSB4
SPRY domain-containing SOCS box protein 4

1

0

High-throughput

0.513

High

1136695

SE1L1
Protein sel-1 homolog 1

1

0

Small-scale

0.513

High

936047

PAR2
Proteinase-activated receptor 2

1

1

High-throughput

0.494

High

1136692

C5AR2
C5a anaphylatoxin chemotactic receptor 2

1

1

High-throughput

0.494

High

558145

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.486

High

912567

GDIR1
Rho GDP-dissociation inhibitor 1

1

0

High-throughput

0.486

High

422120

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

1136694

FA8A1
Protein FAM8A1

1

0

Small-scale

0.479

High

249466

ACSL4
Long-chain-fatty-acid--CoA ligase 4

1

1

High-throughput

0.479

High

339496

ACSL3
Fatty acid CoA ligase Acsl3

1

1

High-throughput

0.479

High

552241

ADT3
ADP/ATP translocase 3

1

1

High-throughput

0.479

High

1024359

S25A3
Solute carrier family 25 member 3

1

2

High-throughput

0.479

High

1136635

PCBP1
Poly(rC)-binding protein 1

1

1

High-throughput

0.479

High

1136636

PCBP2
Poly(rC)-binding protein 2

1

1

High-throughput

0.479

High

1136639

TRAM1
Translocating chain-associated membrane protein 1

1

1

High-throughput

0.479

High

1136670

CERS2
Ceramide synthase 2

1

1

High-throughput

0.479

High

1136682

DERL1
Derlin-1

1

2

Small-scale

0.479

High

1136684

DERL2
Derlin-2

1

2

Small-scale

0.479

High

124352

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.458

High

158205

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.458

High

210949

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

0

High-throughput

0.458

High

283250

ERLN1
Erlin-1

1

0

High-throughput

0.458

High

291342

NU155
Nuclear pore complex protein Nup155

1

0

High-throughput

0.458

High

415579

HSPB1
Heat shock protein beta-1

1

0

High-throughput

0.458

High

417445

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.458

High

418138

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.458

High

469081

SRPRA
Signal recognition particle receptor subunit alpha

1

0

High-throughput

0.458

High

471651

CY1
Cytochrome c1, heme protein, mitochondrial

1

0

High-throughput

0.458

High

575752

IL1R1
Interleukin-1 receptor type 1

1

0

Small-scale

0.458

High

646846

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

High-throughput

0.458

High

693750

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.458

High

697538

PYR1
Multifunctional protein CAD

1

0

High-throughput

0.458

High

756201

MCM7
DNA replication licensing factor MCM7

1

0

High-throughput

0.458

High

791389

SYUA
Alpha-synuclein

1

0

Small-scale

0.458

High

800490

VATA
V-type proton ATPase catalytic subunit A

1

0

High-throughput

0.458

High

814527

FEN1
Flap endonuclease 1

1

0

High-throughput

0.458

High

837622

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.458

High

843570

HD
Huntingtin

1

0

Small-scale

0.458

High

880552

LMAN1
Protein ERGIC-53

1

0

High-throughput

0.458

High

894759

EMD
Emerin

1

0

High-throughput

0.458

High

895239

CPT1A
Carnitine O-palmitoyltransferase 1, liver isoform

1

0

High-throughput

0.458

High

910519

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

0

High-throughput

0.458

High

912887

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

0

High-throughput

0.458

High

938217

SEC13
Protein SEC13 homolog

1

0

High-throughput

0.458

High

1005674

IF4G2
Eukaryotic translation initiation factor 4 gamma 2

1

0

High-throughput

0.458

High

1096005

TADBP
TAR DNA-binding protein 43

1

0

High-throughput

0.458

High

1106402

TNK1
Non-receptor tyrosine-protein kinase TNK1

1

0

High-throughput

0.458

High

1107729

SQSTM
Sequestosome-1

1

0

High-throughput

0.458

High

1125439

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

0

High-throughput

0.458

High

1126228

PDE3A
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A

1

0

High-throughput

0.458

High

1131723

LBR
Delta(14)-sterol reductase LBR

1

0

High-throughput

0.458

High

1136010

CND2
Condensin complex subunit 2

1

0

High-throughput

0.458

High

1136114

SPCS2
Signal peptidase complex subunit 2

1

0

High-throughput

0.458

High

1136638

DHC24
Delta(24)-sterol reductase

1

0

High-throughput

0.458

High

1136640

AAAT
Neutral amino acid transporter B(0)

1

0

High-throughput

0.458

High

1136641

MLF2
Myeloid leukemia factor 2

1

0

High-throughput

0.458

High

1136644

CP51A
Lanosterol 14-alpha demethylase

1

0

High-throughput

0.458

High

1136649

BRAT1
Integrator complex assembly factor BRAT1

1

0

High-throughput

0.458

High

1136650

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

1136651

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1136652

LARP4
La-related protein 4

1

0

High-throughput

0.458

High

1136653

SND1
Staphylococcal nuclease domain-containing protein 1

1

0

High-throughput

0.458

High

1136658

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

0

Small-scale

0.458

High

1136659

MIRO2
Mitochondrial Rho GTPase 2

1

0

High-throughput

0.458

High

1136661

SCPDL
Saccharopine dehydrogenase-like oxidoreductase

1

0

High-throughput

0.458

High

1136663

NU133
Nuclear pore complex protein Nup133

1

0

High-throughput

0.458

High

1136665

HS105
Heat shock protein 105 kDa

1

0

High-throughput

0.458

High

1136668

FAF2
FAS-associated factor 2

1

0

High-throughput

0.458

High

1136672

S35E1
Solute carrier family 35 member E1

1

0

High-throughput

0.458

High

1136679

SELS
Selenoprotein S

1

0

Small-scale

0.458

High

1136680

TMM43
Transmembrane protein 43

1

0

High-throughput

0.458

High

1136683

UBXN6
UBX domain-containing protein 6

1

0

Small-scale

0.458

High

1136688

RTN4
Reticulon-4

1

0

High-throughput

0.458

High

1136690

ELOV5
Very long chain fatty acid elongase 5

1

0

High-throughput

0.458

High

1136691

HACD3
Very-long-chain

1

0

High-throughput

0.458

High

1136696

ABCF2
ATP-binding cassette sub-family F member 2

1

0

High-throughput

0.458

High

1136700

PARP4
Protein mono-ADP-ribosyltransferase PARP4

1

0

High-throughput

0.458

High

1136702

TMCO1
Calcium load-activated calcium channel

1

0

High-throughput

0.458

High

1136704

SSRG
Translocon-associated protein subunit gamma

1

0

High-throughput

0.458

High

1136705

SYFA
Phenylalanine--tRNA ligase alpha subunit

1

0

High-throughput

0.458

High

1136706

GOT1B
Vesicle transport protein GOT1B

1

0

High-throughput

0.458

High

539058

UMPS
Uridine 5'-monophosphate synthase

1

1

High-throughput

0.437

High

786613

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

1

High-throughput

0.437

High

827788

STAT3
Signal transducer and activator of transcription 3

1

1

High-throughput

0.437

High

838099

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

1

High-throughput

0.437

High

916261

TXTP
Tricarboxylate transport protein, mitochondrial

1

2

High-throughput

0.437

High

968305

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

1

High-throughput

0.437

High

1094176

ACACA
Acetyl-CoA carboxylase 1

1

1

High-throughput

0.437

High

1122060

UBP2L
Ubiquitin-associated protein 2-like

1

1

High-throughput

0.437

High

1136699

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

1

High-throughput

0.437

High

588726

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.282

High

1136693

STAR9
StAR-related lipid transfer protein 9

1

0

High-throughput

0.282

High

71028

BBIP1
BBSome-interacting protein 1

1

0

High-throughput

0.249

Low

76115

B4DET5
cDNA FLJ59484, highly similar to Nuclear envelope pore membrane protein POM 121

1

0

High-throughput

0.249

Low

165580

SCAM3
Secretory carrier-associated membrane protein 3

1

0

High-throughput

0.249

Low

209565

SERA
D-3-phosphoglycerate dehydrogenase

1

0

High-throughput

0.249

Low

211319

RFOX2
RNA binding protein fox-1 homolog 2

1

0

High-throughput

0.249

Low

254139

CTND1
Catenin delta-1

1

0

High-throughput

0.249

Low

367181

ATP6
ATP synthase F(0) complex subunit a

1

0

High-throughput

0.249

Low

369050

ASSY
Argininosuccinate synthase

1

0

High-throughput

0.249

Low

459890

APT
Adenine phosphoribosyltransferase

1

0

High-throughput

0.249

Low

651806

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

1

0

High-throughput

0.249

Low

687678

SYTC
Threonine--tRNA ligase 1, cytoplasmic

1

0

High-throughput

0.249

Low

690704

AOFB
Amine oxidase [flavin-containing] B

1

0

High-throughput

0.249

Low

700641

PSA5
Proteasome subunit alpha type-5

1

0

High-throughput

0.249

Low

854654

RAGP1
Ran GTPase-activating protein 1

1

0

High-throughput

0.249

Low

931363

AT1B3
Sodium/potassium-transporting ATPase subunit beta-3

1

0

High-throughput

0.249

Low

1052953

FOLC
Folylpolyglutamate synthase, mitochondrial

1

0

High-throughput

0.249

Low

1063257

GOGA2
Golgin subfamily A member 2

1

0

High-throughput

0.249

Low

1121027

BOP1
Ribosome biogenesis protein BOP1

1

0

High-throughput

0.249

Low

1124451

MAP7
Ensconsin

1

0

High-throughput

0.249

Low

1129405

PUM1
Pumilio homolog 1

1

0

High-throughput

0.249

Low

1136642

PSMD5
26S proteasome non-ATPase regulatory subunit 5

1

0

High-throughput

0.249

Low

1136643

SMN
Survival motor neuron protein

1

0

High-throughput

0.249

Low

1136645

TRXR1
Thioredoxin reductase 1, cytoplasmic

1

0

High-throughput

0.249

Low

1136646

TOIP1
Torsin-1A-interacting protein 1

1

0

High-throughput

0.249

Low

1136647

TM201
Transmembrane protein 201

1

0

High-throughput

0.249

Low

1136648

CDC73
Parafibromin

1

0

High-throughput

0.249

Low

1136654

EIF3M
Eukaryotic translation initiation factor 3 subunit M

1

0

High-throughput

0.249

Low

1136669

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

0

High-throughput

0.249

Low

1136671

LTV1
Protein LTV1 homolog

1

0

High-throughput

0.249

Low

1136674

QKI
KH domain-containing RNA-binding protein QKI

1

0

High-throughput

0.249

Low

1136675

PHB2
Prohibitin-2

1

0

High-throughput

0.249

Low

1136678

DUS9
Dual specificity protein phosphatase 9

1

0

High-throughput

0.249

Low

1136681

TBB6
Tubulin beta-6 chain

1

0

High-throughput

0.249

Low

1136686

SFXN1
Sideroflexin-1

1

0

High-throughput

0.249

Low

1136687

IL23A
Interleukin-23 subunit alpha

1

0

Small-scale

0.249

Low

1136708

CFA20
Cilia- and flagella-associated protein 20

1

0

High-throughput

0.249

Low

1136709

SNCAP
Synphilin-1

1

0

Small-scale

0.249

Low

161873

IMPA2
Inositol monophosphatase 2

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025